Inhibition of nitric oxide synthesis increases apoptotic cardiomyocyte death and myocardial angiotensin-converting enzyme gene expression in ischemia/reperfusion-injured myocardium of rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-12

AUTHORS

T.-J. Youn, C.-H. Kim, H.-J. Kang, D.-W. Kim, M.-C. Cho, C.-H. Kim, B.-H. Oh, M.-M. Lee, Y.-B. Park

ABSTRACT

Cardiomyocyte apoptosis is an important pathogenic mechanism in myocardial ischemia/reperfusion (I/R) injury. It has been shown that nitric oxide (NO) and the renin–angiotensin system (RAS) are closely related, and both systems regulate apoptotic cell death. However, the effects of NO modulation on myocardial apoptotic cell death and changes in the RAS in the I/R-injured myocardium have not been studied. Female Sprague–Dawley rats were randomized into three groups: NO synthesis inhibitor, NG-nitro-l-arginine-methyl ester (l-NAME, 10 mg/kg); NO precursor, l-arginine (540 mg/kg); and vehicle. The rats were then subjected to 45 min coronary occlusion followed by 4 h reperfusion. The TdT-mediated in situ nick and labeling (TUNEL) indices were 39.9% ± 0.8% at the border and 30.9% ± 1.2% at the center of the I/R area in the vehicle group. L-NAME administration significantly increased these TUNEL-positive cells to 45.3% ± 1.9% and 37.9% ± 1.3%, respectively (P < 0.05 each). L-arginine administration reduced the TUNEL index at the border zone with marginal significance (P = 0.08 vs vehicle group). I/R injury significantly reduced the angiotensin-converting enzyme (ACE) mRNA expression in the left (ventricular) free wall of vehicle group rats. However, ACE mRNA expression was 1.9 times greater in the L-NAME group than that in the vehicle group (P < 0.05). This study showed that the inhibition of NO synthesis increased apoptotic cardiomyocyte death and local ACE mRNA expression in the I/R-injured myocardium. Our observations indicate that NO, ACE, and apoptotic cardiomyocyte death are related to each other during I/R injury. More... »

PAGES

12-19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/pl00007274

DOI

http://dx.doi.org/10.1007/pl00007274

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046583081

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11829213


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Nick-End Labeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitric Oxide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptidyl-Dipeptidase A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Random Allocation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reperfusion Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Statistics, Nonparametric", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea, KR", 
          "id": "http://www.grid.ac/institutes/grid.254229.a", 
          "name": [
            "Department of Internal Medicine and Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Youn", 
        "givenName": "T.-J.", 
        "id": "sg:person.0634045514.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634045514.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "C.-H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "H.-J.", 
        "id": "sg:person.014376272237.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014376272237.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea, KR", 
          "id": "http://www.grid.ac/institutes/grid.254229.a", 
          "name": [
            "Department of Internal Medicine and Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "D.-W.", 
        "id": "sg:person.016513670520.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016513670520.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea, KR", 
          "id": "http://www.grid.ac/institutes/grid.254229.a", 
          "name": [
            "Department of Internal Medicine and Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "M.-C.", 
        "id": "sg:person.01224452677.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224452677.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "C.-H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "B.-H.", 
        "id": "sg:person.01132635714.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132635714.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "M.-M.", 
        "id": "sg:person.01173564076.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173564076.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Y.-B.", 
        "id": "sg:person.0661601052.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661601052.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s003950050149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015917721", 
          "https://doi.org/10.1007/s003950050149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003950050068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029776488", 
          "https://doi.org/10.1007/s003950050068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02750637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000234020", 
          "https://doi.org/10.1007/bf02750637"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-12", 
    "datePublishedReg": "2001-12-01", 
    "description": "Abstract Cardiomyocyte apoptosis is an important pathogenic mechanism in myocardial ischemia/reperfusion (I/R) injury. It has been shown that nitric oxide (NO) and the renin\u2013angiotensin system (RAS) are closely related, and both systems regulate apoptotic cell death. However, the effects of NO modulation on myocardial apoptotic cell death and changes in the RAS in the I/R-injured myocardium have not been studied. Female Sprague\u2013Dawley rats were randomized into three groups: NO synthesis inhibitor, NG-nitro-l-arginine-methyl ester (l-NAME, 10 mg/kg); NO precursor, l-arginine (540 mg/kg); and vehicle. The rats were then subjected to 45 min coronary occlusion followed by 4 h reperfusion. The TdT-mediated in situ nick and labeling (TUNEL) indices were 39.9% \u00b1 0.8% at the border and 30.9% \u00b1 1.2% at the center of the I/R area in the vehicle group. L-NAME administration significantly increased these TUNEL-positive cells to 45.3% \u00b1 1.9% and 37.9% \u00b1 1.3%, respectively (P < 0.05 each). L-arginine administration reduced the TUNEL index at the border zone with marginal significance (P = 0.08 vs vehicle group). I/R injury significantly reduced the angiotensin-converting enzyme (ACE) mRNA expression in the left (ventricular) free wall of vehicle group rats. However, ACE mRNA expression was 1.9 times greater in the L-NAME group than that in the vehicle group (P < 0.05). This study showed that the inhibition of NO synthesis increased apoptotic cardiomyocyte death and local ACE mRNA expression in the I/R-injured myocardium. Our observations indicate that NO, ACE, and apoptotic cardiomyocyte death are related to each other during I/R injury.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/pl00007274", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1095887", 
        "issn": [
          "0910-8327", 
          "1615-2573"
        ], 
        "name": "Heart and Vessels", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "keywords": [
      "renin-angiotensin system", 
      "apoptotic cardiomyocyte death", 
      "ACE mRNA expression", 
      "vehicle group", 
      "cardiomyocyte death", 
      "R injury", 
      "mRNA expression", 
      "myocardial ischemia/reperfusion injury", 
      "ischemia/reperfusion injury", 
      "nitric oxide", 
      "female Sprague-Dawley rats", 
      "L-arginine administration", 
      "L-NAME administration", 
      "L-NAME group", 
      "min coronary occlusion", 
      "apoptotic cell death", 
      "Sprague-Dawley rats", 
      "arginine methyl ester", 
      "left free wall", 
      "nitric oxide synthesis", 
      "important pathogenic mechanism", 
      "TUNEL-positive cells", 
      "enzyme mRNA expression", 
      "cell death", 
      "myocardial angiotensin", 
      "reperfusion injury", 
      "NG-nitro", 
      "h reperfusion", 
      "coronary occlusion", 
      "free wall", 
      "pathogenic mechanisms", 
      "labeling index", 
      "cardiomyocyte apoptosis", 
      "oxide synthesis", 
      "myocardial apoptotic cell death", 
      "enzyme gene expression", 
      "injury", 
      "rats", 
      "myocardium", 
      "death", 
      "marginal significance", 
      "TUNEL index", 
      "angiotensin", 
      "synthesis inhibitor", 
      "situ nick", 
      "border zone", 
      "administration", 
      "group", 
      "inhibition", 
      "expression", 
      "R area", 
      "gene expression", 
      "reperfusion", 
      "occlusion", 
      "index", 
      "apoptosis", 
      "inhibitors", 
      "ACE", 
      "cells", 
      "arginine", 
      "modulation", 
      "significance", 
      "center", 
      "study", 
      "nick", 
      "effect", 
      "changes", 
      "mechanism", 
      "wall", 
      "border", 
      "time", 
      "esters", 
      "area", 
      "synthesis", 
      "observations", 
      "system", 
      "precursors", 
      "oxide", 
      "vehicles", 
      "zone"
    ], 
    "name": "Inhibition of nitric oxide synthesis increases apoptotic cardiomyocyte death and myocardial angiotensin-converting enzyme gene expression in ischemia/reperfusion-injured myocardium of rats", 
    "pagination": "12-19", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046583081"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/pl00007274"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11829213"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/pl00007274", 
      "https://app.dimensions.ai/details/publication/pub.1046583081"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_333.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/pl00007274"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/pl00007274'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/pl00007274'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/pl00007274'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/pl00007274'


 

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      21 PREDICATES      122 URIs      111 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/pl00007274 schema:about N10511ceca50c4f85beb9935839f593f1
2 N17f186bfe8fe4ee6b6b35600dae4e40f
3 N2cefa1b7956749dd8826597ba6610de4
4 N3748981ad7d740dbbf2f67180b342a9e
5 N380ba5cb3b2f45e6aaa744e1989943fa
6 N3af43a21d11d413b9bf3b95e1eb797d2
7 N5dac01144704497c99ff5de8c52fe64b
8 N790e841a00a344a7875167bb811d0354
9 N8ce4c8722958405fb79991920457866f
10 Nb4d9688608e84f9980a44527eaeb62cd
11 Nebe45cdd04d14532b5d98555c795788e
12 Neef61ddabc584686b31b483566e0b572
13 Nf37f8ab6849d45d78e5738e7c9a6a8e8
14 anzsrc-for:11
15 anzsrc-for:1116
16 schema:author N007972e8bb7e4f5ba7d477d52c8d6658
17 schema:citation sg:pub.10.1007/bf02750637
18 sg:pub.10.1007/s003950050068
19 sg:pub.10.1007/s003950050149
20 schema:datePublished 2001-12
21 schema:datePublishedReg 2001-12-01
22 schema:description Abstract Cardiomyocyte apoptosis is an important pathogenic mechanism in myocardial ischemia/reperfusion (I/R) injury. It has been shown that nitric oxide (NO) and the renin–angiotensin system (RAS) are closely related, and both systems regulate apoptotic cell death. However, the effects of NO modulation on myocardial apoptotic cell death and changes in the RAS in the I/R-injured myocardium have not been studied. Female Sprague–Dawley rats were randomized into three groups: NO synthesis inhibitor, NG-nitro-l-arginine-methyl ester (l-NAME, 10 mg/kg); NO precursor, l-arginine (540 mg/kg); and vehicle. The rats were then subjected to 45 min coronary occlusion followed by 4 h reperfusion. The TdT-mediated in situ nick and labeling (TUNEL) indices were 39.9% ± 0.8% at the border and 30.9% ± 1.2% at the center of the I/R area in the vehicle group. L-NAME administration significantly increased these TUNEL-positive cells to 45.3% ± 1.9% and 37.9% ± 1.3%, respectively (P < 0.05 each). L-arginine administration reduced the TUNEL index at the border zone with marginal significance (P = 0.08 vs vehicle group). I/R injury significantly reduced the angiotensin-converting enzyme (ACE) mRNA expression in the left (ventricular) free wall of vehicle group rats. However, ACE mRNA expression was 1.9 times greater in the L-NAME group than that in the vehicle group (P < 0.05). This study showed that the inhibition of NO synthesis increased apoptotic cardiomyocyte death and local ACE mRNA expression in the I/R-injured myocardium. Our observations indicate that NO, ACE, and apoptotic cardiomyocyte death are related to each other during I/R injury.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf Nde0b096fcdf6457780b924db3f39f657
26 Nfb86659ed70c4208aacf1ec3a234f989
27 sg:journal.1095887
28 schema:keywords ACE
29 ACE mRNA expression
30 L-NAME administration
31 L-NAME group
32 L-arginine administration
33 NG-nitro
34 R area
35 R injury
36 Sprague-Dawley rats
37 TUNEL index
38 TUNEL-positive cells
39 administration
40 angiotensin
41 apoptosis
42 apoptotic cardiomyocyte death
43 apoptotic cell death
44 area
45 arginine
46 arginine methyl ester
47 border
48 border zone
49 cardiomyocyte apoptosis
50 cardiomyocyte death
51 cell death
52 cells
53 center
54 changes
55 coronary occlusion
56 death
57 effect
58 enzyme gene expression
59 enzyme mRNA expression
60 esters
61 expression
62 female Sprague-Dawley rats
63 free wall
64 gene expression
65 group
66 h reperfusion
67 important pathogenic mechanism
68 index
69 inhibition
70 inhibitors
71 injury
72 ischemia/reperfusion injury
73 labeling index
74 left free wall
75 mRNA expression
76 marginal significance
77 mechanism
78 min coronary occlusion
79 modulation
80 myocardial angiotensin
81 myocardial apoptotic cell death
82 myocardial ischemia/reperfusion injury
83 myocardium
84 nick
85 nitric oxide
86 nitric oxide synthesis
87 observations
88 occlusion
89 oxide
90 oxide synthesis
91 pathogenic mechanisms
92 precursors
93 rats
94 renin-angiotensin system
95 reperfusion
96 reperfusion injury
97 significance
98 situ nick
99 study
100 synthesis
101 synthesis inhibitor
102 system
103 time
104 vehicle group
105 vehicles
106 wall
107 zone
108 schema:name Inhibition of nitric oxide synthesis increases apoptotic cardiomyocyte death and myocardial angiotensin-converting enzyme gene expression in ischemia/reperfusion-injured myocardium of rats
109 schema:pagination 12-19
110 schema:productId N77cf161d3d5d4b9284fcb9e283aa720d
111 Nca3b1e65e3404e0f874517bf239fb20b
112 Ne7ef9d1bc4984abd91645f88cb5a52d9
113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046583081
114 https://doi.org/10.1007/pl00007274
115 schema:sdDatePublished 2022-09-02T15:49
116 schema:sdLicense https://scigraph.springernature.com/explorer/license/
117 schema:sdPublisher N64782f3c8e62452fa41b6fc7fc8edc01
118 schema:url https://doi.org/10.1007/pl00007274
119 sgo:license sg:explorer/license/
120 sgo:sdDataset articles
121 rdf:type schema:ScholarlyArticle
122 N007972e8bb7e4f5ba7d477d52c8d6658 rdf:first sg:person.0634045514.10
123 rdf:rest N1a871f1ae7c54a71bdadfbedcc04a374
124 N10511ceca50c4f85beb9935839f593f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name In Situ Nick-End Labeling
126 rdf:type schema:DefinedTerm
127 N17f186bfe8fe4ee6b6b35600dae4e40f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Animals
129 rdf:type schema:DefinedTerm
130 N1a871f1ae7c54a71bdadfbedcc04a374 rdf:first Nc71c96ec6d18451ca8145bcb71aca818
131 rdf:rest N4700718b13f64e7493f6dfd2e74edff8
132 N1ae1310790b641188de138cd8dc1b9c2 rdf:first sg:person.01132635714.61
133 rdf:rest N6d1d43e14e734438ab5e893b70389900
134 N2cefa1b7956749dd8826597ba6610de4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Nitric Oxide
136 rdf:type schema:DefinedTerm
137 N3748981ad7d740dbbf2f67180b342a9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Myocardium
139 rdf:type schema:DefinedTerm
140 N380ba5cb3b2f45e6aaa744e1989943fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Reperfusion Injury
142 rdf:type schema:DefinedTerm
143 N3af43a21d11d413b9bf3b95e1eb797d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Random Allocation
145 rdf:type schema:DefinedTerm
146 N3da7ca5bc6294217823225958b9653d9 schema:affiliation grid-institutes:grid.31501.36
147 schema:familyName Kim
148 schema:givenName C.-H.
149 rdf:type schema:Person
150 N4700718b13f64e7493f6dfd2e74edff8 rdf:first sg:person.014376272237.54
151 rdf:rest Ndc97ddb1c8864fc4ac63e156229801c8
152 N4acc87b1d26d45d49004597e6f1cdaa2 rdf:first N3da7ca5bc6294217823225958b9653d9
153 rdf:rest N1ae1310790b641188de138cd8dc1b9c2
154 N5dac01144704497c99ff5de8c52fe64b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name RNA, Messenger
156 rdf:type schema:DefinedTerm
157 N64782f3c8e62452fa41b6fc7fc8edc01 schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 N6d1d43e14e734438ab5e893b70389900 rdf:first sg:person.01173564076.58
160 rdf:rest Nf853882f58e84159aa8e0e335447ddcd
161 N77cf161d3d5d4b9284fcb9e283aa720d schema:name pubmed_id
162 schema:value 11829213
163 rdf:type schema:PropertyValue
164 N790e841a00a344a7875167bb811d0354 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Female
166 rdf:type schema:DefinedTerm
167 N8ce4c8722958405fb79991920457866f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Statistics, Nonparametric
169 rdf:type schema:DefinedTerm
170 Nb4d9688608e84f9980a44527eaeb62cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Rats
172 rdf:type schema:DefinedTerm
173 Nb693b3c10e7245d0b7d3b595151edf32 rdf:first sg:person.01224452677.69
174 rdf:rest N4acc87b1d26d45d49004597e6f1cdaa2
175 Nc71c96ec6d18451ca8145bcb71aca818 schema:affiliation grid-institutes:grid.31501.36
176 schema:familyName Kim
177 schema:givenName C.-H.
178 rdf:type schema:Person
179 Nca3b1e65e3404e0f874517bf239fb20b schema:name dimensions_id
180 schema:value pub.1046583081
181 rdf:type schema:PropertyValue
182 Ndc97ddb1c8864fc4ac63e156229801c8 rdf:first sg:person.016513670520.65
183 rdf:rest Nb693b3c10e7245d0b7d3b595151edf32
184 Nde0b096fcdf6457780b924db3f39f657 schema:volumeNumber 16
185 rdf:type schema:PublicationVolume
186 Ne7ef9d1bc4984abd91645f88cb5a52d9 schema:name doi
187 schema:value 10.1007/pl00007274
188 rdf:type schema:PropertyValue
189 Nebe45cdd04d14532b5d98555c795788e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Rats, Sprague-Dawley
191 rdf:type schema:DefinedTerm
192 Neef61ddabc584686b31b483566e0b572 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Apoptosis
194 rdf:type schema:DefinedTerm
195 Nf37f8ab6849d45d78e5738e7c9a6a8e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Peptidyl-Dipeptidase A
197 rdf:type schema:DefinedTerm
198 Nf853882f58e84159aa8e0e335447ddcd rdf:first sg:person.0661601052.43
199 rdf:rest rdf:nil
200 Nfb86659ed70c4208aacf1ec3a234f989 schema:issueNumber 1
201 rdf:type schema:PublicationIssue
202 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
203 schema:name Medical and Health Sciences
204 rdf:type schema:DefinedTerm
205 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical Physiology
207 rdf:type schema:DefinedTerm
208 sg:journal.1095887 schema:issn 0910-8327
209 1615-2573
210 schema:name Heart and Vessels
211 schema:publisher Springer Nature
212 rdf:type schema:Periodical
213 sg:person.01132635714.61 schema:affiliation grid-institutes:grid.31501.36
214 schema:familyName Oh
215 schema:givenName B.-H.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132635714.61
217 rdf:type schema:Person
218 sg:person.01173564076.58 schema:affiliation grid-institutes:grid.31501.36
219 schema:familyName Lee
220 schema:givenName M.-M.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173564076.58
222 rdf:type schema:Person
223 sg:person.01224452677.69 schema:affiliation grid-institutes:grid.254229.a
224 schema:familyName Cho
225 schema:givenName M.-C.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224452677.69
227 rdf:type schema:Person
228 sg:person.014376272237.54 schema:affiliation grid-institutes:grid.31501.36
229 schema:familyName Kang
230 schema:givenName H.-J.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014376272237.54
232 rdf:type schema:Person
233 sg:person.016513670520.65 schema:affiliation grid-institutes:grid.254229.a
234 schema:familyName Kim
235 schema:givenName D.-W.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016513670520.65
237 rdf:type schema:Person
238 sg:person.0634045514.10 schema:affiliation grid-institutes:grid.254229.a
239 schema:familyName Youn
240 schema:givenName T.-J.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634045514.10
242 rdf:type schema:Person
243 sg:person.0661601052.43 schema:affiliation grid-institutes:grid.31501.36
244 schema:familyName Park
245 schema:givenName Y.-B.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661601052.43
247 rdf:type schema:Person
248 sg:pub.10.1007/bf02750637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000234020
249 https://doi.org/10.1007/bf02750637
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/s003950050068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029776488
252 https://doi.org/10.1007/s003950050068
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/s003950050149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015917721
255 https://doi.org/10.1007/s003950050149
256 rdf:type schema:CreativeWork
257 grid-institutes:grid.254229.a schema:alternateName Department of Internal Medicine and Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea, KR
258 schema:name Department of Internal Medicine and Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea, KR
259 rdf:type schema:Organization
260 grid-institutes:grid.31501.36 schema:alternateName Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR
261 schema:name Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea Tel. +82-2-760-2226; Fax +82-2-766-8904 e-mail: hyosoo@plaza.snu.ac.kr, KR
262 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...