Evolution of Substrate Specificities in the P-Type ATPase Superfamily View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-01

AUTHORS

Kristian B. Axelsen, Michael G. Palmgren

ABSTRACT

P-type ATPases make up a large superfamily of ATP-driven pumps involved in the transmembrane transport of charged substrates. We have performed an analysis of conserved core sequences in 159 P-type ATPases. The various ATPases group together in five major branches according to substrate specificity, and not according to the evolutionary relationship of the parental species, indicating that invention of new substrate specificities is accompanied by abrupt changes in the rate of sequence evolution. A hitherto-unrecognized family of P-type ATPases has been identified that is expected to be represented in all the major phyla of eukarya. More... »

PAGES

84-101

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/pl00006286

DOI

http://dx.doi.org/10.1007/pl00006286

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011413241

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9419228


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