Ontology type: schema:ScholarlyArticle
1997-09
AUTHORSR.P. Heaney, M.J. Barger-Lux, K.M. Davies, R.A. Ryan, M.L. Johnson, G. Gong
ABSTRACT: Changes in bony dimensions with age were assessed longitudinally from standardized X-ray films in 170 middle-aged Caucasian women, starting at age 40 years and with a median duration of observation of 21.125 years. Consistent with earlier work, cortical area of the metacarpals and radial shaft declined with age at rates ranging from 0.57 to 0.86%/year. As predicted, estrogen replacement therapy decreased this loss in a dose-dependent manner. Not previously reported is the fact that weight gain over the period of observation reduced upper extremity bone loss. Moreover, this protection was independent of the estrogen effect. In contrast with bone loss in the upper extremity, both femur shaft diameter and femur shaft cortical area increased significantly with age (0.23 and 0.26%/year, respectively). Estrogen replacement therapy inhibited femur shaft expansion but had no effect on femur cortical area. Weight change, however, strongly influenced gain (or loss) of femur cortical area: those in the highest weight change tertile gained 4 times as much cortical area as those in the lowest weight change tertile. VDR genotype also significantly influenced femoral shaft changes: women with the bb genotype had both greater shaft expansion and a greater increase in cortical area. The VDR effects were independent of the effects of weight change and estrogen. Femoral shaft expansion was of sufficient magnitude to suggest that the mechanical properties of the entire femur may change appreciably with age. Finally, contrary to widespread belief, there was significant, if modest, expansion at the femoral neck with age. More... »
PAGES426-431
http://scigraph.springernature.com/pub.10.1007/pl00004150
DOIhttp://dx.doi.org/10.1007/pl00004150
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1020774180
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/9425499
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Anthropometry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Body Weight",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone and Bones",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Estrogen Replacement Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Femur",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follow-Up Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiography",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Calcitriol",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US",
"id": "http://www.grid.ac/institutes/grid.254748.8",
"name": [
"Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US"
],
"type": "Organization"
},
"familyName": "Heaney",
"givenName": "R.P.",
"id": "sg:person.0645437522.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645437522.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US",
"id": "http://www.grid.ac/institutes/grid.254748.8",
"name": [
"Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US"
],
"type": "Organization"
},
"familyName": "Barger-Lux",
"givenName": "M.J.",
"id": "sg:person.0756143507.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756143507.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US",
"id": "http://www.grid.ac/institutes/grid.254748.8",
"name": [
"Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US"
],
"type": "Organization"
},
"familyName": "Davies",
"givenName": "K.M.",
"id": "sg:person.013331732212.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013331732212.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US",
"id": "http://www.grid.ac/institutes/grid.254748.8",
"name": [
"Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US"
],
"type": "Organization"
},
"familyName": "Ryan",
"givenName": "R.A.",
"id": "sg:person.0672212725.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672212725.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US",
"id": "http://www.grid.ac/institutes/grid.254748.8",
"name": [
"Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US"
],
"type": "Organization"
},
"familyName": "Johnson",
"givenName": "M.L.",
"id": "sg:person.01103633103.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103633103.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US",
"id": "http://www.grid.ac/institutes/grid.254748.8",
"name": [
"Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA, US"
],
"type": "Organization"
},
"familyName": "Gong",
"givenName": "G.",
"id": "sg:person.0634676576.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634676576.19"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf00297293",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003714224",
"https://doi.org/10.1007/bf00297293"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/367284a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032026902",
"https://doi.org/10.1038/367284a0"
],
"type": "CreativeWork"
}
],
"datePublished": "1997-09",
"datePublishedReg": "1997-09-01",
"description": "Abstract: Changes in bony dimensions with age were assessed longitudinally from standardized X-ray films in 170 middle-aged Caucasian women, starting at age 40 years and with a median duration of observation of 21.125 years. Consistent with earlier work, cortical area of the metacarpals and radial shaft declined with age at rates ranging from 0.57 to 0.86%/year. As predicted, estrogen replacement therapy decreased this loss in a dose-dependent manner. Not previously reported is the fact that weight gain over the period of observation reduced upper extremity bone loss. Moreover, this protection was independent of the estrogen effect. In contrast with bone loss in the upper extremity, both femur shaft diameter and femur shaft cortical area increased significantly with age (0.23 and 0.26%/year, respectively). Estrogen replacement therapy inhibited femur shaft expansion but had no effect on femur cortical area. Weight change, however, strongly influenced gain (or loss) of femur cortical area: those in the highest weight change tertile gained 4 times as much cortical area as those in the lowest weight change tertile. VDR genotype also significantly influenced femoral shaft changes: women with the bb genotype had both greater shaft expansion and a greater increase in cortical area. The VDR effects were independent of the effects of weight change and estrogen. Femoral shaft expansion was of sufficient magnitude to suggest that the mechanical properties of the entire femur may change appreciably with age. Finally, contrary to widespread belief, there was significant, if modest, expansion at the femoral neck with age.",
"genre": "article",
"id": "sg:pub.10.1007/pl00004150",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2371116",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1100834",
"issn": [
"0937-941X",
"1433-2965"
],
"name": "Osteoporosis International",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "5",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "7"
}
],
"keywords": [
"estrogen replacement therapy",
"cortical areas",
"replacement therapy",
"bone loss",
"weight change",
"bone dimensional changes",
"middle-aged Caucasian women",
"age 40 years",
"dose-dependent manner",
"X-ray films",
"median duration",
"VDR genotype",
"estrogen effects",
"femoral neck",
"Caucasian women",
"upper extremity",
"radial shaft",
"VDR effect",
"period of observation",
"entire femur",
"bony dimensions",
"body size variables",
"interaction of genetics",
"age",
"therapy",
"greater increase",
"BB genotype",
"women",
"tertile",
"estrogen",
"years",
"Hormonal",
"extremities",
"neck",
"sufficient magnitude",
"genotypes",
"femur",
"metacarpal",
"effect",
"shaft changes",
"changes",
"loss",
"duration",
"shaft diameter",
"period",
"low weight change",
"area",
"weight",
"rate",
"increase",
"contrast",
"protection",
"manner",
"widespread belief",
"genetics",
"observations",
"variables",
"time",
"dimensional changes",
"gain",
"expansion",
"diameter",
"beliefs",
"shaft",
"size variables",
"interaction",
"magnitude",
"fact",
"shaft expansion",
"dimensions",
"work",
"earlier work",
"properties",
"mechanical properties",
"films"
],
"name": "Bone Dimensional Change with Age: Interactions of Genetic, Hormonal, and Body Size Variables",
"pagination": "426-431",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1020774180"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/pl00004150"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"9425499"
]
}
],
"sameAs": [
"https://doi.org/10.1007/pl00004150",
"https://app.dimensions.ai/details/publication/pub.1020774180"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:52",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_284.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/pl00004150"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/pl00004150'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/pl00004150'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/pl00004150'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/pl00004150'
This table displays all metadata directly associated to this object as RDF triples.
237 TRIPLES
21 PREDICATES
117 URIs
107 LITERALS
21 BLANK NODES