Trace Element Homeostasis During Continuous Sedation With Propofol Containing EDTA Versus Other Sedatives in Critically Ill Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-12

AUTHORS

T. L. Higgins, Michael Murray, Daniel H. Kett, Gerard Fulda, Katherine M. Kramer, David Gelmont, Harakh V. Dedhia, Howard Levy, Daniel Teres, Gary P. Zaloga, Haumei Ko, Karen A. Thompson

ABSTRACT

OBJECTIVE: To evaluate changes in serum and urinary zinc, cobalt, copper, iron, and calcium concentrations in critically ill patients receiving propofol containing disodium edetate (disodium ethylenediaminetetraacetic acid [EDTA]) versus sedative agents without EDTA. DESIGN: This was a randomised, open-label, parallel-group study with randomisation stratified by baseline Acute Physiology and Chronic Health Evaluation (APACHE II) scores. SETTING: Intensive care units (ICU) in 23 medical centres. PATIENTS: Medical, surgical, or trauma ICU patients 17 years of age or older who required mechanical ventilator support and sedation. INTERVENTIONS: A total of 106 patients received propofol containing 0.005 % EDTA (propofol EDTA), and 104 received other sedative agents without EDTA (non-EDTA). Only the first 108 patients were assessed for urinary trace metal excretion. Twenty-four-hour urine samples were collected on days 2, 3, and 7 and every 7 days thereafter for determination of zinc, cobalt, copper, iron, and calcium excretion; EDTA levels; urine osmolality; albumin levels; and glucose levels. The first 143 patients were assessed for serum concentration of zinc, cobalt, copper, iron, and calcium; creatinine; blood urea nitrogen; and albumin at baseline and once during each 24-hour urine collection. MEASUREMENTS AND RESULTS: For the assessment of trace metals, patients receiving propofol EDTA demonstrated increased mean urinary excretion of zinc, copper, and iron compared with the normal range. All patients receiving sedatives demonstrated increased urinary excretion of zinc and copper above normal reference values. Compared with the non-EDTA sedative group, the propofol EDTA group demonstrated increased urinary excretion of zinc and iron. Mean serum concentrations of zinc and total calcium were decreased in both patient groups. Serum zinc concentrations increased from baseline to day 3 in the non-EDTA sedative group but not in the propofol EDTA group. Renal function, measured by blood urea nitrogen, serum creatinine, and creatinine clearance, did not deteriorate during ICU sedation with either regimen. CONCLUSION: This study showed that critical illness is associated with increased urinary losses of zinc, copper, and iron. Propofol EDTA-treated patients had greater urinary losses of zinc and iron and lower serum zinc concentrations compared with the non-EDTA sedative group. No adverse events indicative of trace metal deficiency were observed in either group. The clinical significance of trace metal losses during critical illness is unclear and requires further study. More... »

PAGES

s413-s421

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/pl00003785

DOI

http://dx.doi.org/10.1007/pl00003785

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030552269

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11310904


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "APACHE", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anesthetics, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chelating Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chi-Square Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Critical Illness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Edetic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemodynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Odds Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Preservatives, Pharmaceutical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Propofol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Statistics, Nonparametric", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trace Elements", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Baystate Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.281162.e", 
          "name": [
            "Critical Care Division,  Baystate Medical Center,  759 Chestnut Street, Springfield, MA 01199 Tel.: + 4 13-7 94-54 39"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Higgins", 
        "givenName": "T. L.", 
        "id": "sg:person.01275476720.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275476720.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Mayo Clinic, Rochester, MN"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murray", 
        "givenName": "Michael", 
        "id": "sg:person.01100203023.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100203023.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Miami", 
          "id": "https://www.grid.ac/institutes/grid.26790.3a", 
          "name": [
            "University of Miami School of Medicine, Miami, FL"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kett", 
        "givenName": "Daniel H.", 
        "id": "sg:person.0656500517.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656500517.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Christiana Care Health System", 
          "id": "https://www.grid.ac/institutes/grid.414316.5", 
          "name": [
            "Christiana Care Health Services, Newark, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fulda", 
        "givenName": "Gerard", 
        "id": "sg:person.01065527047.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065527047.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University of New Mexico College of Pharmacy, Albuquerque, NM, MX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kramer", 
        "givenName": "Katherine M.", 
        "id": "sg:person.01262544623.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262544623.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "University of Southern California,  Los Angeles, CA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gelmont", 
        "givenName": "David", 
        "id": "sg:person.01330660023.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330660023.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West Virginia University", 
          "id": "https://www.grid.ac/institutes/grid.268154.c", 
          "name": [
            "West Virginia University School of Medicine, Morgantown, WV"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dedhia", 
        "givenName": "Harakh V.", 
        "id": "sg:person.01054547631.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054547631.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University of New Mexico, Albuquerque, NM, MX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levy", 
        "givenName": "Howard", 
        "id": "sg:person.0653367123.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653367123.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AstraZeneca (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418152.b", 
          "name": [
            "AstraZeneca, Wilmington, DE,  Tufts University School of Medicine, Boston, MA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teres", 
        "givenName": "Daniel", 
        "id": "sg:person.01121561040.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121561040.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Suburban Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416674.6", 
          "name": [
            "Suburban Hospital, Bethesda, MD"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zaloga", 
        "givenName": "Gary P.", 
        "id": "sg:person.0733106443.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733106443.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AstraZeneca (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418152.b", 
          "name": [
            "AstraZeneca, Wilmington, Delaware"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ko", 
        "givenName": "Haumei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AstraZeneca (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418152.b", 
          "name": [
            "AstraZeneca, Wilmington, Delaware"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Karen A.", 
        "id": "sg:person.01104044123.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104044123.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0025-7125(16)31864-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006544423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-197604000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007553464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-197604000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007553464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.7.3408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025105302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.1975.00490530067006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029032008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4800(78)90052-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035834392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0048-9697(98)00158-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043034495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00003784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044173831", 
          "https://doi.org/10.1007/pl00003784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00003786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047573735", 
          "https://doi.org/10.1007/pl00003786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.1991.tb05541.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048560572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-595x(85)80005-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053390414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ed036p555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055440783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/515549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058789938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/clinids/3.6.1127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059474652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.2.0224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.2.0224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1986.64.2.0224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071094232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-133-4-200008150-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073704295"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-12", 
    "datePublishedReg": "2000-12-01", 
    "description": "OBJECTIVE: To evaluate changes in serum and urinary zinc, cobalt, copper, iron, and calcium concentrations in critically ill patients receiving propofol containing disodium edetate (disodium ethylenediaminetetraacetic acid [EDTA]) versus sedative agents without EDTA.\nDESIGN: This was a randomised, open-label, parallel-group study with randomisation stratified by baseline Acute Physiology and Chronic Health Evaluation (APACHE II) scores.\nSETTING: Intensive care units (ICU) in 23 medical centres.\nPATIENTS: Medical, surgical, or trauma ICU patients 17 years of age or older who required mechanical ventilator support and sedation.\nINTERVENTIONS: A total of 106 patients received propofol containing 0.005 % EDTA (propofol EDTA), and 104 received other sedative agents without EDTA (non-EDTA). Only the first 108 patients were assessed for urinary trace metal excretion. Twenty-four-hour urine samples were collected on days 2, 3, and 7 and every 7 days thereafter for determination of zinc, cobalt, copper, iron, and calcium excretion; EDTA levels; urine osmolality; albumin levels; and glucose levels. The first 143 patients were assessed for serum concentration of zinc, cobalt, copper, iron, and calcium; creatinine; blood urea nitrogen; and albumin at baseline and once during each 24-hour urine collection.\nMEASUREMENTS AND RESULTS: For the assessment of trace metals, patients receiving propofol EDTA demonstrated increased mean urinary excretion of zinc, copper, and iron compared with the normal range. All patients receiving sedatives demonstrated increased urinary excretion of zinc and copper above normal reference values. Compared with the non-EDTA sedative group, the propofol EDTA group demonstrated increased urinary excretion of zinc and iron. Mean serum concentrations of zinc and total calcium were decreased in both patient groups. Serum zinc concentrations increased from baseline to day 3 in the non-EDTA sedative group but not in the propofol EDTA group. Renal function, measured by blood urea nitrogen, serum creatinine, and creatinine clearance, did not deteriorate during ICU sedation with either regimen.\nCONCLUSION: This study showed that critical illness is associated with increased urinary losses of zinc, copper, and iron. Propofol EDTA-treated patients had greater urinary losses of zinc and iron and lower serum zinc concentrations compared with the non-EDTA sedative group. No adverse events indicative of trace metal deficiency were observed in either group. The clinical significance of trace metal losses during critical illness is unclear and requires further study.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/pl00003785", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1313639", 
        "issn": [
          "0342-4642", 
          "1432-1238"
        ], 
        "name": "Intensive Care Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "Suppl 3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "Trace Element Homeostasis During Continuous Sedation With Propofol Containing EDTA Versus Other Sedatives in Critically Ill Patients", 
    "pagination": "s413-s421", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "918bfd5c21b0e9c0c61464050a65c589d848047deff9155bb34c557ce156f465"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11310904"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7704851"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/pl00003785"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030552269"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/pl00003785", 
      "https://app.dimensions.ai/details/publication/pub.1030552269"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000481.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/PL00003785"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/pl00003785'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/pl00003785'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/pl00003785'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/pl00003785'


 

This table displays all metadata directly associated to this object as RDF triples.

306 TRIPLES      21 PREDICATES      66 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/pl00003785 schema:about N07c1db38c8b84ad19e40164d350e7158
2 N1bc1d10c6c7145a8a98b6f2a186a1ca5
3 N1d3dec0497924d6286d3019f99ea1fae
4 N1fad58a39e12460b81eb46fdc64fded1
5 N1fdeb588f036469684768d2fd5aa81d7
6 N27da772384ef4e6a900a4220654f5bb7
7 N34e2075493e34daba3145d1e444cad8c
8 N4a5ceba0340e4e4f81faa0e035b40bed
9 N75b4d03e41d14d7887127c6850486741
10 N795797d71af944358283eedf13b48f2a
11 N87ef409a4c8d47dcacbd146e72241473
12 N9faabefd24174228a281ac28a6bfaa65
13 Na978d8bf322047b0aa409835c81dd4c5
14 Nbb298f75dba9412b9005339fe9c2739e
15 Nc33a403ce1d649dcbc7780bf40423f2e
16 Nc9e43fc56a4c46a3b4831e1a9908783b
17 Nca0e4ffad0404046a5bc31de5572fa4c
18 Ncef11f4870a5454ea9c9ca97c8fb30eb
19 Nd04c2285f8764be7bfc4e5e521ce2fb6
20 Nd20b881dfe104e98a7aa2203955ea605
21 Nd2e16c1af5fd4ab0b97417a72b2d0b67
22 Nec083e5bf7ac4d1cb732a05490583d89
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author Na9e85a722a5d4b1f941f17eea4cf8021
26 schema:citation sg:pub.10.1007/pl00003784
27 sg:pub.10.1007/pl00003786
28 https://doi.org/10.1001/archneur.1975.00490530067006
29 https://doi.org/10.1016/0014-4800(78)90052-7
30 https://doi.org/10.1016/s0025-7125(16)31864-8
31 https://doi.org/10.1016/s0048-9697(98)00158-2
32 https://doi.org/10.1016/s0300-595x(85)80005-0
33 https://doi.org/10.1021/ed036p555
34 https://doi.org/10.1073/pnas.95.7.3408
35 https://doi.org/10.1086/515549
36 https://doi.org/10.1093/clinids/3.6.1127
37 https://doi.org/10.1097/00000658-197604000-00001
38 https://doi.org/10.1111/j.1365-2125.1991.tb05541.x
39 https://doi.org/10.3171/jns.1986.64.2.0224
40 https://doi.org/10.7326/0003-4819-133-4-200008150-00006
41 schema:datePublished 2000-12
42 schema:datePublishedReg 2000-12-01
43 schema:description OBJECTIVE: To evaluate changes in serum and urinary zinc, cobalt, copper, iron, and calcium concentrations in critically ill patients receiving propofol containing disodium edetate (disodium ethylenediaminetetraacetic acid [EDTA]) versus sedative agents without EDTA. DESIGN: This was a randomised, open-label, parallel-group study with randomisation stratified by baseline Acute Physiology and Chronic Health Evaluation (APACHE II) scores. SETTING: Intensive care units (ICU) in 23 medical centres. PATIENTS: Medical, surgical, or trauma ICU patients 17 years of age or older who required mechanical ventilator support and sedation. INTERVENTIONS: A total of 106 patients received propofol containing 0.005 % EDTA (propofol EDTA), and 104 received other sedative agents without EDTA (non-EDTA). Only the first 108 patients were assessed for urinary trace metal excretion. Twenty-four-hour urine samples were collected on days 2, 3, and 7 and every 7 days thereafter for determination of zinc, cobalt, copper, iron, and calcium excretion; EDTA levels; urine osmolality; albumin levels; and glucose levels. The first 143 patients were assessed for serum concentration of zinc, cobalt, copper, iron, and calcium; creatinine; blood urea nitrogen; and albumin at baseline and once during each 24-hour urine collection. MEASUREMENTS AND RESULTS: For the assessment of trace metals, patients receiving propofol EDTA demonstrated increased mean urinary excretion of zinc, copper, and iron compared with the normal range. All patients receiving sedatives demonstrated increased urinary excretion of zinc and copper above normal reference values. Compared with the non-EDTA sedative group, the propofol EDTA group demonstrated increased urinary excretion of zinc and iron. Mean serum concentrations of zinc and total calcium were decreased in both patient groups. Serum zinc concentrations increased from baseline to day 3 in the non-EDTA sedative group but not in the propofol EDTA group. Renal function, measured by blood urea nitrogen, serum creatinine, and creatinine clearance, did not deteriorate during ICU sedation with either regimen. CONCLUSION: This study showed that critical illness is associated with increased urinary losses of zinc, copper, and iron. Propofol EDTA-treated patients had greater urinary losses of zinc and iron and lower serum zinc concentrations compared with the non-EDTA sedative group. No adverse events indicative of trace metal deficiency were observed in either group. The clinical significance of trace metal losses during critical illness is unclear and requires further study.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree false
47 schema:isPartOf N02acf4117f0b4272aaaab4b693a9253d
48 N81955479314b427cad707123b022dfca
49 sg:journal.1313639
50 schema:name Trace Element Homeostasis During Continuous Sedation With Propofol Containing EDTA Versus Other Sedatives in Critically Ill Patients
51 schema:pagination s413-s421
52 schema:productId N40b6de1955c342a6b3f4baa22ad64b5b
53 N5005a60ff64a4654b2a796853fe1e345
54 N64ba811f984b48589d6dbb29a5da4549
55 N96545968cf9b4cdf993d2ad0ac8f783c
56 Nb8e21ba0e3004e179aff5cb9992c4f22
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030552269
58 https://doi.org/10.1007/pl00003785
59 schema:sdDatePublished 2019-04-10T14:01
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N5b2cf5badef843d5808e6d43eec01705
62 schema:url http://link.springer.com/10.1007/PL00003785
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N02acf4117f0b4272aaaab4b693a9253d schema:volumeNumber 26
67 rdf:type schema:PublicationVolume
68 N071cea4bfc7e4714b71a68a07f5564d6 rdf:first sg:person.0733106443.46
69 rdf:rest N2b3b1e16f5a84b3ba58008ed0f10f035
70 N07c1db38c8b84ad19e40164d350e7158 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name APACHE
72 rdf:type schema:DefinedTerm
73 N14c761e5d2424b0eb5d44b85262c6bb0 rdf:first sg:person.01065527047.08
74 rdf:rest N3ae053d5bb5d4f789bcb0b85a57286db
75 N170dc9383216474298a9a8845251ccdf rdf:first sg:person.01330660023.17
76 rdf:rest Ne305568040184246901d4eb6cfcc04d7
77 N180afdc6420f471aa49808ee579880ec rdf:first sg:person.0653367123.62
78 rdf:rest N2f79ae56e02a4018a1e17a4c9ec37fd7
79 N1bc1d10c6c7145a8a98b6f2a186a1ca5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Adolescent
81 rdf:type schema:DefinedTerm
82 N1d3dec0497924d6286d3019f99ea1fae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Aged, 80 and over
84 rdf:type schema:DefinedTerm
85 N1fad58a39e12460b81eb46fdc64fded1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Adult
87 rdf:type schema:DefinedTerm
88 N1fdeb588f036469684768d2fd5aa81d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Preservatives, Pharmaceutical
90 rdf:type schema:DefinedTerm
91 N27da772384ef4e6a900a4220654f5bb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Anesthetics, Intravenous
93 rdf:type schema:DefinedTerm
94 N2b3b1e16f5a84b3ba58008ed0f10f035 rdf:first N918ac5e4780d4cd081b4fd4a7383300e
95 rdf:rest Nfc9601b1e77247af991e8cf3c98f7ff2
96 N2f79ae56e02a4018a1e17a4c9ec37fd7 rdf:first sg:person.01121561040.77
97 rdf:rest N071cea4bfc7e4714b71a68a07f5564d6
98 N34e2075493e34daba3145d1e444cad8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Trace Elements
100 rdf:type schema:DefinedTerm
101 N3ae053d5bb5d4f789bcb0b85a57286db rdf:first sg:person.01262544623.03
102 rdf:rest N170dc9383216474298a9a8845251ccdf
103 N40b6de1955c342a6b3f4baa22ad64b5b schema:name pubmed_id
104 schema:value 11310904
105 rdf:type schema:PropertyValue
106 N4a5ceba0340e4e4f81faa0e035b40bed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Critical Illness
108 rdf:type schema:DefinedTerm
109 N5005a60ff64a4654b2a796853fe1e345 schema:name dimensions_id
110 schema:value pub.1030552269
111 rdf:type schema:PropertyValue
112 N590351017342431bbe5194670ae42ece rdf:first sg:person.01100203023.83
113 rdf:rest N68610eee087d4470958a3e32624f35d7
114 N5b2cf5badef843d5808e6d43eec01705 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N64ba811f984b48589d6dbb29a5da4549 schema:name readcube_id
117 schema:value 918bfd5c21b0e9c0c61464050a65c589d848047deff9155bb34c557ce156f465
118 rdf:type schema:PropertyValue
119 N68610eee087d4470958a3e32624f35d7 rdf:first sg:person.0656500517.09
120 rdf:rest N14c761e5d2424b0eb5d44b85262c6bb0
121 N75b4d03e41d14d7887127c6850486741 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Statistics, Nonparametric
123 rdf:type schema:DefinedTerm
124 N795797d71af944358283eedf13b48f2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Edetic Acid
126 rdf:type schema:DefinedTerm
127 N81955479314b427cad707123b022dfca schema:issueNumber Suppl 3
128 rdf:type schema:PublicationIssue
129 N87ef409a4c8d47dcacbd146e72241473 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Hemodynamics
131 rdf:type schema:DefinedTerm
132 N918ac5e4780d4cd081b4fd4a7383300e schema:affiliation https://www.grid.ac/institutes/grid.418152.b
133 schema:familyName Ko
134 schema:givenName Haumei
135 rdf:type schema:Person
136 N96545968cf9b4cdf993d2ad0ac8f783c schema:name nlm_unique_id
137 schema:value 7704851
138 rdf:type schema:PropertyValue
139 N9bdb31e7966440459329872aae0252fd schema:name University of New Mexico College of Pharmacy, Albuquerque, NM, MX
140 rdf:type schema:Organization
141 N9faabefd24174228a281ac28a6bfaa65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Odds Ratio
143 rdf:type schema:DefinedTerm
144 Na6639ee228b049dd9a7cd6cfd7065f4a schema:name University of New Mexico, Albuquerque, NM, MX
145 rdf:type schema:Organization
146 Na978d8bf322047b0aa409835c81dd4c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Humans
148 rdf:type schema:DefinedTerm
149 Na9e85a722a5d4b1f941f17eea4cf8021 rdf:first sg:person.01275476720.61
150 rdf:rest N590351017342431bbe5194670ae42ece
151 Nb8e21ba0e3004e179aff5cb9992c4f22 schema:name doi
152 schema:value 10.1007/pl00003785
153 rdf:type schema:PropertyValue
154 Nbb298f75dba9412b9005339fe9c2739e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Female
156 rdf:type schema:DefinedTerm
157 Nc33a403ce1d649dcbc7780bf40423f2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Chi-Square Distribution
159 rdf:type schema:DefinedTerm
160 Nc9e43fc56a4c46a3b4831e1a9908783b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Chelating Agents
162 rdf:type schema:DefinedTerm
163 Nca0e4ffad0404046a5bc31de5572fa4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Propofol
165 rdf:type schema:DefinedTerm
166 Ncef11f4870a5454ea9c9ca97c8fb30eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Male
168 rdf:type schema:DefinedTerm
169 Nd04c2285f8764be7bfc4e5e521ce2fb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Prospective Studies
171 rdf:type schema:DefinedTerm
172 Nd20b881dfe104e98a7aa2203955ea605 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Calcium
174 rdf:type schema:DefinedTerm
175 Nd2e16c1af5fd4ab0b97417a72b2d0b67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Aged
177 rdf:type schema:DefinedTerm
178 Ne305568040184246901d4eb6cfcc04d7 rdf:first sg:person.01054547631.44
179 rdf:rest N180afdc6420f471aa49808ee579880ec
180 Nec083e5bf7ac4d1cb732a05490583d89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Middle Aged
182 rdf:type schema:DefinedTerm
183 Nfc9601b1e77247af991e8cf3c98f7ff2 rdf:first sg:person.01104044123.09
184 rdf:rest rdf:nil
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
189 schema:name Clinical Sciences
190 rdf:type schema:DefinedTerm
191 sg:journal.1313639 schema:issn 0342-4642
192 1432-1238
193 schema:name Intensive Care Medicine
194 rdf:type schema:Periodical
195 sg:person.01054547631.44 schema:affiliation https://www.grid.ac/institutes/grid.268154.c
196 schema:familyName Dedhia
197 schema:givenName Harakh V.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054547631.44
199 rdf:type schema:Person
200 sg:person.01065527047.08 schema:affiliation https://www.grid.ac/institutes/grid.414316.5
201 schema:familyName Fulda
202 schema:givenName Gerard
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065527047.08
204 rdf:type schema:Person
205 sg:person.01100203023.83 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
206 schema:familyName Murray
207 schema:givenName Michael
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100203023.83
209 rdf:type schema:Person
210 sg:person.01104044123.09 schema:affiliation https://www.grid.ac/institutes/grid.418152.b
211 schema:familyName Thompson
212 schema:givenName Karen A.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104044123.09
214 rdf:type schema:Person
215 sg:person.01121561040.77 schema:affiliation https://www.grid.ac/institutes/grid.418152.b
216 schema:familyName Teres
217 schema:givenName Daniel
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121561040.77
219 rdf:type schema:Person
220 sg:person.01262544623.03 schema:affiliation N9bdb31e7966440459329872aae0252fd
221 schema:familyName Kramer
222 schema:givenName Katherine M.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262544623.03
224 rdf:type schema:Person
225 sg:person.01275476720.61 schema:affiliation https://www.grid.ac/institutes/grid.281162.e
226 schema:familyName Higgins
227 schema:givenName T. L.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275476720.61
229 rdf:type schema:Person
230 sg:person.01330660023.17 schema:affiliation https://www.grid.ac/institutes/grid.42505.36
231 schema:familyName Gelmont
232 schema:givenName David
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330660023.17
234 rdf:type schema:Person
235 sg:person.0653367123.62 schema:affiliation Na6639ee228b049dd9a7cd6cfd7065f4a
236 schema:familyName Levy
237 schema:givenName Howard
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653367123.62
239 rdf:type schema:Person
240 sg:person.0656500517.09 schema:affiliation https://www.grid.ac/institutes/grid.26790.3a
241 schema:familyName Kett
242 schema:givenName Daniel H.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656500517.09
244 rdf:type schema:Person
245 sg:person.0733106443.46 schema:affiliation https://www.grid.ac/institutes/grid.416674.6
246 schema:familyName Zaloga
247 schema:givenName Gary P.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733106443.46
249 rdf:type schema:Person
250 sg:pub.10.1007/pl00003784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044173831
251 https://doi.org/10.1007/pl00003784
252 rdf:type schema:CreativeWork
253 sg:pub.10.1007/pl00003786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047573735
254 https://doi.org/10.1007/pl00003786
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1001/archneur.1975.00490530067006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029032008
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/0014-4800(78)90052-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035834392
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0025-7125(16)31864-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006544423
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s0048-9697(98)00158-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043034495
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/s0300-595x(85)80005-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053390414
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1021/ed036p555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055440783
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1073/pnas.95.7.3408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025105302
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1086/515549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058789938
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1093/clinids/3.6.1127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059474652
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1097/00000658-197604000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007553464
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1111/j.1365-2125.1991.tb05541.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048560572
277 rdf:type schema:CreativeWork
278 https://doi.org/10.3171/jns.1986.64.2.0224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071094232
279 rdf:type schema:CreativeWork
280 https://doi.org/10.7326/0003-4819-133-4-200008150-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073704295
281 rdf:type schema:CreativeWork
282 https://www.grid.ac/institutes/grid.26790.3a schema:alternateName University of Miami
283 schema:name University of Miami School of Medicine, Miami, FL
284 rdf:type schema:Organization
285 https://www.grid.ac/institutes/grid.268154.c schema:alternateName West Virginia University
286 schema:name West Virginia University School of Medicine, Morgantown, WV
287 rdf:type schema:Organization
288 https://www.grid.ac/institutes/grid.281162.e schema:alternateName Baystate Medical Center
289 schema:name Critical Care Division, Baystate Medical Center, 759 Chestnut Street, Springfield, MA 01199 Tel.: + 4 13-7 94-54 39
290 rdf:type schema:Organization
291 https://www.grid.ac/institutes/grid.414316.5 schema:alternateName Christiana Care Health System
292 schema:name Christiana Care Health Services, Newark, DE
293 rdf:type schema:Organization
294 https://www.grid.ac/institutes/grid.416674.6 schema:alternateName Suburban Hospital
295 schema:name Suburban Hospital, Bethesda, MD
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.418152.b schema:alternateName AstraZeneca (United States)
298 schema:name AstraZeneca, Wilmington, DE, Tufts University School of Medicine, Boston, MA
299 AstraZeneca, Wilmington, Delaware
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.42505.36 schema:alternateName University of Southern California
302 schema:name University of Southern California, Los Angeles, CA
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
305 schema:name Mayo Clinic, Rochester, MN
306 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...