Genpolymorphismen der Hämostase und Koronarrisiko View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-04

AUTHORS

Peter Hellstern, Jürgen Bach, Hannelore Haubelt, Alexandra Preiss, Bernhard Rudolf Winkelmann, Jochen Senges

ABSTRACT

Hemostatic disorders are substantially involved in the pathogenesis of coronary heart disease and acute coronary syndromes. In addition to biochemical markers, gene polymorphisms of hemostasis have been intensively studied in terms of their association with coronary risk. These include polymorphisms of the genes of platelet glycoproteins, fibrinogen, prothrombin, factors V, VIII and XIII, plasminogen activator inhibitor-1 and tissue-type plasminogen activator. An association of a certain gene polymorphism with an increased coronary risk has usually been demonstrated in retrospective case-control studies. However, numerous clinical studies have not yet been able to identify any of these polymorphisms as unequivocal risk factors of coronary heart disease or acute coronary syndromes. These inconsistencies are mainly due to the complexity of the pathogenesis of coronary heart disease and the minor contribution of a single polymorphism to total coronary risk. This review reports on essential requirements of future studies as a prerequisite to improve our understanding of the genetic basis of coronary heart disease. More... »

PAGES

217-227

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/pl00002197

DOI

http://dx.doi.org/10.1007/pl00002197

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034463527

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11370604


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