Genpolymorphismen der Hämostase und Koronarrisiko View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-04

AUTHORS

Peter Hellstern, Jürgen Bach, Hannelore Haubelt, Alexandra Preiss, Bernhard Rudolf Winkelmann, Jochen Senges

ABSTRACT

Hemostatic disorders are substantially involved in the pathogenesis of coronary heart disease and acute coronary syndromes. In addition to biochemical markers, gene polymorphisms of hemostasis have been intensively studied in terms of their association with coronary risk. These include polymorphisms of the genes of platelet glycoproteins, fibrinogen, prothrombin, factors V, VIII and XIII, plasminogen activator inhibitor-1 and tissue-type plasminogen activator. An association of a certain gene polymorphism with an increased coronary risk has usually been demonstrated in retrospective case-control studies. However, numerous clinical studies have not yet been able to identify any of these polymorphisms as unequivocal risk factors of coronary heart disease or acute coronary syndromes. These inconsistencies are mainly due to the complexity of the pathogenesis of coronary heart disease and the minor contribution of a single polymorphism to total coronary risk. This review reports on essential requirements of future studies as a prerequisite to improve our understanding of the genetic basis of coronary heart disease. More... »

PAGES

217-227

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/pl00002197

DOI

http://dx.doi.org/10.1007/pl00002197

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034463527

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11370604


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Coagulation Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemostasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Institut f\u00fcr H\u00e4mostaseologie und Transfusionsmedizin, Klinikum Ludwigshafen, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hellstern", 
        "givenName": "Peter", 
        "id": "sg:person.0721160742.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721160742.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Institut f\u00fcr H\u00e4mostaseologie und Transfusionsmedizin, Klinikum Ludwigshafen, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bach", 
        "givenName": "J\u00fcrgen", 
        "id": "sg:person.012155212702.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012155212702.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Institut f\u00fcr H\u00e4mostaseologie und Transfusionsmedizin, Klinikum Ludwigshafen, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haubelt", 
        "givenName": "Hannelore", 
        "id": "sg:person.01200045035.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200045035.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Institut f\u00fcr H\u00e4mostaseologie und Transfusionsmedizin, Klinikum Ludwigshafen, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Preiss", 
        "givenName": "Alexandra", 
        "id": "sg:person.01061540141.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061540141.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Herzzentrum, Klinikum Ludwigshafen, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winkelmann", 
        "givenName": "Bernhard Rudolf", 
        "id": "sg:person.01160622567.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160622567.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Herzzentrum, Klinikum Ludwigshafen, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Senges", 
        "givenName": "Jochen", 
        "id": "sg:person.01201414614.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201414614.08"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2001-04", 
    "datePublishedReg": "2001-04-01", 
    "description": "Hemostatic disorders are substantially involved in the pathogenesis of coronary heart disease and acute coronary syndromes. In addition to biochemical markers, gene polymorphisms of hemostasis have been intensively studied in terms of their association with coronary risk. These include polymorphisms of the genes of platelet glycoproteins, fibrinogen, prothrombin, factors V, VIII and XIII, plasminogen activator inhibitor-1 and tissue-type plasminogen activator. An association of a certain gene polymorphism with an increased coronary risk has usually been demonstrated in retrospective case-control studies. However, numerous clinical studies have not yet been able to identify any of these polymorphisms as unequivocal risk factors of coronary heart disease or acute coronary syndromes. These inconsistencies are mainly due to the complexity of the pathogenesis of coronary heart disease and the minor contribution of a single polymorphism to total coronary risk. This review reports on essential requirements of future studies as a prerequisite to improve our understanding of the genetic basis of coronary heart disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/pl00002197", 
    "inLanguage": [
      "de"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017977", 
        "issn": [
          "0723-5003", 
          "1615-6722"
        ], 
        "name": "Medizinische Klinik", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "96"
      }
    ], 
    "name": "Genpolymorphismen der H\u00e4mostase und Koronarrisiko", 
    "pagination": "217-227", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a42bf02dec414fe8b9ea7d573482f8764c2a8fd4d26eebee01294ccb8d0941cd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11370604"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8303501"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/pl00002197"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034463527"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/pl00002197", 
      "https://app.dimensions.ai/details/publication/pub.1034463527"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2FPL00002197"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/pl00002197'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/pl00002197'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/pl00002197'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/pl00002197'


 

This table displays all metadata directly associated to this object as RDF triples.

137 TRIPLES      20 PREDICATES      37 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/pl00002197 schema:about N00b020aba9944fb4956f4d576188f872
2 N2fc17ba5308a4f9789cff9ea4bd3f401
3 N4d90bc788a774ec4a3c59e50943d14f3
4 N6df43b0354074b20971ee6f311e3d714
5 N83fb552da21c489a978e031afe12c39a
6 Nb608cabaad2749ca972ff211cf4f808f
7 Nb7790667463e4aff9683920f49bb0eeb
8 Nd578971950744ab7b56d302f8af784bb
9 anzsrc-for:11
10 anzsrc-for:1102
11 schema:author Ndf5b12da57be418b981cde9bfe3ca03e
12 schema:datePublished 2001-04
13 schema:datePublishedReg 2001-04-01
14 schema:description Hemostatic disorders are substantially involved in the pathogenesis of coronary heart disease and acute coronary syndromes. In addition to biochemical markers, gene polymorphisms of hemostasis have been intensively studied in terms of their association with coronary risk. These include polymorphisms of the genes of platelet glycoproteins, fibrinogen, prothrombin, factors V, VIII and XIII, plasminogen activator inhibitor-1 and tissue-type plasminogen activator. An association of a certain gene polymorphism with an increased coronary risk has usually been demonstrated in retrospective case-control studies. However, numerous clinical studies have not yet been able to identify any of these polymorphisms as unequivocal risk factors of coronary heart disease or acute coronary syndromes. These inconsistencies are mainly due to the complexity of the pathogenesis of coronary heart disease and the minor contribution of a single polymorphism to total coronary risk. This review reports on essential requirements of future studies as a prerequisite to improve our understanding of the genetic basis of coronary heart disease.
15 schema:genre research_article
16 schema:inLanguage de
17 schema:isAccessibleForFree false
18 schema:isPartOf N577ef0a3dd2a41aa980715d78f8070f3
19 N8b5605d42e974a12921792442ddf4534
20 sg:journal.1017977
21 schema:name Genpolymorphismen der Hämostase und Koronarrisiko
22 schema:pagination 217-227
23 schema:productId N1827d400018643a186912cab8ba2cb79
24 N2fea98feeb8c4b98b037274946017bda
25 N79203acd47764c928e73e7ba4c79b07a
26 Nc8f2448e9aec4ddbb8f20295f20b6c7f
27 Nfb74ca1eada04f5f8b8773c129474790
28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034463527
29 https://doi.org/10.1007/pl00002197
30 schema:sdDatePublished 2019-04-10T17:32
31 schema:sdLicense https://scigraph.springernature.com/explorer/license/
32 schema:sdPublisher N76c02b0faf0a4cdd8dfec3cd4c129da7
33 schema:url http://link.springer.com/10.1007%2FPL00002197
34 sgo:license sg:explorer/license/
35 sgo:sdDataset articles
36 rdf:type schema:ScholarlyArticle
37 N006837762bac449392d5929a185e89eb rdf:first sg:person.01201414614.08
38 rdf:rest rdf:nil
39 N00b020aba9944fb4956f4d576188f872 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
40 schema:name Hemostasis
41 rdf:type schema:DefinedTerm
42 N0b7aea24f79f42939fdd8634731a7517 rdf:first sg:person.01200045035.08
43 rdf:rest Nbdc33306ef2841cf8e662f8750895e95
44 N1827d400018643a186912cab8ba2cb79 schema:name dimensions_id
45 schema:value pub.1034463527
46 rdf:type schema:PropertyValue
47 N1cb563fe993649609bb8cf1e14b731ea rdf:first sg:person.012155212702.45
48 rdf:rest N0b7aea24f79f42939fdd8634731a7517
49 N2fc17ba5308a4f9789cff9ea4bd3f401 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
50 schema:name Risk
51 rdf:type schema:DefinedTerm
52 N2fea98feeb8c4b98b037274946017bda schema:name readcube_id
53 schema:value a42bf02dec414fe8b9ea7d573482f8764c2a8fd4d26eebee01294ccb8d0941cd
54 rdf:type schema:PropertyValue
55 N4d90bc788a774ec4a3c59e50943d14f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Genetic Predisposition to Disease
57 rdf:type schema:DefinedTerm
58 N577ef0a3dd2a41aa980715d78f8070f3 schema:issueNumber 4
59 rdf:type schema:PublicationIssue
60 N6df43b0354074b20971ee6f311e3d714 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Polymorphism, Genetic
62 rdf:type schema:DefinedTerm
63 N76c02b0faf0a4cdd8dfec3cd4c129da7 schema:name Springer Nature - SN SciGraph project
64 rdf:type schema:Organization
65 N77bd393eaedc465bbbd62df722c12fc3 rdf:first sg:person.01160622567.30
66 rdf:rest N006837762bac449392d5929a185e89eb
67 N79203acd47764c928e73e7ba4c79b07a schema:name doi
68 schema:value 10.1007/pl00002197
69 rdf:type schema:PropertyValue
70 N83fb552da21c489a978e031afe12c39a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Blood Proteins
72 rdf:type schema:DefinedTerm
73 N8b5605d42e974a12921792442ddf4534 schema:volumeNumber 96
74 rdf:type schema:PublicationVolume
75 Nb608cabaad2749ca972ff211cf4f808f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Blood Coagulation Factors
77 rdf:type schema:DefinedTerm
78 Nb7790667463e4aff9683920f49bb0eeb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Coronary Disease
80 rdf:type schema:DefinedTerm
81 Nbdc33306ef2841cf8e662f8750895e95 rdf:first sg:person.01061540141.95
82 rdf:rest N77bd393eaedc465bbbd62df722c12fc3
83 Nc8f2448e9aec4ddbb8f20295f20b6c7f schema:name pubmed_id
84 schema:value 11370604
85 rdf:type schema:PropertyValue
86 Nd578971950744ab7b56d302f8af784bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Humans
88 rdf:type schema:DefinedTerm
89 Ndf5b12da57be418b981cde9bfe3ca03e rdf:first sg:person.0721160742.85
90 rdf:rest N1cb563fe993649609bb8cf1e14b731ea
91 Nfb74ca1eada04f5f8b8773c129474790 schema:name nlm_unique_id
92 schema:value 8303501
93 rdf:type schema:PropertyValue
94 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
95 schema:name Medical and Health Sciences
96 rdf:type schema:DefinedTerm
97 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
98 schema:name Cardiorespiratory Medicine and Haematology
99 rdf:type schema:DefinedTerm
100 sg:journal.1017977 schema:issn 0723-5003
101 1615-6722
102 schema:name Medizinische Klinik
103 rdf:type schema:Periodical
104 sg:person.01061540141.95 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
105 schema:familyName Preiss
106 schema:givenName Alexandra
107 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061540141.95
108 rdf:type schema:Person
109 sg:person.01160622567.30 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
110 schema:familyName Winkelmann
111 schema:givenName Bernhard Rudolf
112 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160622567.30
113 rdf:type schema:Person
114 sg:person.01200045035.08 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
115 schema:familyName Haubelt
116 schema:givenName Hannelore
117 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200045035.08
118 rdf:type schema:Person
119 sg:person.01201414614.08 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
120 schema:familyName Senges
121 schema:givenName Jochen
122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201414614.08
123 rdf:type schema:Person
124 sg:person.012155212702.45 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
125 schema:familyName Bach
126 schema:givenName Jürgen
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012155212702.45
128 rdf:type schema:Person
129 sg:person.0721160742.85 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
130 schema:familyName Hellstern
131 schema:givenName Peter
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721160742.85
133 rdf:type schema:Person
134 https://www.grid.ac/institutes/grid.413225.3 schema:alternateName Klinikum Ludwigshafen
135 schema:name Herzzentrum, Klinikum Ludwigshafen, DE
136 Institut für Hämostaseologie und Transfusionsmedizin, Klinikum Ludwigshafen, DE
137 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...