Veränderungen der Nierenfunktion älterer Patienten in der perioperativen Phase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-04

AUTHORS

Bernhard Kumle, Joachim Boldt, Stephan Suttner, Swen N. Piper

ABSTRACT

Background: Reduction in organ function is a common problem in the perioperative period of the elderly patient. Especially renal function is often decreased in this situation.Patients and Methods: In a prospective study, we assessed the perioperative changes of renal function in elderly (> 65 years, n = 30) and younger (< 65 years, n = 30) patients without preoperative renal dysfunction who were scheduled for major abdominal surgery. After induction of anesthesia (t0), at the end of surgery (t1), 4 h after surgery (t2), and on the first (t3), second (t4) and third postoperative day (t5), alpha-1-microglobulin, beta-N-acetyl-glucosaminidase, fractional sodium clearance, and creatinine clearance were measured.Results: The creatinine clearance was significantly higher at all time points in the elderly than in the younger patients (p < 0.05). Fractional sodium clearance showed no significant differences between the two groups. At t4 and t5, alpha-1-microglobulin had increased significantly from the baseline value only in the elderly patients. Beta-N-acetyl-glucosaminidase was significantly, elevated compared with the baseline value in the elderly patients and also differed significantly from younger patients during the study period.Conclusion: In elderly patients undergoing major abdominal surgery, short-term alterations in the renal system were observed in the perioperative period. With adequate volume replacement, no relevant disturbances in renal function are to be expected in the elderly surgical patient. More... »

PAGES

202-207

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/pl00002195

DOI

http://dx.doi.org/10.1007/pl00002195

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008475311

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11370601


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