Ontology type: schema:ScholarlyArticle
2000-09
AUTHORSThomas J. Stegmann, Thomas Hoppert, André Schneider, Stefan Gemeinhardt, Michael Köcher, Rainer Ibing, Gerhard Strupp
ABSTRACTCurrently available approaches for treating human coronary heart disease aim to relieve symptoms and the risk of myocardial infarction either by reducing myocardial oxygen demand, preventing further disease progression, restoring coronary blood flow pharmacologically or mechanically, or bypassing the stenotic lesions and obstructed coronary artery segments. Gene therapy, especially using angiogenic growth factors, has emerged recently as a potential new treatment for cardiovascular disease. Following extensive experimental research on angiogenic growth factors, the first clinical studies on patients with coronary heart disease and peripheral vascular lesions have been performed. The polypeptides fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) appear to be particularly effective in initiating neovascularization (neoangiogenesis) in hypoxic or ischemic tissues. The first clinical study on patients with coronary heart disease treated by local intramyocardial injection of FGF-1 showed a 3-fold increase of capillary density mediated by the growth factor. Also, angiogenic growth factor injection intramyocardially as sole therapy for end-stage coronary disease showed an improvement of myocardial perfusion in the target areas as well as a reduction of symptoms and an increase in working capacity. Angiogenic therapy of the human myocardium introduces a new modality of treatment for coronary heart disease in terms of regulation of blood vessel growth. Beyond drug therapy, angioplasty and bypass surgery, this new approach may evolve into a fourth principle of treatment of atherosclerotic cardiovascular disease. More... »
PAGES589-599
http://scigraph.springernature.com/pub.10.1007/pl00001972
DOIhttp://dx.doi.org/10.1007/pl00001972
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1051140665
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/11076317
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Angiogenesis Inducing Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Coronary Circulation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Coronary Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Endothelial Growth Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fibroblast Growth Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphokines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neovascularization, Physiologic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vascular Endothelial Growth Factor A",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vascular Endothelial Growth Factors",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Klinikum Fulda",
"id": "https://www.grid.ac/institutes/grid.419818.d",
"name": [
"Klinik f\u00fcr Thorax-, Herz- und Gef\u00e4\u00dfchirurgie Fulda, Klinikum Fulda, DE"
],
"type": "Organization"
},
"familyName": "Stegmann",
"givenName": "Thomas J.",
"id": "sg:person.01331277460.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331277460.90"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Klinikum Fulda",
"id": "https://www.grid.ac/institutes/grid.419818.d",
"name": [
"Klinik f\u00fcr Thorax-, Herz- und Gef\u00e4\u00dfchirurgie Fulda, Klinikum Fulda, DE"
],
"type": "Organization"
},
"familyName": "Hoppert",
"givenName": "Thomas",
"id": "sg:person.01273160341.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273160341.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Klinikum Fulda",
"id": "https://www.grid.ac/institutes/grid.419818.d",
"name": [
"Klinik f\u00fcr Thorax-, Herz- und Gef\u00e4\u00dfchirurgie Fulda, Klinikum Fulda, DE"
],
"type": "Organization"
},
"familyName": "Schneider",
"givenName": "Andr\u00e9",
"id": "sg:person.0615667441.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615667441.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Klinikum Fulda",
"id": "https://www.grid.ac/institutes/grid.419818.d",
"name": [
"Radiologisches Institut, Klinikum Fulda, DE"
],
"type": "Organization"
},
"familyName": "Gemeinhardt",
"givenName": "Stefan",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Klinikum Fulda",
"id": "https://www.grid.ac/institutes/grid.419818.d",
"name": [
"Radiologisches Institut, Klinikum Fulda, DE"
],
"type": "Organization"
},
"familyName": "K\u00f6cher",
"givenName": "Michael",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Klinikum Fulda",
"id": "https://www.grid.ac/institutes/grid.419818.d",
"name": [
"Medizinische Klinik I, Klinikum Fulda, DE"
],
"type": "Organization"
},
"familyName": "Ibing",
"givenName": "Rainer",
"id": "sg:person.01162573041.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162573041.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Klinikum Fulda",
"id": "https://www.grid.ac/institutes/grid.419818.d",
"name": [
"Medizinische Klinik I, Klinikum Fulda, DE"
],
"type": "Organization"
},
"familyName": "Strupp",
"givenName": "Gerhard",
"id": "sg:person.0601012742.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601012742.84"
],
"type": "Person"
}
],
"datePublished": "2000-09",
"datePublishedReg": "2000-09-01",
"description": "Currently available approaches for treating human coronary heart disease aim to relieve symptoms and the risk of myocardial infarction either by reducing myocardial oxygen demand, preventing further disease progression, restoring coronary blood flow pharmacologically or mechanically, or bypassing the stenotic lesions and obstructed coronary artery segments. Gene therapy, especially using angiogenic growth factors, has emerged recently as a potential new treatment for cardiovascular disease. Following extensive experimental research on angiogenic growth factors, the first clinical studies on patients with coronary heart disease and peripheral vascular lesions have been performed. The polypeptides fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) appear to be particularly effective in initiating neovascularization (neoangiogenesis) in hypoxic or ischemic tissues. The first clinical study on patients with coronary heart disease treated by local intramyocardial injection of FGF-1 showed a 3-fold increase of capillary density mediated by the growth factor. Also, angiogenic growth factor injection intramyocardially as sole therapy for end-stage coronary disease showed an improvement of myocardial perfusion in the target areas as well as a reduction of symptoms and an increase in working capacity. Angiogenic therapy of the human myocardium introduces a new modality of treatment for coronary heart disease in terms of regulation of blood vessel growth. Beyond drug therapy, angioplasty and bypass surgery, this new approach may evolve into a fourth principle of treatment of atherosclerotic cardiovascular disease.",
"genre": "research_article",
"id": "sg:pub.10.1007/pl00001972",
"inLanguage": [
"de"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1087175",
"issn": [
"0340-9937",
"1615-6692"
],
"name": "Herz",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "25"
}
],
"name": "Induktion der myokardialen Neoangiogenese durch humane Wachstumsfaktoren Ein neuer Therapieansatz bei koronarer Herzkrankheit",
"pagination": "589-599",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"f39d7f8c8e33c23af170e246ef4ccb834eb9e42fa65a55ba21fea8bbb19cf6f5"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"11076317"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"7801231"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/pl00001972"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1051140665"
]
}
],
"sameAs": [
"https://doi.org/10.1007/pl00001972",
"https://app.dimensions.ai/details/publication/pub.1051140665"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T17:27",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000491.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/PL00001972"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/pl00001972'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/pl00001972'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/pl00001972'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/pl00001972'
This table displays all metadata directly associated to this object as RDF triples.
159 TRIPLES
20 PREDICATES
41 URIs
33 LITERALS
21 BLANK NODES