ATP-dependent chromatin remodeling activities View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-05

AUTHORS

K. Havas, I. Whitehouse, T. Owen-Hughes

ABSTRACT

Genetic and biochemical approaches have indicated that the packaging of DNA into chromatin can be repressive to transcription. ATP-dependent chromatin remodelling activities can facilitate transcription from chromatin templates. Consistent with this, biochemical assays have shown that the action of ATP-dependent chromatin remodelling activities increase the accessibility of DNA within chromatin templates. However more recent functional studies suggest that many ATP-dependent chromatin remodelling activities can also function as repressors of transcription. Here we review recent advances to our understanding of the biological function of these complexes. We then consider some of the mechanisms by which ATP-dependent chromatin remodelling activities together with other forms of chromatin remodelling or modifying enzymes may act to regulate genomic accessibility either positively or negatively. More... »

PAGES

673-682

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/pl00000891

DOI

http://dx.doi.org/10.1007/pl00000891

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028094447

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11437229


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