TreFoil Factor 1 (TFF1/pS2) Deficiency Activates the Unfolded Protein Response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-05

AUTHORS

Luis-Fernando Torres, Sherif M. Karam, Corinne Wendling, Marie-Pierre Chenard, David Kershenobich, Catherine Tomasetto, Marie-Christine Rio

ABSTRACT

BACKGROUND: The trefoil factor 1 (TFF1/pS2) is a secreted gastrointestinal peptide that is often altered or lost in human gastric cancers. Consistently, mouse TFF1 deficiency leads to antropyloric tumors. MATERIALS AND METHODS: To investigate the gene expression alterations in response to the lack of TFF1, we performed differential expression analyses of TFF1 null antropyloric tumors using an array containing 588 cDNAs. RESULTS: Using total and enriched probes, 22 genes were found to be up-regulated. The identification of the genes for endoplasmic reticulum (ER)-resident GRP78, ERp72, and p58IPK proteins connected TFF1 deficiency to the unfolded protein response (UPR). Accordingly, CHOP10, a transcription factor induced early in response to ER stress, and the pleiotropic Clusterin, involved in protein folding, were also overexpressed. Northern blot analyses of 8 weeks and 1 year TFF1 null tumors confirmed that GRP78, ERp72, p58IPK, CHOP10, and Clusterin overexpression is a common and permanent feature shared by all TFF1 null antropyloric tumors. Finally, consistent with UPR, ultrastructural analyses showed that tumor rough ER was enlarged and contained dense material, supporting the hypothesis that TFF1 deficiency leads to the accumulation of misfolded proteins in the ER. CONCLUSION: Together, our data provide the first evidence of a relationship between a member of the TFF family and the ER machinery. Whereas to date TFF1 is believed to act as an extracellular molecule, our results suggest a possible additional function for TFF1 in protein folding and/or secretion. More... »

PAGES

273-282

References to SciGraph publications

  • 1992-01. Protein folding in the cell in NATURE
  • 1997-12. Trefoil peptides: from structure to function in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2001-12. Milestones in cell division : To cycle or not to cycle: a critical decision in cancer in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf03402153

    DOI

    http://dx.doi.org/10.1007/bf03402153

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1075169302

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12359958


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA, Complementary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endoplasmic Reticulum, Rough", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Growth Substances", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Peptides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Folding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pyloric Antrum", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Trefoil Factor-1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Up-Regulation", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n", 
              "id": "https://www.grid.ac/institutes/grid.416850.e", 
              "name": [
                "Gastroenterology Department, Instituto Nacional de Ciencias M\u00e9dicas y de la Nutricion \u201cSalvador Zubiran\u201d (INCMNSZ), Distrito Federal M\u00e9xico, M\u00e9xico"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Torres", 
            "givenName": "Luis-Fernando", 
            "id": "sg:person.01336110530.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336110530.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "United Arab Emirates University", 
              "id": "https://www.grid.ac/institutes/grid.43519.3a", 
              "name": [
                "Department of Anatomy, Faculty of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karam", 
            "givenName": "Sherif M.", 
            "id": "sg:person.0764107174.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764107174.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), C.U. de Strasbourg, BP 10142, 67404, Illkirch Cedex, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wendling", 
            "givenName": "Corinne", 
            "id": "sg:person.01115050057.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115050057.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), C.U. de Strasbourg, BP 10142, 67404, Illkirch Cedex, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chenard", 
            "givenName": "Marie-Pierre", 
            "id": "sg:person.0640156105.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640156105.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n", 
              "id": "https://www.grid.ac/institutes/grid.416850.e", 
              "name": [
                "Gastroenterology Department, Instituto Nacional de Ciencias M\u00e9dicas y de la Nutricion \u201cSalvador Zubiran\u201d (INCMNSZ), Distrito Federal M\u00e9xico, M\u00e9xico"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kershenobich", 
            "givenName": "David", 
            "id": "sg:person.074207567.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074207567.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), C.U. de Strasbourg, BP 10142, 67404, Illkirch Cedex, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tomasetto", 
            "givenName": "Catherine", 
            "id": "sg:person.01101354447.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101354447.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), C.U. de Strasbourg, BP 10142, 67404, Illkirch Cedex, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rio", 
            "givenName": "Marie-Christine", 
            "id": "sg:person.0662512020.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662512020.41"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s0016-5085(99)70010-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001902917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-419x(98)00016-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002447282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.15.7690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004651427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.16.8.4273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005154708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(200003)190:4<437::aid-path547>3.0.co;2-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010715071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00623-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011908543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.43.2.240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012855914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0016-5085(00)70415-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013178942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0016-5085(00)70415-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013178942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/gast.1996.v110.pm8566596", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013984430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.150.1.77", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014628101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(99)01534-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017883984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.46.3.312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019426323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.66.1.751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019662237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.44.5.636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019867306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.2.799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020877037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.7.4757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021043832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2264(199704)18:4<318::aid-gcc12>3.0.co;2-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022659568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.2000.3176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023709472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90518-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023856173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.20.13.4680-4690.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024355098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s000180050108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026668301", 
              "https://doi.org/10.1007/s000180050108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35106065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029289076", 
              "https://doi.org/10.1038/35106065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35106065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029289076", 
              "https://doi.org/10.1038/35106065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-0115(00)00110-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029615294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/gast.2000.16483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030036284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.10.1211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032297242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(76)90139-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032741297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/geno.1995.1163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034931731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/355033a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035186983", 
              "https://doi.org/10.1038/355033a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-5521(96)90178-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040556039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199907)188:3<312::aid-path360>3.0.co;2-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041601738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.47.6.792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042641720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m010534200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042831058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb200108056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045429471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/geno.1996.4511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046658592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(00)00248-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046905022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.5.2137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047478477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-3835(99)00349-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047753249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(99)00033-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049805296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci11476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050757426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-1119(01)00380-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051104961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(00)00219-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051509300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.00-0355com", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052525544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.16.8584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052595890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199805)185:1<38::aid-path58>3.0.co;2-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052904487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs0880401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056728262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs0880401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056728262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.274.5285.259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062554404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.274.5285.262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062554405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3041593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062585332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/a426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070917209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.14670/hh-16.319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074762177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082434634", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(93)90830-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082798997"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2002-05", 
        "datePublishedReg": "2002-05-01", 
        "description": "BACKGROUND: The trefoil factor 1 (TFF1/pS2) is a secreted gastrointestinal peptide that is often altered or lost in human gastric cancers. Consistently, mouse TFF1 deficiency leads to antropyloric tumors.\nMATERIALS AND METHODS: To investigate the gene expression alterations in response to the lack of TFF1, we performed differential expression analyses of TFF1 null antropyloric tumors using an array containing 588 cDNAs.\nRESULTS: Using total and enriched probes, 22 genes were found to be up-regulated. The identification of the genes for endoplasmic reticulum (ER)-resident GRP78, ERp72, and p58IPK proteins connected TFF1 deficiency to the unfolded protein response (UPR). Accordingly, CHOP10, a transcription factor induced early in response to ER stress, and the pleiotropic Clusterin, involved in protein folding, were also overexpressed. Northern blot analyses of 8 weeks and 1 year TFF1 null tumors confirmed that GRP78, ERp72, p58IPK, CHOP10, and Clusterin overexpression is a common and permanent feature shared by all TFF1 null antropyloric tumors. Finally, consistent with UPR, ultrastructural analyses showed that tumor rough ER was enlarged and contained dense material, supporting the hypothesis that TFF1 deficiency leads to the accumulation of misfolded proteins in the ER.\nCONCLUSION: Together, our data provide the first evidence of a relationship between a member of the TFF family and the ER machinery. Whereas to date TFF1 is believed to act as an extracellular molecule, our results suggest a possible additional function for TFF1 in protein folding and/or secretion.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/bf03402153", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1113628", 
            "issn": [
              "1076-1551", 
              "1528-3658"
            ], 
            "name": "Molecular Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "TreFoil Factor 1 (TFF1/pS2) Deficiency Activates the Unfolded Protein Response", 
        "pagination": "273-282", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b3a44bf6844a9c85c648d76ad3f7083a9cb0248861a5bcd200c42d68bf3c2600"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "12359958"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9501023"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf03402153"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1075169302"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf03402153", 
          "https://app.dimensions.ai/details/publication/pub.1075169302"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T23:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000525.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2FBF03402153"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf03402153'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf03402153'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf03402153'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf03402153'


     

    This table displays all metadata directly associated to this object as RDF triples.

    332 TRIPLES      21 PREDICATES      94 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf03402153 schema:about N1129aa677a0e4d3984d92f8a18f26bec
    2 N160eeb285e6d4d97a0a102d3aa801912
    3 N3526cbc1981946d5a7d4d06c6e8e96cc
    4 N5ac3966f27b44c5db533d6325764da42
    5 N618dfbc845254377bc7d337942504970
    6 N701902fa1ae04e8593ffe05bcf6e4f31
    7 N88bed7c214fd4c1991ae4a4a577baaf8
    8 Nbceeeba54327489aa498977e22a6a9c8
    9 Ncf79f974df544d7cb71cbefe1d5ced27
    10 Nde2cb3d22620430a9a49c848d4c724d4
    11 Nf37c769e395e406e9403ffa134b1a216
    12 Nf5dbee7d73b24870b11fff42a010a18b
    13 Nf5fa603ef88241d28f36d42719c13038
    14 anzsrc-for:06
    15 anzsrc-for:0601
    16 schema:author N0a7219d6cddc4c108e0a0091cf8bbbbf
    17 schema:citation sg:pub.10.1007/s000180050108
    18 sg:pub.10.1038/35106065
    19 sg:pub.10.1038/355033a0
    20 https://app.dimensions.ai/details/publication/pub.1082434634
    21 https://doi.org/10.1002/(sici)1096-9896(199805)185:1<38::aid-path58>3.0.co;2-t
    22 https://doi.org/10.1002/(sici)1096-9896(199907)188:3<312::aid-path360>3.0.co;2-p
    23 https://doi.org/10.1002/(sici)1096-9896(200003)190:4<437::aid-path547>3.0.co;2-1
    24 https://doi.org/10.1002/(sici)1098-2264(199704)18:4<318::aid-gcc12>3.0.co;2-c
    25 https://doi.org/10.1006/bbrc.2000.3176
    26 https://doi.org/10.1006/geno.1995.1163
    27 https://doi.org/10.1006/geno.1996.4511
    28 https://doi.org/10.1016/0016-5085(93)90830-6
    29 https://doi.org/10.1016/0092-8674(76)90139-2
    30 https://doi.org/10.1016/0092-8674(94)90518-5
    31 https://doi.org/10.1016/s0016-5085(00)70415-x
    32 https://doi.org/10.1016/s0016-5085(99)70010-7
    33 https://doi.org/10.1016/s0092-8674(01)00623-7
    34 https://doi.org/10.1016/s0167-0115(00)00110-5
    35 https://doi.org/10.1016/s0304-3835(99)00349-3
    36 https://doi.org/10.1016/s0304-419x(98)00016-x
    37 https://doi.org/10.1016/s0378-1119(01)00380-8
    38 https://doi.org/10.1016/s0955-0674(00)00219-2
    39 https://doi.org/10.1016/s0955-0674(00)00248-9
    40 https://doi.org/10.1016/s0959-437x(99)00033-7
    41 https://doi.org/10.1016/s0968-0004(99)01534-0
    42 https://doi.org/10.1016/s1074-5521(96)90178-7
    43 https://doi.org/10.1042/cs0880401
    44 https://doi.org/10.1053/gast.1996.v110.pm8566596
    45 https://doi.org/10.1053/gast.2000.16483
    46 https://doi.org/10.1073/pnas.93.15.7690
    47 https://doi.org/10.1073/pnas.93.16.8584
    48 https://doi.org/10.1073/pnas.93.5.2137
    49 https://doi.org/10.1073/pnas.97.2.799
    50 https://doi.org/10.1074/jbc.m010534200
    51 https://doi.org/10.1083/jcb.150.1.77
    52 https://doi.org/10.1083/jcb200108056
    53 https://doi.org/10.1096/fj.00-0355com
    54 https://doi.org/10.1101/gad.13.10.1211
    55 https://doi.org/10.1126/science.274.5285.259
    56 https://doi.org/10.1126/science.274.5285.262
    57 https://doi.org/10.1126/science.3041593
    58 https://doi.org/10.1128/mcb.16.8.4273
    59 https://doi.org/10.1128/mcb.19.7.4757
    60 https://doi.org/10.1128/mcb.20.13.4680-4690.2000
    61 https://doi.org/10.1136/gut.43.2.240
    62 https://doi.org/10.1136/gut.44.5.636
    63 https://doi.org/10.1136/gut.46.3.312
    64 https://doi.org/10.1136/gut.47.6.792
    65 https://doi.org/10.1146/annurev.biochem.66.1.751
    66 https://doi.org/10.1172/jci11476
    67 https://doi.org/10.14670/hh-16.319
    68 https://doi.org/10.2741/a426
    69 schema:datePublished 2002-05
    70 schema:datePublishedReg 2002-05-01
    71 schema:description BACKGROUND: The trefoil factor 1 (TFF1/pS2) is a secreted gastrointestinal peptide that is often altered or lost in human gastric cancers. Consistently, mouse TFF1 deficiency leads to antropyloric tumors. MATERIALS AND METHODS: To investigate the gene expression alterations in response to the lack of TFF1, we performed differential expression analyses of TFF1 null antropyloric tumors using an array containing 588 cDNAs. RESULTS: Using total and enriched probes, 22 genes were found to be up-regulated. The identification of the genes for endoplasmic reticulum (ER)-resident GRP78, ERp72, and p58IPK proteins connected TFF1 deficiency to the unfolded protein response (UPR). Accordingly, CHOP10, a transcription factor induced early in response to ER stress, and the pleiotropic Clusterin, involved in protein folding, were also overexpressed. Northern blot analyses of 8 weeks and 1 year TFF1 null tumors confirmed that GRP78, ERp72, p58IPK, CHOP10, and Clusterin overexpression is a common and permanent feature shared by all TFF1 null antropyloric tumors. Finally, consistent with UPR, ultrastructural analyses showed that tumor rough ER was enlarged and contained dense material, supporting the hypothesis that TFF1 deficiency leads to the accumulation of misfolded proteins in the ER. CONCLUSION: Together, our data provide the first evidence of a relationship between a member of the TFF family and the ER machinery. Whereas to date TFF1 is believed to act as an extracellular molecule, our results suggest a possible additional function for TFF1 in protein folding and/or secretion.
    72 schema:genre research_article
    73 schema:inLanguage en
    74 schema:isAccessibleForFree true
    75 schema:isPartOf N66406799f5ed4038be1c39071f68e499
    76 Nba4167ea731647999b5a2411291caf7e
    77 sg:journal.1113628
    78 schema:name TreFoil Factor 1 (TFF1/pS2) Deficiency Activates the Unfolded Protein Response
    79 schema:pagination 273-282
    80 schema:productId N4bc9682dd4f44ea8b2cf69060ced437b
    81 Nb0fc60507d514a9c8b61956b92464a7a
    82 Nb3ff9fec61aa4fcda39cfacb043d462e
    83 Ncc69c044fca64b18a08525288f880a9b
    84 Nedda03878d74460da5a60e8c969f876a
    85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075169302
    86 https://doi.org/10.1007/bf03402153
    87 schema:sdDatePublished 2019-04-10T23:28
    88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    89 schema:sdPublisher N87368b2d315f4f12a9ea8e35702a64b0
    90 schema:url http://link.springer.com/10.1007%2FBF03402153
    91 sgo:license sg:explorer/license/
    92 sgo:sdDataset articles
    93 rdf:type schema:ScholarlyArticle
    94 N02cdc64f73f747aca18eacf257d92b15 schema:name Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), C.U. de Strasbourg, BP 10142, 67404, Illkirch Cedex, France
    95 rdf:type schema:Organization
    96 N0a7219d6cddc4c108e0a0091cf8bbbbf rdf:first sg:person.01336110530.33
    97 rdf:rest Ncae800d30ba74178a98c850776b5a9db
    98 N1129aa677a0e4d3984d92f8a18f26bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Pyloric Antrum
    100 rdf:type schema:DefinedTerm
    101 N160eeb285e6d4d97a0a102d3aa801912 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Tumor Suppressor Proteins
    103 rdf:type schema:DefinedTerm
    104 N1e65ea87121d4ab2b428114b1e888ebf rdf:first sg:person.01115050057.00
    105 rdf:rest N3d957f5cf1ab4d16a2b387cc6266d450
    106 N3526cbc1981946d5a7d4d06c6e8e96cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Mice
    108 rdf:type schema:DefinedTerm
    109 N3d957f5cf1ab4d16a2b387cc6266d450 rdf:first sg:person.0640156105.33
    110 rdf:rest Ne6b93fabb6d04502a13485aed6b93ac6
    111 N4bc9682dd4f44ea8b2cf69060ced437b schema:name pubmed_id
    112 schema:value 12359958
    113 rdf:type schema:PropertyValue
    114 N5ac3966f27b44c5db533d6325764da42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name DNA, Complementary
    116 rdf:type schema:DefinedTerm
    117 N618dfbc845254377bc7d337942504970 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Endoplasmic Reticulum, Rough
    119 rdf:type schema:DefinedTerm
    120 N66406799f5ed4038be1c39071f68e499 schema:issueNumber 5
    121 rdf:type schema:PublicationIssue
    122 N701902fa1ae04e8593ffe05bcf6e4f31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Peptides
    124 rdf:type schema:DefinedTerm
    125 N87368b2d315f4f12a9ea8e35702a64b0 schema:name Springer Nature - SN SciGraph project
    126 rdf:type schema:Organization
    127 N88bed7c214fd4c1991ae4a4a577baaf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Neoplasms
    129 rdf:type schema:DefinedTerm
    130 N994ab8d996cd4c7b9af2adb7bedf0d9a schema:name Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), C.U. de Strasbourg, BP 10142, 67404, Illkirch Cedex, France
    131 rdf:type schema:Organization
    132 Na29ed7ef074f4225ab196cf78550a351 schema:name Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), C.U. de Strasbourg, BP 10142, 67404, Illkirch Cedex, France
    133 rdf:type schema:Organization
    134 Nac4dbf46e09d4e26b22c470658914fc2 rdf:first sg:person.01101354447.59
    135 rdf:rest Nc82a4030cd8a4a5e9d6623dbf472b996
    136 Nb0fc60507d514a9c8b61956b92464a7a schema:name readcube_id
    137 schema:value b3a44bf6844a9c85c648d76ad3f7083a9cb0248861a5bcd200c42d68bf3c2600
    138 rdf:type schema:PropertyValue
    139 Nb3ff9fec61aa4fcda39cfacb043d462e schema:name dimensions_id
    140 schema:value pub.1075169302
    141 rdf:type schema:PropertyValue
    142 Nb980d41690b24f0dbc0526b37f227155 schema:name Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), C.U. de Strasbourg, BP 10142, 67404, Illkirch Cedex, France
    143 rdf:type schema:Organization
    144 Nba4167ea731647999b5a2411291caf7e schema:volumeNumber 8
    145 rdf:type schema:PublicationVolume
    146 Nbceeeba54327489aa498977e22a6a9c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Protein Folding
    148 rdf:type schema:DefinedTerm
    149 Nc82a4030cd8a4a5e9d6623dbf472b996 rdf:first sg:person.0662512020.41
    150 rdf:rest rdf:nil
    151 Ncae800d30ba74178a98c850776b5a9db rdf:first sg:person.0764107174.78
    152 rdf:rest N1e65ea87121d4ab2b428114b1e888ebf
    153 Ncc69c044fca64b18a08525288f880a9b schema:name doi
    154 schema:value 10.1007/bf03402153
    155 rdf:type schema:PropertyValue
    156 Ncf79f974df544d7cb71cbefe1d5ced27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Growth Substances
    158 rdf:type schema:DefinedTerm
    159 Nde2cb3d22620430a9a49c848d4c724d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Trefoil Factor-1
    161 rdf:type schema:DefinedTerm
    162 Ne6b93fabb6d04502a13485aed6b93ac6 rdf:first sg:person.074207567.35
    163 rdf:rest Nac4dbf46e09d4e26b22c470658914fc2
    164 Nedda03878d74460da5a60e8c969f876a schema:name nlm_unique_id
    165 schema:value 9501023
    166 rdf:type schema:PropertyValue
    167 Nf37c769e395e406e9403ffa134b1a216 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Proteins
    169 rdf:type schema:DefinedTerm
    170 Nf5dbee7d73b24870b11fff42a010a18b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Up-Regulation
    172 rdf:type schema:DefinedTerm
    173 Nf5fa603ef88241d28f36d42719c13038 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Animals
    175 rdf:type schema:DefinedTerm
    176 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Biological Sciences
    178 rdf:type schema:DefinedTerm
    179 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    180 schema:name Biochemistry and Cell Biology
    181 rdf:type schema:DefinedTerm
    182 sg:journal.1113628 schema:issn 1076-1551
    183 1528-3658
    184 schema:name Molecular Medicine
    185 rdf:type schema:Periodical
    186 sg:person.01101354447.59 schema:affiliation Nb980d41690b24f0dbc0526b37f227155
    187 schema:familyName Tomasetto
    188 schema:givenName Catherine
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101354447.59
    190 rdf:type schema:Person
    191 sg:person.01115050057.00 schema:affiliation Na29ed7ef074f4225ab196cf78550a351
    192 schema:familyName Wendling
    193 schema:givenName Corinne
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115050057.00
    195 rdf:type schema:Person
    196 sg:person.01336110530.33 schema:affiliation https://www.grid.ac/institutes/grid.416850.e
    197 schema:familyName Torres
    198 schema:givenName Luis-Fernando
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336110530.33
    200 rdf:type schema:Person
    201 sg:person.0640156105.33 schema:affiliation N02cdc64f73f747aca18eacf257d92b15
    202 schema:familyName Chenard
    203 schema:givenName Marie-Pierre
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640156105.33
    205 rdf:type schema:Person
    206 sg:person.0662512020.41 schema:affiliation N994ab8d996cd4c7b9af2adb7bedf0d9a
    207 schema:familyName Rio
    208 schema:givenName Marie-Christine
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662512020.41
    210 rdf:type schema:Person
    211 sg:person.074207567.35 schema:affiliation https://www.grid.ac/institutes/grid.416850.e
    212 schema:familyName Kershenobich
    213 schema:givenName David
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074207567.35
    215 rdf:type schema:Person
    216 sg:person.0764107174.78 schema:affiliation https://www.grid.ac/institutes/grid.43519.3a
    217 schema:familyName Karam
    218 schema:givenName Sherif M.
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764107174.78
    220 rdf:type schema:Person
    221 sg:pub.10.1007/s000180050108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026668301
    222 https://doi.org/10.1007/s000180050108
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/35106065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029289076
    225 https://doi.org/10.1038/35106065
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/355033a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035186983
    228 https://doi.org/10.1038/355033a0
    229 rdf:type schema:CreativeWork
    230 https://app.dimensions.ai/details/publication/pub.1082434634 schema:CreativeWork
    231 https://doi.org/10.1002/(sici)1096-9896(199805)185:1<38::aid-path58>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1052904487
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1002/(sici)1096-9896(199907)188:3<312::aid-path360>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1041601738
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1002/(sici)1096-9896(200003)190:4<437::aid-path547>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010715071
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1002/(sici)1098-2264(199704)18:4<318::aid-gcc12>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1022659568
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1006/bbrc.2000.3176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023709472
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1006/geno.1995.1163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034931731
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1006/geno.1996.4511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046658592
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/0016-5085(93)90830-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082798997
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/0092-8674(76)90139-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032741297
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/0092-8674(94)90518-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023856173
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/s0016-5085(00)70415-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013178942
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/s0016-5085(99)70010-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001902917
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/s0092-8674(01)00623-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011908543
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/s0167-0115(00)00110-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029615294
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/s0304-3835(99)00349-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047753249
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/s0304-419x(98)00016-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002447282
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/s0378-1119(01)00380-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051104961
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/s0955-0674(00)00219-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051509300
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/s0955-0674(00)00248-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046905022
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/s0959-437x(99)00033-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049805296
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/s0968-0004(99)01534-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017883984
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/s1074-5521(96)90178-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040556039
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1042/cs0880401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056728262
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1053/gast.1996.v110.pm8566596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013984430
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1053/gast.2000.16483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030036284
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1073/pnas.93.15.7690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004651427
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1073/pnas.93.16.8584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052595890
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1073/pnas.93.5.2137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047478477
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1073/pnas.97.2.799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020877037
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1074/jbc.m010534200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042831058
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1083/jcb.150.1.77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014628101
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1083/jcb200108056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045429471
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1096/fj.00-0355com schema:sameAs https://app.dimensions.ai/details/publication/pub.1052525544
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1101/gad.13.10.1211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032297242
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1126/science.274.5285.259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554404
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1126/science.274.5285.262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554405
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1126/science.3041593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062585332
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1128/mcb.16.8.4273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005154708
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1128/mcb.19.7.4757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021043832
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1128/mcb.20.13.4680-4690.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024355098
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1136/gut.43.2.240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012855914
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1136/gut.44.5.636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019867306
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1136/gut.46.3.312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019426323
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1136/gut.47.6.792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042641720
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1146/annurev.biochem.66.1.751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019662237
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1172/jci11476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050757426
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.14670/hh-16.319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074762177
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.2741/a426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070917209
    326 rdf:type schema:CreativeWork
    327 https://www.grid.ac/institutes/grid.416850.e schema:alternateName Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
    328 schema:name Gastroenterology Department, Instituto Nacional de Ciencias Médicas y de la Nutricion “Salvador Zubiran” (INCMNSZ), Distrito Federal México, México
    329 rdf:type schema:Organization
    330 https://www.grid.ac/institutes/grid.43519.3a schema:alternateName United Arab Emirates University
    331 schema:name Department of Anatomy, Faculty of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    332 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...