Ubiquitous Induction of p53 in Tumor Cells by Antisense Inhibition of MDM2 Expression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-01-01

AUTHORS

Lihong Chen, Wenge Lu, Sudhir Agrawal, Wenqiang Zhou, Ruiwen Zhang, Jiandong Chen

ABSTRACT

BackgroundThe MDM2 oncogene functions as a negative feedback regulator of the p53 tumor suppressor. Abnormal expression of MDM2 in tumors may attenuate the p53-mediated growth arrest and apoptosis response, resulting in increased cell proliferation and resistance to chemotherapy.Materials and MethodsWe have developed phosphorothioate antisense oligodeoxynucleotides optimized for inhibition of MDM2 expression and investigated the role of MDM2 in a large panel of tumor cell lines.ResultsInhibition of MDM2 expression in 15 tumor types containing wild-type p53 results in a significant induction of nuclear p53 accumulation. The increase in p53 level is due to prolonged half-life and is associated with an increase in p53 transcriptional activity, growth inhibition, or apoptosis. Inhibition of MDM2 expression is also sufficient to induce nuclear p53 accumulation in several cell lines with cytoplasmic p53.ConclusionsThe MDM2 negative feedback loop is important for maintenance of p53 at a low level by promoting p53 degradation. Nuclear export and degradation by MDM2 may contribute to the p53 nuclear exclusion phenotype. Inhibition of MDM2 expression can effectively activate p53 in most tumor types, including those without MDM2 overexpression, and may have broad anti-tumor potential. More... »

PAGES

21-34

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03402136

DOI

http://dx.doi.org/10.1007/bf03402136

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1074262577

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10072445


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Choriocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feedback", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligodeoxyribonucleotides, Antisense", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-mdm2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uterine Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, Stanley S. Scott Cancer Center, Louisiana State University Medical Center, 1901 Perdido Street, 70112, New Orleans, LA, USA", 
          "id": "http://www.grid.ac/institutes/grid.470125.5", 
          "name": [
            "Department of Microbiology, Stanley S. Scott Cancer Center, Louisiana State University Medical Center, 1901 Perdido Street, 70112, New Orleans, LA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Lihong", 
        "id": "sg:person.012105024377.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012105024377.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, Stanley S. Scott Cancer Center, Louisiana State University Medical Center, 1901 Perdido Street, 70112, New Orleans, LA, USA", 
          "id": "http://www.grid.ac/institutes/grid.470125.5", 
          "name": [
            "Department of Microbiology, Stanley S. Scott Cancer Center, Louisiana State University Medical Center, 1901 Perdido Street, 70112, New Orleans, LA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Wenge", 
        "id": "sg:person.0774075322.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774075322.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hybridon, Inc., Cambridge, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.452508.e", 
          "name": [
            "Hybridon, Inc., Cambridge, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agrawal", 
        "givenName": "Sudhir", 
        "id": "sg:person.01124454740.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124454740.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hybridon, Inc., Cambridge, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.452508.e", 
          "name": [
            "Hybridon, Inc., Cambridge, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Wenqiang", 
        "id": "sg:person.0711710767.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711710767.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Ruiwen", 
        "id": "sg:person.011364334577.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011364334577.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, Stanley S. Scott Cancer Center, Louisiana State University Medical Center, 1901 Perdido Street, 70112, New Orleans, LA, USA", 
          "id": "http://www.grid.ac/institutes/grid.470125.5", 
          "name": [
            "Department of Microbiology, Stanley S. Scott Cancer Center, Louisiana State University Medical Center, 1901 Perdido Street, 70112, New Orleans, LA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Jiandong", 
        "id": "sg:person.01227525617.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227525617.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/378206a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007191650", 
          "https://doi.org/10.1038/378206a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/387296a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004301257", 
          "https://doi.org/10.1038/387296a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014670955", 
          "https://doi.org/10.1038/sj.onc.1201459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362847a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032575717", 
          "https://doi.org/10.1038/362847a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/358080a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008811763", 
          "https://doi.org/10.1038/358080a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/387299a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037935695", 
          "https://doi.org/10.1038/387299a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378203a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015059358", 
          "https://doi.org/10.1038/378203a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053233454", 
          "https://doi.org/10.1038/sj.onc.1201453"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-01-01", 
    "datePublishedReg": "1999-01-01", 
    "description": "BackgroundThe MDM2 oncogene functions as a negative feedback regulator of the p53 tumor suppressor. Abnormal expression of MDM2 in tumors may attenuate the p53-mediated growth arrest and apoptosis response, resulting in increased cell proliferation and resistance to chemotherapy.Materials and MethodsWe have developed phosphorothioate antisense oligodeoxynucleotides optimized for inhibition of MDM2 expression and investigated the role of MDM2 in a large panel of tumor cell lines.ResultsInhibition of MDM2 expression in 15 tumor types containing wild-type p53 results in a significant induction of nuclear p53 accumulation. The increase in p53 level is due to prolonged half-life and is associated with an increase in p53 transcriptional activity, growth inhibition, or apoptosis. Inhibition of MDM2 expression is also sufficient to induce nuclear p53 accumulation in several cell lines with cytoplasmic p53.ConclusionsThe MDM2 negative feedback loop is important for maintenance of p53 at a low level by promoting p53 degradation. Nuclear export and degradation by MDM2 may contribute to the p53 nuclear exclusion phenotype. Inhibition of MDM2 expression can effectively activate p53 in most tumor types, including those without MDM2 overexpression, and may have broad anti-tumor potential.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf03402136", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1113628", 
        "issn": [
          "1076-1551", 
          "1528-3658"
        ], 
        "name": "Molecular Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "p53-mediated growth arrest", 
      "wild-type p53 results", 
      "p53 tumor suppressor", 
      "MDM2 expression", 
      "cell lines", 
      "nuclear p53 accumulation", 
      "p53 transcriptional activity", 
      "negative feedback regulator", 
      "negative feedback loop", 
      "role of MDM2", 
      "nuclear export", 
      "oncogene function", 
      "tumor suppressor", 
      "growth arrest", 
      "p53 accumulation", 
      "transcriptional activity", 
      "apoptosis response", 
      "tumor types", 
      "ubiquitous induction", 
      "tumor cell lines", 
      "p53 results", 
      "p53 degradation", 
      "antisense inhibition", 
      "feedback regulator", 
      "cell proliferation", 
      "p53 levels", 
      "most tumor types", 
      "anti-tumor potential", 
      "abnormal expression", 
      "significant induction", 
      "growth inhibition", 
      "expression", 
      "MDM2", 
      "phosphorothioate antisense oligodeoxynucleotides", 
      "p53", 
      "feedback loop", 
      "MDM2 overexpression", 
      "tumor cells", 
      "antisense oligodeoxynucleotides", 
      "inhibition", 
      "suppressor", 
      "large panel", 
      "induction", 
      "accumulation", 
      "regulator", 
      "ResultsInhibition", 
      "overexpression", 
      "apoptosis", 
      "degradation", 
      "phenotype", 
      "lines", 
      "low levels", 
      "arrest", 
      "proliferation", 
      "chemotherapy", 
      "cells", 
      "tumors", 
      "MethodsWe", 
      "maintenance", 
      "export", 
      "oligodeoxynucleotides", 
      "role", 
      "levels", 
      "increase", 
      "activity", 
      "function", 
      "response", 
      "resistance", 
      "types", 
      "loop", 
      "panel", 
      "potential", 
      "results", 
      "materials"
    ], 
    "name": "Ubiquitous Induction of p53 in Tumor Cells by Antisense Inhibition of MDM2 Expression", 
    "pagination": "21-34", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1074262577"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf03402136"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10072445"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf03402136", 
      "https://app.dimensions.ai/details/publication/pub.1074262577"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_343.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf03402136"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf03402136'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf03402136'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf03402136'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf03402136'


 

This table displays all metadata directly associated to this object as RDF triples.

288 TRIPLES      21 PREDICATES      127 URIs      111 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf03402136 schema:about N0dd966fc53324798b03715ae895e8cbb
2 N26e852192dae4c429ed9cc380828f71b
3 N27a3325d4b1648f99f65530d2edd873e
4 N316e93e8b4be482e8e97f52a42107f3a
5 N47bb66646b5f417985b19270fbe4c2c7
6 N51b99a84dc2a42e3aeb8c8dfeefe6c60
7 N52270872fb724b3b864183d251168e36
8 N586dfdedf8cc46c8909b869f7cfbbdb6
9 N610e6a9d4ec74036b56df68d541cf91e
10 N725a33a29e584dfa85c12e467266749d
11 N73fda4694c91457a9f6f4223787dd228
12 Nb2b028d298cb4ca3910c63a1d611458d
13 Nb4fc2f83485a4775967a23339d62f8ff
14 Nc822b3a8285048d59ffcc0c1aabc7dbd
15 Nd64d9e1fc01548a4975a12c386bcb77b
16 Nda3f841112e24e1b9541c059f1fcc21d
17 Nddee424f6b5e441dac4db168b42790c9
18 Nef851749f6e64bafabb9e83321ddc495
19 Nef897d63ff3146c699d2c5e46f4050eb
20 Nf7df09e78aed4546be214de0ed82d420
21 anzsrc-for:06
22 anzsrc-for:0601
23 schema:author Nb7c6044baa6d4d9c9c474dfc6d3a257e
24 schema:citation sg:pub.10.1038/358080a0
25 sg:pub.10.1038/362847a0
26 sg:pub.10.1038/378203a0
27 sg:pub.10.1038/378206a0
28 sg:pub.10.1038/387296a0
29 sg:pub.10.1038/387299a0
30 sg:pub.10.1038/sj.onc.1201453
31 sg:pub.10.1038/sj.onc.1201459
32 schema:datePublished 1999-01-01
33 schema:datePublishedReg 1999-01-01
34 schema:description BackgroundThe MDM2 oncogene functions as a negative feedback regulator of the p53 tumor suppressor. Abnormal expression of MDM2 in tumors may attenuate the p53-mediated growth arrest and apoptosis response, resulting in increased cell proliferation and resistance to chemotherapy.Materials and MethodsWe have developed phosphorothioate antisense oligodeoxynucleotides optimized for inhibition of MDM2 expression and investigated the role of MDM2 in a large panel of tumor cell lines.ResultsInhibition of MDM2 expression in 15 tumor types containing wild-type p53 results in a significant induction of nuclear p53 accumulation. The increase in p53 level is due to prolonged half-life and is associated with an increase in p53 transcriptional activity, growth inhibition, or apoptosis. Inhibition of MDM2 expression is also sufficient to induce nuclear p53 accumulation in several cell lines with cytoplasmic p53.ConclusionsThe MDM2 negative feedback loop is important for maintenance of p53 at a low level by promoting p53 degradation. Nuclear export and degradation by MDM2 may contribute to the p53 nuclear exclusion phenotype. Inhibition of MDM2 expression can effectively activate p53 in most tumor types, including those without MDM2 overexpression, and may have broad anti-tumor potential.
35 schema:genre article
36 schema:isAccessibleForFree true
37 schema:isPartOf Ne48e8ee25196487b81d16039d6608d9b
38 Nf8a74ac9b5d545bd85598fba7f41e932
39 sg:journal.1113628
40 schema:keywords MDM2
41 MDM2 expression
42 MDM2 overexpression
43 MethodsWe
44 ResultsInhibition
45 abnormal expression
46 accumulation
47 activity
48 anti-tumor potential
49 antisense inhibition
50 antisense oligodeoxynucleotides
51 apoptosis
52 apoptosis response
53 arrest
54 cell lines
55 cell proliferation
56 cells
57 chemotherapy
58 degradation
59 export
60 expression
61 feedback loop
62 feedback regulator
63 function
64 growth arrest
65 growth inhibition
66 increase
67 induction
68 inhibition
69 large panel
70 levels
71 lines
72 loop
73 low levels
74 maintenance
75 materials
76 most tumor types
77 negative feedback loop
78 negative feedback regulator
79 nuclear export
80 nuclear p53 accumulation
81 oligodeoxynucleotides
82 oncogene function
83 overexpression
84 p53
85 p53 accumulation
86 p53 degradation
87 p53 levels
88 p53 results
89 p53 transcriptional activity
90 p53 tumor suppressor
91 p53-mediated growth arrest
92 panel
93 phenotype
94 phosphorothioate antisense oligodeoxynucleotides
95 potential
96 proliferation
97 regulator
98 resistance
99 response
100 results
101 role
102 role of MDM2
103 significant induction
104 suppressor
105 transcriptional activity
106 tumor cell lines
107 tumor cells
108 tumor suppressor
109 tumor types
110 tumors
111 types
112 ubiquitous induction
113 wild-type p53 results
114 schema:name Ubiquitous Induction of p53 in Tumor Cells by Antisense Inhibition of MDM2 Expression
115 schema:pagination 21-34
116 schema:productId N1ea9c7ccfc9a490484473add22c699a1
117 N791bbf33f87f44d29a2ca3455a66c812
118 Nb5f1492183ba4e67b95649a2c841bfb8
119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074262577
120 https://doi.org/10.1007/bf03402136
121 schema:sdDatePublished 2022-11-24T20:50
122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
123 schema:sdPublisher N7df14eb525044312aadcf75e1c7615c3
124 schema:url https://doi.org/10.1007/bf03402136
125 sgo:license sg:explorer/license/
126 sgo:sdDataset articles
127 rdf:type schema:ScholarlyArticle
128 N04428b1d95234ba9872205b73277e8ba rdf:first sg:person.0774075322.41
129 rdf:rest Nc4119cd3f90240ea8047add9204a125d
130 N0dd966fc53324798b03715ae895e8cbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Tumor Cells, Cultured
132 rdf:type schema:DefinedTerm
133 N1ea9c7ccfc9a490484473add22c699a1 schema:name pubmed_id
134 schema:value 10072445
135 rdf:type schema:PropertyValue
136 N26e852192dae4c429ed9cc380828f71b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Phenotype
138 rdf:type schema:DefinedTerm
139 N27a3325d4b1648f99f65530d2edd873e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Choriocarcinoma
141 rdf:type schema:DefinedTerm
142 N316e93e8b4be482e8e97f52a42107f3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Gene Expression
144 rdf:type schema:DefinedTerm
145 N47bb66646b5f417985b19270fbe4c2c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Uterine Neoplasms
147 rdf:type schema:DefinedTerm
148 N51b99a84dc2a42e3aeb8c8dfeefe6c60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Genes, Tumor Suppressor
150 rdf:type schema:DefinedTerm
151 N52270872fb724b3b864183d251168e36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Genes, p53
153 rdf:type schema:DefinedTerm
154 N586dfdedf8cc46c8909b869f7cfbbdb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Proto-Oncogene Proteins c-mdm2
156 rdf:type schema:DefinedTerm
157 N610e6a9d4ec74036b56df68d541cf91e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Cell Division
159 rdf:type schema:DefinedTerm
160 N682824bd364d47ff8309d15e100a5408 rdf:first sg:person.011364334577.13
161 rdf:rest N8fc29fc0938d49ffa4164a3ff8d68ae4
162 N725a33a29e584dfa85c12e467266749d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Nuclear Proteins
164 rdf:type schema:DefinedTerm
165 N73fda4694c91457a9f6f4223787dd228 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Oligodeoxyribonucleotides, Antisense
167 rdf:type schema:DefinedTerm
168 N791bbf33f87f44d29a2ca3455a66c812 schema:name dimensions_id
169 schema:value pub.1074262577
170 rdf:type schema:PropertyValue
171 N7df14eb525044312aadcf75e1c7615c3 schema:name Springer Nature - SN SciGraph project
172 rdf:type schema:Organization
173 N8fc29fc0938d49ffa4164a3ff8d68ae4 rdf:first sg:person.01227525617.19
174 rdf:rest rdf:nil
175 Nb06860bcf4834a1eb7c575aa9093d2bf rdf:first sg:person.0711710767.48
176 rdf:rest N682824bd364d47ff8309d15e100a5408
177 Nb2b028d298cb4ca3910c63a1d611458d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Apoptosis
179 rdf:type schema:DefinedTerm
180 Nb4fc2f83485a4775967a23339d62f8ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Humans
182 rdf:type schema:DefinedTerm
183 Nb5f1492183ba4e67b95649a2c841bfb8 schema:name doi
184 schema:value 10.1007/bf03402136
185 rdf:type schema:PropertyValue
186 Nb7c6044baa6d4d9c9c474dfc6d3a257e rdf:first sg:person.012105024377.13
187 rdf:rest N04428b1d95234ba9872205b73277e8ba
188 Nc4119cd3f90240ea8047add9204a125d rdf:first sg:person.01124454740.04
189 rdf:rest Nb06860bcf4834a1eb7c575aa9093d2bf
190 Nc822b3a8285048d59ffcc0c1aabc7dbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Base Sequence
192 rdf:type schema:DefinedTerm
193 Nd64d9e1fc01548a4975a12c386bcb77b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Pregnancy
195 rdf:type schema:DefinedTerm
196 Nda3f841112e24e1b9541c059f1fcc21d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Female
198 rdf:type schema:DefinedTerm
199 Nddee424f6b5e441dac4db168b42790c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Tumor Suppressor Protein p53
201 rdf:type schema:DefinedTerm
202 Ne48e8ee25196487b81d16039d6608d9b schema:issueNumber 1
203 rdf:type schema:PublicationIssue
204 Nef851749f6e64bafabb9e83321ddc495 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Proto-Oncogene Proteins
206 rdf:type schema:DefinedTerm
207 Nef897d63ff3146c699d2c5e46f4050eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Molecular Sequence Data
209 rdf:type schema:DefinedTerm
210 Nf7df09e78aed4546be214de0ed82d420 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Feedback
212 rdf:type schema:DefinedTerm
213 Nf8a74ac9b5d545bd85598fba7f41e932 schema:volumeNumber 5
214 rdf:type schema:PublicationVolume
215 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
216 schema:name Biological Sciences
217 rdf:type schema:DefinedTerm
218 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
219 schema:name Biochemistry and Cell Biology
220 rdf:type schema:DefinedTerm
221 sg:journal.1113628 schema:issn 1076-1551
222 1528-3658
223 schema:name Molecular Medicine
224 schema:publisher Springer Nature
225 rdf:type schema:Periodical
226 sg:person.01124454740.04 schema:affiliation grid-institutes:grid.452508.e
227 schema:familyName Agrawal
228 schema:givenName Sudhir
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124454740.04
230 rdf:type schema:Person
231 sg:person.011364334577.13 schema:affiliation grid-institutes:grid.265892.2
232 schema:familyName Zhang
233 schema:givenName Ruiwen
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011364334577.13
235 rdf:type schema:Person
236 sg:person.012105024377.13 schema:affiliation grid-institutes:grid.470125.5
237 schema:familyName Chen
238 schema:givenName Lihong
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012105024377.13
240 rdf:type schema:Person
241 sg:person.01227525617.19 schema:affiliation grid-institutes:grid.470125.5
242 schema:familyName Chen
243 schema:givenName Jiandong
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227525617.19
245 rdf:type schema:Person
246 sg:person.0711710767.48 schema:affiliation grid-institutes:grid.452508.e
247 schema:familyName Zhou
248 schema:givenName Wenqiang
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711710767.48
250 rdf:type schema:Person
251 sg:person.0774075322.41 schema:affiliation grid-institutes:grid.470125.5
252 schema:familyName Lu
253 schema:givenName Wenge
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774075322.41
255 rdf:type schema:Person
256 sg:pub.10.1038/358080a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008811763
257 https://doi.org/10.1038/358080a0
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/362847a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032575717
260 https://doi.org/10.1038/362847a0
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/378203a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015059358
263 https://doi.org/10.1038/378203a0
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/378206a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007191650
266 https://doi.org/10.1038/378206a0
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/387296a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004301257
269 https://doi.org/10.1038/387296a0
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/387299a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037935695
272 https://doi.org/10.1038/387299a0
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/sj.onc.1201453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053233454
275 https://doi.org/10.1038/sj.onc.1201453
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/sj.onc.1201459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014670955
278 https://doi.org/10.1038/sj.onc.1201459
279 rdf:type schema:CreativeWork
280 grid-institutes:grid.265892.2 schema:alternateName Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama, USA
281 schema:name Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama, USA
282 rdf:type schema:Organization
283 grid-institutes:grid.452508.e schema:alternateName Hybridon, Inc., Cambridge, Massachusetts, USA
284 schema:name Hybridon, Inc., Cambridge, Massachusetts, USA
285 rdf:type schema:Organization
286 grid-institutes:grid.470125.5 schema:alternateName Department of Microbiology, Stanley S. Scott Cancer Center, Louisiana State University Medical Center, 1901 Perdido Street, 70112, New Orleans, LA, USA
287 schema:name Department of Microbiology, Stanley S. Scott Cancer Center, Louisiana State University Medical Center, 1901 Perdido Street, 70112, New Orleans, LA, USA
288 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...