Molecular Evidence-Based Use of Bone Resorption-Targeted Therapy in Prostate Cancer Patients at High Risk for Bone Involvement View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-11

AUTHORS

Dimitrios Karamanolakis, John Bogdanos, Antigone Sourla, Constantine Milathianakis, Athanassios Tsintavis, Peter Lembessis, Roxane Tenta, Despina Tiblalexi, Michael Koutsilieris

ABSTRACT

BACKGROUND: To improve median survival of patients with prostate cancer that has metastasized to bone, we need to better understand the early events of the metastatic process in skeleton and develop molecular tools capable of detecting the early tumor cell dissemination into bones (micrometastasis stage). However, the initial phase of tumor cell dissemination into the bone marrow is promptly followed by the migration of tumor cells into bone matrix, which is a crucial step that signals the transformation of micrometastasis to macrometastasis stage and clinically evident metastasis. The migration of cancer cells into bone matrix requires the activation of local bone resorption. Such an event contributes to tumor cell hiding/ escaping from high immunologic surveillance of bone marrow cells. Within bone matrix, tumor cells are establishing plethoric cell-cell interactions with bone marrow-residing cells, ensuring their survival and growth. Recently, RT-PCR detections of tumor marker transcripts, such as PSA and PSMA mRNA performed in RNA extracts of peripheral blood nucleated cells and bone marrow biopsy, have enabled the stratification of patients with clinically localized prostate cancer being of high risk for extraprostatic disease and bone involvement. Therefore, it is conceivable that bisphosphonate blockade of bone resorption can inhibit the migration of tumor cells into bone matrix during the early phase of disease dissemination into bone marrow (micrometastasis stage). Consequently, assessment of the efficacy and efficiency of bisphosphonates to arrest the evolution of bone lesions in this particular clinical setting of patients with clinically localized prostate cancer and positive molecular staging status (high risk for bone involvement) is warranted. More... »

PAGES

667-675

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03402030

DOI

http://dx.doi.org/10.1007/bf03402030

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1075215478

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12520083


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Resorption", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diphosphonates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evidence-Based Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, 115 27, Goudi-Athens, Greece", 
            "Urology Clinic, \u201cMETAXA\u201d Anticancer Hospital, Piraeus, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karamanolakis", 
        "givenName": "Dimitrios", 
        "id": "sg:person.0651737555.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651737555.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, 115 27, Goudi-Athens, Greece", 
            "Urology Clinic, \u201cMETAXA\u201d Anticancer Hospital, Piraeus, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bogdanos", 
        "givenName": "John", 
        "id": "sg:person.01142335221.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142335221.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Endo/OncoResearch Diagnostic & Therapeutic Medical Center, Platia Mavilis, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sourla", 
        "givenName": "Antigone", 
        "id": "sg:person.0750525645.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750525645.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, 115 27, Goudi-Athens, Greece", 
            "Urology Clinic, \u201cMETAXA\u201d Anticancer Hospital, Piraeus, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milathianakis", 
        "givenName": "Constantine", 
        "id": "sg:person.01210450421.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210450421.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Urology Clinic, \u201cMETAXA\u201d Anticancer Hospital, Piraeus, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsintavis", 
        "givenName": "Athanassios", 
        "id": "sg:person.01152127450.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152127450.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, 115 27, Goudi-Athens, Greece", 
            "Endo/OncoResearch Diagnostic & Therapeutic Medical Center, Platia Mavilis, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lembessis", 
        "givenName": "Peter", 
        "id": "sg:person.01323314706.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323314706.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, 115 27, Goudi-Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tenta", 
        "givenName": "Roxane", 
        "id": "sg:person.01125531320.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125531320.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, 115 27, Goudi-Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tiblalexi", 
        "givenName": "Despina", 
        "id": "sg:person.01173644520.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173644520.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Experimental Physiology, Medical School, University of Athens, 115 27, Goudi-Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koutsilieris", 
        "givenName": "Michael", 
        "id": "sg:person.0733537100.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733537100.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/1097-0142(19950401)75:7<1642::aid-cncr2820750714>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000880136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.1993.tb16269.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002345455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s8756-3282(97)00289-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002874099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-4295(98)00182-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003279232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(01)65196-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004124840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.1992.tb15461.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005108309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s8756-3282(01)00592-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007263281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.1995.tb07715.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008519491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/263507a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009955142", 
          "https://doi.org/10.1038/263507a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1464-410x.1996.82817.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010454091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1464-410x.1996.90616.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010948740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.1998.13.4.581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011329277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/13543784.10.6.1099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012312469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197508)36:2<359::aid-cncr2820360210>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013636447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.1997.12.9.1358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013654064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-4295(96)00235-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014621784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)92054-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014742515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)92054-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014742515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(01)67407-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014826147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199808063390609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015277195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(01)01548-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017489440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018880454", 
          "https://doi.org/10.1038/bjc.1998.658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018880454", 
          "https://doi.org/10.1038/bjc.1998.658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19830301)51:5<918::aid-cncr2820510526>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018933967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(89)92665-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019371397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(89)92665-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019371397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006783330996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020794743", 
          "https://doi.org/10.1023/a:1006783330996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/13543784.11.2.283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021919522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0995-944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024492051", 
          "https://doi.org/10.1038/nm0995-944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.5650140212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024723117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0093-7754(01)90230-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024915373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-8049(94)90287-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025865659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-4295(88)90410-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027528165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027918457", 
          "https://doi.org/10.1038/bjc.1997.114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027918457", 
          "https://doi.org/10.1038/bjc.1997.114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20000615)88:12+<3047::aid-cncr22>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028585235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(89)93028-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029267696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02549644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031908967", 
          "https://doi.org/10.1007/bf02549644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02549644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031908967", 
          "https://doi.org/10.1007/bf02549644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.1985.tb07040.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035562945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198908173210702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036523041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1581::aid-cncr8>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039638941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1546::aid-cncr4>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042904616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.1991.tb15260.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046555793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-83668-8_6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047203715", 
          "https://doi.org/10.1007/978-3-642-83668-8_6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-4295(98)00658-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047587338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(01)64472-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049364706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1040-8428(94)00122-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050119200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1999.tb07702.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050409352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1999.tb07702.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050409352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051466690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.2990040606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051894897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.1999.14.5.722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052827500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-4295(86)90278-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053564397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198209000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060159932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198209000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060159932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198209000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060159932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/edrv.20.3.0367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064238469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.140.10.7037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064282686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.19.1.18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064285717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.86.12.8119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064324084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074652720", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03401935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074687025", 
          "https://doi.org/10.1007/bf03401935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074795176", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074999538", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078444698", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078491972", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(17)40597-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078878870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(17)47663-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079460077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079556210", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1985.3.7.1013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080019121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082386855", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082399331", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082401776", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082465185", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082841361", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083100674", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083151234", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.3.1218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083229180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083241031", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347139", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-11", 
    "datePublishedReg": "2002-11-01", 
    "description": "BACKGROUND: To improve median survival of patients with prostate cancer that has metastasized to bone, we need to better understand the early events of the metastatic process in skeleton and develop molecular tools capable of detecting the early tumor cell dissemination into bones (micrometastasis stage). However, the initial phase of tumor cell dissemination into the bone marrow is promptly followed by the migration of tumor cells into bone matrix, which is a crucial step that signals the transformation of micrometastasis to macrometastasis stage and clinically evident metastasis. The migration of cancer cells into bone matrix requires the activation of local bone resorption. Such an event contributes to tumor cell hiding/ escaping from high immunologic surveillance of bone marrow cells. Within bone matrix, tumor cells are establishing plethoric cell-cell interactions with bone marrow-residing cells, ensuring their survival and growth. Recently, RT-PCR detections of tumor marker transcripts, such as PSA and PSMA mRNA performed in RNA extracts of peripheral blood nucleated cells and bone marrow biopsy, have enabled the stratification of patients with clinically localized prostate cancer being of high risk for extraprostatic disease and bone involvement. Therefore, it is conceivable that bisphosphonate blockade of bone resorption can inhibit the migration of tumor cells into bone matrix during the early phase of disease dissemination into bone marrow (micrometastasis stage). Consequently, assessment of the efficacy and efficiency of bisphosphonates to arrest the evolution of bone lesions in this particular clinical setting of patients with clinically localized prostate cancer and positive molecular staging status (high risk for bone involvement) is warranted.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf03402030", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1113628", 
        "issn": [
          "1076-1551", 
          "1528-3658"
        ], 
        "name": "Molecular Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Molecular Evidence-Based Use of Bone Resorption-Targeted Therapy in Prostate Cancer Patients at High Risk for Bone Involvement", 
    "pagination": "667-675", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "51f4f76b87c807c7289fcd8b083fd5aeb9b3aba7a1aa23c80e188a086de2f4ff"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12520083"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9501023"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf03402030"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1075215478"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf03402030", 
      "https://app.dimensions.ai/details/publication/pub.1075215478"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000528.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2FBF03402030"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf03402030'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf03402030'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf03402030'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf03402030'


 

This table displays all metadata directly associated to this object as RDF triples.

399 TRIPLES      21 PREDICATES      116 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf03402030 schema:about N1f2bd7a0803d47faa06fb238aeaada9c
2 N3503510739dc44fa82c9a21fb2ce3d2b
3 N4dd3778f6eb54df0b88d0a324e8790a5
4 N5dbbfe6602534035906686f46bb782c9
5 N6109eb02775349bcb0b399c90e2e31bd
6 N64108784b13b497fb4d39860113cd7c7
7 N6f4be53fbab54d17b1c8ad715b5d18dc
8 N898548aa966b4c1aa1d1b7e8f21b4192
9 N9f6daab093a0436688bf3db23108f497
10 Na433412ffea24f3895e0688f7f96f12c
11 Nd6fdd942cf6b42ec81a43aa363cf2028
12 Ne05df60cd43141c486cc1ca49894a155
13 Neff2832dda4041fdad87e794f6347ea4
14 Nf9867d32a0514a1c905b03e36bfdd17d
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author N83986eada9e342639c0ddea51d50ff8b
18 schema:citation sg:pub.10.1007/978-3-642-83668-8_6
19 sg:pub.10.1007/bf02549644
20 sg:pub.10.1007/bf03401935
21 sg:pub.10.1023/a:1006783330996
22 sg:pub.10.1038/263507a0
23 sg:pub.10.1038/bjc.1997.114
24 sg:pub.10.1038/bjc.1998.658
25 sg:pub.10.1038/nm0995-944
26 https://app.dimensions.ai/details/publication/pub.1074652720
27 https://app.dimensions.ai/details/publication/pub.1074795176
28 https://app.dimensions.ai/details/publication/pub.1074999538
29 https://app.dimensions.ai/details/publication/pub.1078444698
30 https://app.dimensions.ai/details/publication/pub.1078491972
31 https://app.dimensions.ai/details/publication/pub.1079556210
32 https://app.dimensions.ai/details/publication/pub.1082386855
33 https://app.dimensions.ai/details/publication/pub.1082399331
34 https://app.dimensions.ai/details/publication/pub.1082401776
35 https://app.dimensions.ai/details/publication/pub.1082465185
36 https://app.dimensions.ai/details/publication/pub.1082841361
37 https://app.dimensions.ai/details/publication/pub.1083100674
38 https://app.dimensions.ai/details/publication/pub.1083151234
39 https://app.dimensions.ai/details/publication/pub.1083241031
40 https://app.dimensions.ai/details/publication/pub.1083347139
41 https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1546::aid-cncr4>3.0.co;2-i
42 https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1581::aid-cncr8>3.0.co;2-n
43 https://doi.org/10.1002/1097-0142(197508)36:2<359::aid-cncr2820360210>3.0.co;2-1
44 https://doi.org/10.1002/1097-0142(19830301)51:5<918::aid-cncr2820510526>3.0.co;2-j
45 https://doi.org/10.1002/1097-0142(19950401)75:7<1642::aid-cncr2820750714>3.0.co;2-1
46 https://doi.org/10.1002/1097-0142(20000615)88:12+<3047::aid-cncr22>3.0.co;2-u
47 https://doi.org/10.1002/jbmr.5650140212
48 https://doi.org/10.1002/pros.2990040606
49 https://doi.org/10.1016/0090-4295(86)90278-5
50 https://doi.org/10.1016/0090-4295(88)90410-4
51 https://doi.org/10.1016/0959-8049(94)90287-9
52 https://doi.org/10.1016/1040-8428(94)00122-a
53 https://doi.org/10.1016/s0022-5347(01)64472-0
54 https://doi.org/10.1016/s0022-5347(01)65196-6
55 https://doi.org/10.1016/s0022-5347(01)67407-x
56 https://doi.org/10.1016/s0022-5347(17)40597-0
57 https://doi.org/10.1016/s0022-5347(17)47663-4
58 https://doi.org/10.1016/s0024-3205(01)01548-x
59 https://doi.org/10.1016/s0090-4295(96)00235-x
60 https://doi.org/10.1016/s0090-4295(98)00182-4
61 https://doi.org/10.1016/s0090-4295(98)00658-x
62 https://doi.org/10.1016/s0093-7754(01)90230-1
63 https://doi.org/10.1016/s0140-6736(89)92665-2
64 https://doi.org/10.1016/s0140-6736(89)93028-6
65 https://doi.org/10.1016/s0140-6736(95)92054-4
66 https://doi.org/10.1016/s8756-3282(01)00592-0
67 https://doi.org/10.1016/s8756-3282(97)00289-5
68 https://doi.org/10.1046/j.1464-410x.1996.82817.x
69 https://doi.org/10.1046/j.1464-410x.1996.90616.x
70 https://doi.org/10.1056/nejm198908173210702
71 https://doi.org/10.1056/nejm199808063390609
72 https://doi.org/10.1097/00003086-198209000-00004
73 https://doi.org/10.1111/j.1464-410x.1985.tb07040.x
74 https://doi.org/10.1111/j.1464-410x.1991.tb15260.x
75 https://doi.org/10.1111/j.1464-410x.1992.tb15461.x
76 https://doi.org/10.1111/j.1464-410x.1993.tb16269.x
77 https://doi.org/10.1111/j.1464-410x.1995.tb07715.x
78 https://doi.org/10.1111/j.1749-6632.1999.tb07702.x
79 https://doi.org/10.1172/jci118841
80 https://doi.org/10.1200/jco.1985.3.7.1013
81 https://doi.org/10.1200/jco.1998.16.3.1218
82 https://doi.org/10.1210/edrv.20.3.0367
83 https://doi.org/10.1210/endo.140.10.7037
84 https://doi.org/10.1210/er.19.1.18
85 https://doi.org/10.1210/jcem.86.12.8119
86 https://doi.org/10.1359/jbmr.1997.12.9.1358
87 https://doi.org/10.1359/jbmr.1998.13.4.581
88 https://doi.org/10.1359/jbmr.1999.14.5.722
89 https://doi.org/10.1517/13543784.10.6.1099
90 https://doi.org/10.1517/13543784.11.2.283
91 schema:datePublished 2002-11
92 schema:datePublishedReg 2002-11-01
93 schema:description BACKGROUND: To improve median survival of patients with prostate cancer that has metastasized to bone, we need to better understand the early events of the metastatic process in skeleton and develop molecular tools capable of detecting the early tumor cell dissemination into bones (micrometastasis stage). However, the initial phase of tumor cell dissemination into the bone marrow is promptly followed by the migration of tumor cells into bone matrix, which is a crucial step that signals the transformation of micrometastasis to macrometastasis stage and clinically evident metastasis. The migration of cancer cells into bone matrix requires the activation of local bone resorption. Such an event contributes to tumor cell hiding/ escaping from high immunologic surveillance of bone marrow cells. Within bone matrix, tumor cells are establishing plethoric cell-cell interactions with bone marrow-residing cells, ensuring their survival and growth. Recently, RT-PCR detections of tumor marker transcripts, such as PSA and PSMA mRNA performed in RNA extracts of peripheral blood nucleated cells and bone marrow biopsy, have enabled the stratification of patients with clinically localized prostate cancer being of high risk for extraprostatic disease and bone involvement. Therefore, it is conceivable that bisphosphonate blockade of bone resorption can inhibit the migration of tumor cells into bone matrix during the early phase of disease dissemination into bone marrow (micrometastasis stage). Consequently, assessment of the efficacy and efficiency of bisphosphonates to arrest the evolution of bone lesions in this particular clinical setting of patients with clinically localized prostate cancer and positive molecular staging status (high risk for bone involvement) is warranted.
94 schema:genre research_article
95 schema:inLanguage en
96 schema:isAccessibleForFree true
97 schema:isPartOf Ne0cc00599e14472290c362026f9fd761
98 Nf200aeee1d3d417292f6cda5e74853fd
99 sg:journal.1113628
100 schema:name Molecular Evidence-Based Use of Bone Resorption-Targeted Therapy in Prostate Cancer Patients at High Risk for Bone Involvement
101 schema:pagination 667-675
102 schema:productId N47b528627f3643038ff944e51f174867
103 N883fc533652e4a52aef8abf88ceaeaa2
104 Na02034ff9a18486e8b9dee3142a4e6a2
105 Na3afc270848e442681a3a8a6d6767798
106 Nb05e76026fe34634a04ced97944f2748
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075215478
108 https://doi.org/10.1007/bf03402030
109 schema:sdDatePublished 2019-04-10T21:40
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher Na704b857f44e4913a55a814d31df1ede
112 schema:url http://link.springer.com/10.1007%2FBF03402030
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N0de531de5f784965a53ccd90496f199c schema:name Urology Clinic, “METAXA” Anticancer Hospital, Piraeus, Greece
117 rdf:type schema:Organization
118 N1f2bd7a0803d47faa06fb238aeaada9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Male
120 rdf:type schema:DefinedTerm
121 N2ecb2cb9f5914094b259049c08c9e0ef rdf:first sg:person.01152127450.59
122 rdf:rest N3898e6bef5834e15ab637afee9908f6f
123 N3503510739dc44fa82c9a21fb2ce3d2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Prostatic Neoplasms
125 rdf:type schema:DefinedTerm
126 N3898e6bef5834e15ab637afee9908f6f rdf:first sg:person.01323314706.89
127 rdf:rest N715ab6a6589f470cb7890a7504f74d2c
128 N47b528627f3643038ff944e51f174867 schema:name nlm_unique_id
129 schema:value 9501023
130 rdf:type schema:PropertyValue
131 N496a692b9a9d4fb7b4c684a064ff8da8 schema:name Endo/OncoResearch Diagnostic & Therapeutic Medical Center, Platia Mavilis, Athens, Greece
132 rdf:type schema:Organization
133 N4dd3778f6eb54df0b88d0a324e8790a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Diphosphonates
135 rdf:type schema:DefinedTerm
136 N5dbbfe6602534035906686f46bb782c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Bone Neoplasms
138 rdf:type schema:DefinedTerm
139 N6109eb02775349bcb0b399c90e2e31bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name RNA, Neoplasm
141 rdf:type schema:DefinedTerm
142 N64108784b13b497fb4d39860113cd7c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Biomarkers, Tumor
144 rdf:type schema:DefinedTerm
145 N6f4be53fbab54d17b1c8ad715b5d18dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Bone Resorption
147 rdf:type schema:DefinedTerm
148 N715ab6a6589f470cb7890a7504f74d2c rdf:first sg:person.01125531320.59
149 rdf:rest N797d76376a95494f8ae230c10e917db5
150 N771fca1ce6724905a78862f7b195fc8e rdf:first sg:person.01142335221.83
151 rdf:rest Na3bee63da1d44702af6bca74698b5b28
152 N797d76376a95494f8ae230c10e917db5 rdf:first sg:person.01173644520.70
153 rdf:rest Nf88de34044da448a96f078095520642b
154 N83986eada9e342639c0ddea51d50ff8b rdf:first sg:person.0651737555.43
155 rdf:rest N771fca1ce6724905a78862f7b195fc8e
156 N883fc533652e4a52aef8abf88ceaeaa2 schema:name dimensions_id
157 schema:value pub.1075215478
158 rdf:type schema:PropertyValue
159 N898548aa966b4c1aa1d1b7e8f21b4192 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Cell Movement
161 rdf:type schema:DefinedTerm
162 N99547761c1d7479a8e2d6d3a7e4f9b21 rdf:first sg:person.01210450421.25
163 rdf:rest N2ecb2cb9f5914094b259049c08c9e0ef
164 N9f6daab093a0436688bf3db23108f497 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Reverse Transcriptase Polymerase Chain Reaction
166 rdf:type schema:DefinedTerm
167 Na02034ff9a18486e8b9dee3142a4e6a2 schema:name pubmed_id
168 schema:value 12520083
169 rdf:type schema:PropertyValue
170 Na3afc270848e442681a3a8a6d6767798 schema:name doi
171 schema:value 10.1007/bf03402030
172 rdf:type schema:PropertyValue
173 Na3bee63da1d44702af6bca74698b5b28 rdf:first sg:person.0750525645.03
174 rdf:rest N99547761c1d7479a8e2d6d3a7e4f9b21
175 Na433412ffea24f3895e0688f7f96f12c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name RNA, Messenger
177 rdf:type schema:DefinedTerm
178 Na704b857f44e4913a55a814d31df1ede schema:name Springer Nature - SN SciGraph project
179 rdf:type schema:Organization
180 Nb05e76026fe34634a04ced97944f2748 schema:name readcube_id
181 schema:value 51f4f76b87c807c7289fcd8b083fd5aeb9b3aba7a1aa23c80e188a086de2f4ff
182 rdf:type schema:PropertyValue
183 Nd6fdd942cf6b42ec81a43aa363cf2028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Humans
185 rdf:type schema:DefinedTerm
186 Ne05df60cd43141c486cc1ca49894a155 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Lymphatic Metastasis
188 rdf:type schema:DefinedTerm
189 Ne0cc00599e14472290c362026f9fd761 schema:issueNumber 11
190 rdf:type schema:PublicationIssue
191 Neff2832dda4041fdad87e794f6347ea4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Antineoplastic Agents
193 rdf:type schema:DefinedTerm
194 Nf200aeee1d3d417292f6cda5e74853fd schema:volumeNumber 8
195 rdf:type schema:PublicationVolume
196 Nf88de34044da448a96f078095520642b rdf:first sg:person.0733537100.43
197 rdf:rest rdf:nil
198 Nf9867d32a0514a1c905b03e36bfdd17d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Evidence-Based Medicine
200 rdf:type schema:DefinedTerm
201 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
202 schema:name Biological Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
205 schema:name Biochemistry and Cell Biology
206 rdf:type schema:DefinedTerm
207 sg:journal.1113628 schema:issn 1076-1551
208 1528-3658
209 schema:name Molecular Medicine
210 rdf:type schema:Periodical
211 sg:person.01125531320.59 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
212 schema:familyName Tenta
213 schema:givenName Roxane
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125531320.59
215 rdf:type schema:Person
216 sg:person.01142335221.83 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
217 schema:familyName Bogdanos
218 schema:givenName John
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142335221.83
220 rdf:type schema:Person
221 sg:person.01152127450.59 schema:affiliation N0de531de5f784965a53ccd90496f199c
222 schema:familyName Tsintavis
223 schema:givenName Athanassios
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152127450.59
225 rdf:type schema:Person
226 sg:person.01173644520.70 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
227 schema:familyName Tiblalexi
228 schema:givenName Despina
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173644520.70
230 rdf:type schema:Person
231 sg:person.01210450421.25 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
232 schema:familyName Milathianakis
233 schema:givenName Constantine
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210450421.25
235 rdf:type schema:Person
236 sg:person.01323314706.89 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
237 schema:familyName Lembessis
238 schema:givenName Peter
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323314706.89
240 rdf:type schema:Person
241 sg:person.0651737555.43 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
242 schema:familyName Karamanolakis
243 schema:givenName Dimitrios
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651737555.43
245 rdf:type schema:Person
246 sg:person.0733537100.43 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
247 schema:familyName Koutsilieris
248 schema:givenName Michael
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733537100.43
250 rdf:type schema:Person
251 sg:person.0750525645.03 schema:affiliation N496a692b9a9d4fb7b4c684a064ff8da8
252 schema:familyName Sourla
253 schema:givenName Antigone
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750525645.03
255 rdf:type schema:Person
256 sg:pub.10.1007/978-3-642-83668-8_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047203715
257 https://doi.org/10.1007/978-3-642-83668-8_6
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/bf02549644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031908967
260 https://doi.org/10.1007/bf02549644
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/bf03401935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074687025
263 https://doi.org/10.1007/bf03401935
264 rdf:type schema:CreativeWork
265 sg:pub.10.1023/a:1006783330996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020794743
266 https://doi.org/10.1023/a:1006783330996
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/263507a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009955142
269 https://doi.org/10.1038/263507a0
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/bjc.1997.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027918457
272 https://doi.org/10.1038/bjc.1997.114
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/bjc.1998.658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018880454
275 https://doi.org/10.1038/bjc.1998.658
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nm0995-944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024492051
278 https://doi.org/10.1038/nm0995-944
279 rdf:type schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1074652720 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1074795176 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1074999538 schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1078444698 schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1078491972 schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1079556210 schema:CreativeWork
286 https://app.dimensions.ai/details/publication/pub.1082386855 schema:CreativeWork
287 https://app.dimensions.ai/details/publication/pub.1082399331 schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1082401776 schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1082465185 schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1082841361 schema:CreativeWork
291 https://app.dimensions.ai/details/publication/pub.1083100674 schema:CreativeWork
292 https://app.dimensions.ai/details/publication/pub.1083151234 schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1083241031 schema:CreativeWork
294 https://app.dimensions.ai/details/publication/pub.1083347139 schema:CreativeWork
295 https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1546::aid-cncr4>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1042904616
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/(sici)1097-0142(19971015)80:8+<1581::aid-cncr8>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1039638941
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1002/1097-0142(197508)36:2<359::aid-cncr2820360210>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013636447
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1002/1097-0142(19830301)51:5<918::aid-cncr2820510526>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1018933967
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/1097-0142(19950401)75:7<1642::aid-cncr2820750714>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000880136
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1002/1097-0142(20000615)88:12+<3047::aid-cncr22>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1028585235
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1002/jbmr.5650140212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024723117
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1002/pros.2990040606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051894897
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/0090-4295(86)90278-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053564397
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/0090-4295(88)90410-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027528165
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/0959-8049(94)90287-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025865659
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/1040-8428(94)00122-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1050119200
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/s0022-5347(01)64472-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049364706
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/s0022-5347(01)65196-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004124840
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0022-5347(01)67407-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014826147
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s0022-5347(17)40597-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078878870
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s0022-5347(17)47663-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079460077
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s0024-3205(01)01548-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017489440
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s0090-4295(96)00235-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014621784
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s0090-4295(98)00182-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003279232
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/s0090-4295(98)00658-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047587338
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/s0093-7754(01)90230-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024915373
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/s0140-6736(89)92665-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019371397
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/s0140-6736(89)93028-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029267696
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/s0140-6736(95)92054-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014742515
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/s8756-3282(01)00592-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007263281
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/s8756-3282(97)00289-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002874099
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1046/j.1464-410x.1996.82817.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010454091
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1046/j.1464-410x.1996.90616.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010948740
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1056/nejm198908173210702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036523041
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1056/nejm199808063390609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015277195
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1097/00003086-198209000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060159932
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1111/j.1464-410x.1985.tb07040.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035562945
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1111/j.1464-410x.1991.tb15260.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046555793
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1111/j.1464-410x.1992.tb15461.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005108309
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1111/j.1464-410x.1993.tb16269.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002345455
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1111/j.1464-410x.1995.tb07715.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008519491
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1111/j.1749-6632.1999.tb07702.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050409352
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1172/jci118841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051466690
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1200/jco.1985.3.7.1013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080019121
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1200/jco.1998.16.3.1218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083229180
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1210/edrv.20.3.0367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064238469
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1210/endo.140.10.7037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064282686
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1210/er.19.1.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285717
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1210/jcem.86.12.8119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064324084
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1359/jbmr.1997.12.9.1358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013654064
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1359/jbmr.1998.13.4.581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011329277
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1359/jbmr.1999.14.5.722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052827500
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1517/13543784.10.6.1099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012312469
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1517/13543784.11.2.283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021919522
394 rdf:type schema:CreativeWork
395 https://www.grid.ac/institutes/grid.5216.0 schema:alternateName National and Kapodistrian University of Athens
396 schema:name Department of Experimental Physiology, Medical School, University of Athens, 115 27, Goudi-Athens, Greece
397 Endo/OncoResearch Diagnostic & Therapeutic Medical Center, Platia Mavilis, Athens, Greece
398 Urology Clinic, “METAXA” Anticancer Hospital, Piraeus, Greece
399 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...