Vacor inhibits insulin release from islets in vitro View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-04

AUTHORS

H. Taniguchi, Y. Yamashiro, M. Y. Chung, Y. Hara, K. Ishihara, K. Ejiri, S. Baba

ABSTRACT

It has been reported that Vacor, a rodenticide containing N-3-pyridylmethyl-N’-p-nitrophenyl urea, causes insulin-dependent diabetes mellitus. The pathomechanism of Vacor-induced diabetes mellitus has not been clarified yet. The effect of Vacor, therefore, was studied in terms of insulin release from isolated rat pancreatic islets. Vacor suppressed glucose-stimulated insulin release, but did not affect the insulin release induced by theophylline or 12-o-tetra-decanoylphorbol 13-acetate. It is suspected that the suppression of insulin release from pancreatic islets by Vacor may contribute to the pathogenesis of Vacor-induced diabetes mellitus and that this suppression might not be related to cAMP and C-kinase. More... »

PAGES

273-275

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03349985

DOI

http://dx.doi.org/10.1007/bf03349985

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039368990

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2663966


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