Graves’ IgG stimulation of iodide uptake in FRTL-5 rat thyroid cells: A clinical assay complementing FRTL-5 assays measuring adenylate cyclase ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-12

AUTHORS

C. Marcocci, W. A. Valente, A. Pinchera, S. M. Aloj, L. D. Kohn, E. F. Grollman

ABSTRACT

With optimal conditions and cells maintained in the absence of thyrotropin (TSH) for 7-10 days, IgG preparations from approximately 90% of patients with active Graves' disease can exhibit statistically significant stimulation of cAMP levels in rat FRTL-5 thyroid cells as compared to normal controls. FRTL-5 cells maintained in the absence of TSH for 7-10 days lose their ability to take up iodide. Iodide uptake returns upon readdition of TSH over a 60-hour period via a cAMP-mediated process; thus TSH can be replaced by dibutyryl cAMP or other agents which increase cAMP levels, for example, thyroid-stimulating autoantibodies (TSAbs) from Graves' sera. TSAb stimulation of iodide uptake requires the continued presence of TSAb over at least the first 24 hours of a 48-hour reversal period; TSH, in contrast, can be withdrawn after 5 hours and will still achieve maximal effects at 36-48 hours. Iodide uptake, measured as a 30-minute pulse at 48 hours, appears, however, to be faster with TSAb than TSH. With optimized conditions (cells depleted of TSH greater than 7-10 days; 3-isobytyl-1-methyl xanthine, 0.005 mM; TSAb addition for the entire 48-hour assay period; and a 30-minute pulse of 10 microM 125I-sodium iodide at 37 C), TSAb stimulation is concentration-dependent with a half-maximal activity at approximately 10-fold lower concentrations than in the cAMP stimulation assay. In a series of 24 patients with Graves' disease, IgGs with positive values in the cAMP assay were positive in the iodide uptake assay.(ABSTRACT TRUNCATED AT 250 WORDS) More... »

PAGES

463-471

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03348346

DOI

http://dx.doi.org/10.1007/bf03348346

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043709038

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6689493


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