Dissociation between tumor shrinkage and hormonal response during somatostatin analog treatment in an acromegalic patient: Preferential expression of somatostatin receptor ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-10

AUTHORS

A. P. M. Casarini, E. M. Pinto, R. S. Jallad, R. R. Giorgi, D. Giannella-Neto, M. D. Bronstein

ABSTRACT

INTRODUCTION: About a third of acromegalic patients is resistant to available SS analogs (SA), octreotide (OCT) and lanreotide (LAN). Such resistance is related to reduction of SS receptor (SSTR) density or to a different expression of SSTR subtypes. There are 5 known SSTR subtypes. SSTR2 and SSTR5 are usually expressed in GH-secreting pituitary tumors, and both SA bind preferentially to SSTR2 and, to a lesser extent, to SSTR5. We herein describe an acromegalic patient who presented impressive tumor shrinkage without hormonal normalization during primary therapy with SA. MATERIAL AND METHODS: This 23-yr-old male acromegalic patient was treated with slow-release LAN (LAN-SR), 30 mg every 10 days for six months, followed by OCT-LAR, 30 mg every 28 days for an additional six months with a 75% tumor volume reduction but without GH and IGF-I normalization. Subsequently, he underwent pituitary surgery and expression of SSTR in the removed tumor was performed by real time RT-PCR by the 2-deltaCt method, using GAPDH as internal control. All PCR products were confirmed by automated sequencing. RESULTS: SSTR expression revealed an unusual profile, with almost exclusively expression of SSTR3. CONCLUSIONS: These unusual clinical and receptor subtypes profile suggest an important role of SSTR3 on tumor shrinkage. The low affinity of LAN and OCT for this SSTR subtype could be compensated by its high expression in this GH-secreting pituitary macroadenoma. More... »

PAGES

826-830

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03347378

DOI

http://dx.doi.org/10.1007/bf03347378

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008982520

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17114915


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acromegaly", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Growth Hormone-Secreting Pituitary Adenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Human Growth Hormone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Like Growth Factor I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Octreotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides, Cyclic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pituitary Gland", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Somatostatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Remission Induction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Somatostatin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Laboratory Cellular and Molecular Endocrinology (LIM25), University of Sao Paulo Medical School, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Casarini", 
        "givenName": "A. P. M.", 
        "id": "sg:person.01330730262.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330730262.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Endocrine and Development Unit Laboratory of Hormone and Molecular Genetics (LIM42), University of Sao Paulo Medical School, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinto", 
        "givenName": "E. M.", 
        "id": "sg:person.01234624673.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234624673.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital of Cl\u00ednicas, University of Sao Paulo Medical School, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jallad", 
        "givenName": "R. S.", 
        "id": "sg:person.01330775246.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330775246.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Laboratory Cellular and Molecular Endocrinology (LIM25), University of Sao Paulo Medical School, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giorgi", 
        "givenName": "R. R.", 
        "id": "sg:person.01172355325.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172355325.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Laboratory Cellular and Molecular Endocrinology (LIM25), University of Sao Paulo Medical School, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giannella-Neto", 
        "givenName": "D.", 
        "id": "sg:person.0701547225.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701547225.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital of Cl\u00ednicas, University of Sao Paulo Medical School, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bronstein", 
        "givenName": "M. D.", 
        "id": "sg:person.0701373340.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701373340.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1472-6750-3-18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003492027", 
          "https://doi.org/10.1186/1472-6750-3-18"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0026-0495(96)90085-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015966070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2826.2003.01077.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023958773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0889-8529(05)70062-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031163682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0889-8529(05)70062-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031163682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0026-0495(96)90072-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032023135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.2005.02317.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032107093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.2005.02317.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032107093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000047824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034849820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035012001", 
          "https://doi.org/10.1038/labinvest.3700303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035012001", 
          "https://doi.org/10.1038/labinvest.3700303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035012001", 
          "https://doi.org/10.1038/labinvest.3700303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035012001", 
          "https://doi.org/10.1038/labinvest.3700303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(95)02082-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036017807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2004-1093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041330747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/frne.1999.0183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043191743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0136771100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050804370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.135.6.7988476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064279666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2002-021825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064286547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2003-030303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064286795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2005-0633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064288451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.83.8.2646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064300335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.85.2.526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064301229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.85.2.781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064301265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.86.7.2976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064302005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.10.12.8961277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.11.11.0016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082977090", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083181356", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-10", 
    "datePublishedReg": "2006-10-01", 
    "description": "INTRODUCTION: About a third of acromegalic patients is resistant to available SS analogs (SA), octreotide (OCT) and lanreotide (LAN). Such resistance is related to reduction of SS receptor (SSTR) density or to a different expression of SSTR subtypes. There are 5 known SSTR subtypes. SSTR2 and SSTR5 are usually expressed in GH-secreting pituitary tumors, and both SA bind preferentially to SSTR2 and, to a lesser extent, to SSTR5. We herein describe an acromegalic patient who presented impressive tumor shrinkage without hormonal normalization during primary therapy with SA.\nMATERIAL AND METHODS: This 23-yr-old male acromegalic patient was treated with slow-release LAN (LAN-SR), 30 mg every 10 days for six months, followed by OCT-LAR, 30 mg every 28 days for an additional six months with a 75% tumor volume reduction but without GH and IGF-I normalization. Subsequently, he underwent pituitary surgery and expression of SSTR in the removed tumor was performed by real time RT-PCR by the 2-deltaCt method, using GAPDH as internal control. All PCR products were confirmed by automated sequencing.\nRESULTS: SSTR expression revealed an unusual profile, with almost exclusively expression of SSTR3.\nCONCLUSIONS: These unusual clinical and receptor subtypes profile suggest an important role of SSTR3 on tumor shrinkage. The low affinity of LAN and OCT for this SSTR subtype could be compensated by its high expression in this GH-secreting pituitary macroadenoma.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf03347378", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088396", 
        "issn": [
          "0391-4097", 
          "1720-8386"
        ], 
        "name": "Journal of Endocrinological Investigation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "name": "Dissociation between tumor shrinkage and hormonal response during somatostatin analog treatment in an acromegalic patient: Preferential expression of somatostatin receptor subtype 3", 
    "pagination": "826-830", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2acae7e357d1776520fe49a4be749dd5e2ee17f93d5ee77fe22881a78aa249a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17114915"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806594"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf03347378"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008982520"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf03347378", 
      "https://app.dimensions.ai/details/publication/pub.1008982520"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2FBF03347378"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf03347378'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf03347378'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf03347378'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf03347378'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      21 PREDICATES      68 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf03347378 schema:about N2550a52fa1fc4ddca955dad68218ea20
2 N28c958c021ae40b293096574666355db
3 N5cf2266dea5a4ef382d8dd659cbe9bf2
4 N6d2027e18cd44a12ba689e11decc9ced
5 N9c234b6054664a0289a0beb5679aa859
6 N9dfd047c024a407d965f3d209728ae23
7 Nac1d6b50b5d04d0091b3ebc93340167c
8 Nb5d0e0ac6f514c459a58d02bda12ad0d
9 Nd306e84695d64bc6925c0e4c1ff5e3f0
10 Nd482e990a08843bbbc04522489200688
11 Nd4b0ee5858fd4eb489828b9ea477c6ce
12 Nd9be93b61df74bacbaef2d1894c03c21
13 Ne5f935e37aff45c0a7196fbee0d444c1
14 Nf2767d768f8240c8b8996f18f312f969
15 Nfac700569da447849f4b54c7dacfe933
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N4b4e4e46076941789c5c34757674f461
19 schema:citation sg:pub.10.1038/labinvest.3700303
20 sg:pub.10.1186/1472-6750-3-18
21 https://app.dimensions.ai/details/publication/pub.1082977090
22 https://app.dimensions.ai/details/publication/pub.1083181356
23 https://doi.org/10.1006/frne.1999.0183
24 https://doi.org/10.1016/0024-3205(95)02082-t
25 https://doi.org/10.1016/s0026-0495(96)90072-4
26 https://doi.org/10.1016/s0026-0495(96)90085-2
27 https://doi.org/10.1016/s0889-8529(05)70062-1
28 https://doi.org/10.1046/j.1365-2826.2003.01077.x
29 https://doi.org/10.1073/pnas.0136771100
30 https://doi.org/10.1111/j.1365-2265.2005.02317.x
31 https://doi.org/10.1159/000047824
32 https://doi.org/10.1210/endo.135.6.7988476
33 https://doi.org/10.1210/jc.2002-021825
34 https://doi.org/10.1210/jc.2003-030303
35 https://doi.org/10.1210/jc.2004-1093
36 https://doi.org/10.1210/jc.2005-0633
37 https://doi.org/10.1210/jc.83.8.2646
38 https://doi.org/10.1210/jc.85.2.526
39 https://doi.org/10.1210/jc.85.2.781
40 https://doi.org/10.1210/jc.86.7.2976
41 https://doi.org/10.1210/mend.10.12.8961277
42 https://doi.org/10.1210/mend.11.11.0016
43 schema:datePublished 2006-10
44 schema:datePublishedReg 2006-10-01
45 schema:description INTRODUCTION: About a third of acromegalic patients is resistant to available SS analogs (SA), octreotide (OCT) and lanreotide (LAN). Such resistance is related to reduction of SS receptor (SSTR) density or to a different expression of SSTR subtypes. There are 5 known SSTR subtypes. SSTR2 and SSTR5 are usually expressed in GH-secreting pituitary tumors, and both SA bind preferentially to SSTR2 and, to a lesser extent, to SSTR5. We herein describe an acromegalic patient who presented impressive tumor shrinkage without hormonal normalization during primary therapy with SA. MATERIAL AND METHODS: This 23-yr-old male acromegalic patient was treated with slow-release LAN (LAN-SR), 30 mg every 10 days for six months, followed by OCT-LAR, 30 mg every 28 days for an additional six months with a 75% tumor volume reduction but without GH and IGF-I normalization. Subsequently, he underwent pituitary surgery and expression of SSTR in the removed tumor was performed by real time RT-PCR by the 2-deltaCt method, using GAPDH as internal control. All PCR products were confirmed by automated sequencing. RESULTS: SSTR expression revealed an unusual profile, with almost exclusively expression of SSTR3. CONCLUSIONS: These unusual clinical and receptor subtypes profile suggest an important role of SSTR3 on tumor shrinkage. The low affinity of LAN and OCT for this SSTR subtype could be compensated by its high expression in this GH-secreting pituitary macroadenoma.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf N1bc5c481f5d545feba6e10d641d4a02a
50 N4e9041b9d6aa481e8ff04b42d0359cff
51 sg:journal.1088396
52 schema:name Dissociation between tumor shrinkage and hormonal response during somatostatin analog treatment in an acromegalic patient: Preferential expression of somatostatin receptor subtype 3
53 schema:pagination 826-830
54 schema:productId N0366a81f8c97442c9c3eece66b488ae4
55 N5c92bff0d8bc4b0fabf5d0f872625c3c
56 N98f28c0ddace443db989373528536785
57 Na435b44b527948fb8adfb14d549417dd
58 Nb08f847cac5b4f5494bc819b8def4e7e
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008982520
60 https://doi.org/10.1007/bf03347378
61 schema:sdDatePublished 2019-04-11T00:15
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher Nd520deb8c9564979b8c150242f0c2a91
64 schema:url http://link.springer.com/10.1007%2FBF03347378
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N0366a81f8c97442c9c3eece66b488ae4 schema:name readcube_id
69 schema:value 2acae7e357d1776520fe49a4be749dd5e2ee17f93d5ee77fe22881a78aa249a0
70 rdf:type schema:PropertyValue
71 N184db9ca24df4a2fab6455886e85cdd5 rdf:first sg:person.01234624673.27
72 rdf:rest N4a238a1eefd846d8931d150e1951be92
73 N1bc5c481f5d545feba6e10d641d4a02a schema:issueNumber 9
74 rdf:type schema:PublicationIssue
75 N2550a52fa1fc4ddca955dad68218ea20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Acromegaly
77 rdf:type schema:DefinedTerm
78 N28c958c021ae40b293096574666355db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Radiography
80 rdf:type schema:DefinedTerm
81 N4a238a1eefd846d8931d150e1951be92 rdf:first sg:person.01330775246.60
82 rdf:rest Nad25ae95478041ea8e3661e06b9c1ed3
83 N4b4e4e46076941789c5c34757674f461 rdf:first sg:person.01330730262.50
84 rdf:rest N184db9ca24df4a2fab6455886e85cdd5
85 N4e9041b9d6aa481e8ff04b42d0359cff schema:volumeNumber 29
86 rdf:type schema:PublicationVolume
87 N5c92bff0d8bc4b0fabf5d0f872625c3c schema:name nlm_unique_id
88 schema:value 7806594
89 rdf:type schema:PropertyValue
90 N5cf2266dea5a4ef382d8dd659cbe9bf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Growth Hormone-Secreting Pituitary Adenoma
92 rdf:type schema:DefinedTerm
93 N6d2027e18cd44a12ba689e11decc9ced schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Pituitary Gland
95 rdf:type schema:DefinedTerm
96 N893cbc4f5e6d4373869a5771a5d144b7 rdf:first sg:person.0701547225.12
97 rdf:rest Ne4e81d0c085b487ca80421d0f8a67c11
98 N98f28c0ddace443db989373528536785 schema:name dimensions_id
99 schema:value pub.1008982520
100 rdf:type schema:PropertyValue
101 N9c234b6054664a0289a0beb5679aa859 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Receptors, Somatostatin
103 rdf:type schema:DefinedTerm
104 N9dfd047c024a407d965f3d209728ae23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Gene Expression
106 rdf:type schema:DefinedTerm
107 Na435b44b527948fb8adfb14d549417dd schema:name doi
108 schema:value 10.1007/bf03347378
109 rdf:type schema:PropertyValue
110 Nac1d6b50b5d04d0091b3ebc93340167c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Remission Induction
112 rdf:type schema:DefinedTerm
113 Nad25ae95478041ea8e3661e06b9c1ed3 rdf:first sg:person.01172355325.25
114 rdf:rest N893cbc4f5e6d4373869a5771a5d144b7
115 Nb08f847cac5b4f5494bc819b8def4e7e schema:name pubmed_id
116 schema:value 17114915
117 rdf:type schema:PropertyValue
118 Nb5d0e0ac6f514c459a58d02bda12ad0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Humans
120 rdf:type schema:DefinedTerm
121 Nd306e84695d64bc6925c0e4c1ff5e3f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Insulin-Like Growth Factor I
123 rdf:type schema:DefinedTerm
124 Nd482e990a08843bbbc04522489200688 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Male
126 rdf:type schema:DefinedTerm
127 Nd4b0ee5858fd4eb489828b9ea477c6ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Somatostatin
129 rdf:type schema:DefinedTerm
130 Nd520deb8c9564979b8c150242f0c2a91 schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 Nd9be93b61df74bacbaef2d1894c03c21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Human Growth Hormone
134 rdf:type schema:DefinedTerm
135 Ne4e81d0c085b487ca80421d0f8a67c11 rdf:first sg:person.0701373340.99
136 rdf:rest rdf:nil
137 Ne5f935e37aff45c0a7196fbee0d444c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Adult
139 rdf:type schema:DefinedTerm
140 Nf2767d768f8240c8b8996f18f312f969 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Peptides, Cyclic
142 rdf:type schema:DefinedTerm
143 Nfac700569da447849f4b54c7dacfe933 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Octreotide
145 rdf:type schema:DefinedTerm
146 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
147 schema:name Medical and Health Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
150 schema:name Clinical Sciences
151 rdf:type schema:DefinedTerm
152 sg:journal.1088396 schema:issn 0391-4097
153 1720-8386
154 schema:name Journal of Endocrinological Investigation
155 rdf:type schema:Periodical
156 sg:person.01172355325.25 schema:affiliation https://www.grid.ac/institutes/grid.11899.38
157 schema:familyName Giorgi
158 schema:givenName R. R.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172355325.25
160 rdf:type schema:Person
161 sg:person.01234624673.27 schema:affiliation https://www.grid.ac/institutes/grid.11899.38
162 schema:familyName Pinto
163 schema:givenName E. M.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234624673.27
165 rdf:type schema:Person
166 sg:person.01330730262.50 schema:affiliation https://www.grid.ac/institutes/grid.11899.38
167 schema:familyName Casarini
168 schema:givenName A. P. M.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330730262.50
170 rdf:type schema:Person
171 sg:person.01330775246.60 schema:affiliation https://www.grid.ac/institutes/grid.11899.38
172 schema:familyName Jallad
173 schema:givenName R. S.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330775246.60
175 rdf:type schema:Person
176 sg:person.0701373340.99 schema:affiliation https://www.grid.ac/institutes/grid.11899.38
177 schema:familyName Bronstein
178 schema:givenName M. D.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701373340.99
180 rdf:type schema:Person
181 sg:person.0701547225.12 schema:affiliation https://www.grid.ac/institutes/grid.11899.38
182 schema:familyName Giannella-Neto
183 schema:givenName D.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701547225.12
185 rdf:type schema:Person
186 sg:pub.10.1038/labinvest.3700303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035012001
187 https://doi.org/10.1038/labinvest.3700303
188 rdf:type schema:CreativeWork
189 sg:pub.10.1186/1472-6750-3-18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003492027
190 https://doi.org/10.1186/1472-6750-3-18
191 rdf:type schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1082977090 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1083181356 schema:CreativeWork
194 https://doi.org/10.1006/frne.1999.0183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043191743
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/0024-3205(95)02082-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1036017807
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s0026-0495(96)90072-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032023135
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/s0026-0495(96)90085-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015966070
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/s0889-8529(05)70062-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031163682
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1046/j.1365-2826.2003.01077.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023958773
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1073/pnas.0136771100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050804370
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1111/j.1365-2265.2005.02317.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032107093
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1159/000047824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034849820
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1210/endo.135.6.7988476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064279666
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1210/jc.2002-021825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286547
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1210/jc.2003-030303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286795
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1210/jc.2004-1093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041330747
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1210/jc.2005-0633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288451
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1210/jc.83.8.2646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064300335
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1210/jc.85.2.526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064301229
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1210/jc.85.2.781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064301265
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1210/jc.86.7.2976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064302005
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1210/mend.10.12.8961277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331247
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1210/mend.11.11.0016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331382
233 rdf:type schema:CreativeWork
234 https://www.grid.ac/institutes/grid.11899.38 schema:alternateName University of Sao Paulo
235 schema:name Endocrine and Development Unit Laboratory of Hormone and Molecular Genetics (LIM42), University of Sao Paulo Medical School, Sao Paulo, Brazil
236 Laboratory Cellular and Molecular Endocrinology (LIM25), University of Sao Paulo Medical School, Sao Paulo, Brazil
237 Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital of Clínicas, University of Sao Paulo Medical School, Sao Paulo, Brazil
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...