Increased level of thyroglobulin mRNA in a human familial goiter View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-02

AUTHORS

A. Monticelli, V. E. Avvedimento, A. Mariano, C. Marcocci, L. Chiovato, G. F. Fenzi, A. Pinchera, S. Varrone

ABSTRACT

Thyroglobulin (Tg) and its specific mRNA were analyzed in the thyroid gland of two cases of familial goiter. A three-fold increase in the level of stable protein and functional Tg mRNA was found in the goiter of one of the two patients in whom a desiodase defect was demonstrated. Normal concentrations of both Tg and its mRNA were found in the other goiter in which no enzymatic defect could be shown. Our results suggest that the increase of Tg mRNA levels found in the goiter with a desiodase defect was due to a chronic stimulation of the gland by TSH. More... »

PAGES

59-63

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03347155

DOI

http://dx.doi.org/10.1007/bf03347155

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037557834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3110253


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