Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) protein View Full Text


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Article Info

DATE

2011-03

AUTHORS

P. Agretti, A. Dimida, G. De Marco, E. Ferrarini, J. C. Rodrìguez González, F. Santini, P. Vitti, A. Pinchera, M. Tonacchera

ABSTRACT

Background: Thyroid gland is highly dependent on dietary intake of iodine for normal function, so it is particularly subjected to “endocrine disruptor” action. The human sodium/iodide symporter (hNIS) is an integral plasma membrane glycoprotein mediating the active transport of iodide into thyroid follicular cells, a crucial step for thyroid hormone biosynthesis. Beyond to perchlorate and thyocianate ions a few other inhibitors of iodide uptake have been described. Aim: The aim of this study was to investigate if 10 substances usually used as drugs in clinical practice were able to inhibit NIS-mediated iodide uptake in vitro. Materials and methods: A CHO cell line stably expressing hNIS was used to test any inhibition of NIS-mediated iodide uptake exerted by drugs. Perchlorate and thyocianate ions were used as positive controls. Results: None of the analyzed substances was able to significantly inhibit iodide uptake in our system. As we expected, perchlorate and thyocianate ions were able to inhibit iodide uptake in a dose-dependent manner. Conclusions: In conclusion, we carried out an in vitro assay to evaluate the potential inhibitory effect of common drugs on NIS-mediated iodide uptake by using CHO-hNIS cells. None of the analyzed substances was able to inhibit iodide uptake; only perchlorate and thyocianate were able to inhibit iodide uptake in a dose-dependent manner. More... »

PAGES

170-174

References to SciGraph publications

  • 1998-04. The Na+/I− Symporter (NIS): Recent Advances in JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
  • 1986. Iodine-Sufficient Goiter and Autoimmune Thyroiditis: The Kentucky and Colombian Experience in FRONTIERS IN THYROIDOLOGY
  • 2003-10. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 1997-12. The Na+-I– cotransporter of the thyroid: characterisation of new inhibitors in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
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    URI

    http://scigraph.springernature.com/pub.10.1007/bf03347061

    DOI

    http://dx.doi.org/10.1007/bf03347061

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036937973


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