Ontology type: schema:ScholarlyArticle Open Access: True
2008-10
AUTHORSF. Cetani, E. Pardi, E. Ambrogini, C. Banti, P. Viacava, S. Borsari, J. P. Bilezikian, A. Pinchera, C. Marcocci
ABSTRACTHRPT2 and parafibromin studies improved the diagnostic accuracy in two patients with primary hyperparathyroidism (PHPT) referred to us after surgery, in whom the clinical data were at variance with the pathological diagnosis of adenoma and carcinoma, respectively. Patients were referred to us after parathyroidectomy. Patient #1 had had a 1.5-cm tumor easily removed with a histological diagnosis of parathyroid carcinoma and normocalcemia for 2 years. Re-examination of the histology showed no cardinal signs of parathyroid cancer. Patient #2, with severe PHPT, had had the removal of a 3.5-cm tumor described histologically as adenoma. Ten years later PHPT recurred and persisted despite removal of two mildly enlarged parathyroid glands that were histologically normal. Re-review of the initial histology showed a trabecular pattern, fibrous bands, and atypical mitoses, suggesting an atypical adenoma. Because of the suspicion that case #1 could be an atypical adenoma and case #2 a carcinoma further molecular studies were performed. No HRPT2 and parafibromin abnormalities were identified in patient #1, strongly indicating a benign lesion. In patient #2, an HRPT2 germline mutation was found (E115X in exon 4) and associated with no parafibromin staining. These data, together with the clinical features, supported the suspicion of a parathyroid carcinoma that was confirmed by histological examination of further slides of the tumor, showing capsular and vascular invasion. A lung 1.5-cm nodule detected by computed tomography was excised. Histology showed a metastasis of parathyroid carcinoma. HRPT2 gene studies improved the diagnostic accuracy in 2 parathyroid tumors that are of uncertain type. More... »
PAGES900-904
http://scigraph.springernature.com/pub.10.1007/bf03346439
DOIhttp://dx.doi.org/10.1007/bf03346439
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1032425093
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/19092296
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adenoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hyperparathyroidism, Primary",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Parathyroid Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Suppressor Proteins",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Departments of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Cetani",
"givenName": "F.",
"id": "sg:person.01015044562.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015044562.92"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Departments of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Pardi",
"givenName": "E.",
"id": "sg:person.01363263354.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363263354.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Departments of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Ambrogini",
"givenName": "E.",
"id": "sg:person.0637657254.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637657254.61"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Departments of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Banti",
"givenName": "C.",
"id": "sg:person.0705772454.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705772454.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Oncology (Section of Pathology), University of Pisa, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Viacava",
"givenName": "P.",
"id": "sg:person.01256032251.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256032251.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Departments of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Borsari",
"givenName": "S.",
"id": "sg:person.01176105400.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176105400.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Columbia University",
"id": "https://www.grid.ac/institutes/grid.21729.3f",
"name": [
"Department of Medicine and Pharmacology, Columbia University College of Physicians & Surgeons, 10032, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Bilezikian",
"givenName": "J. P.",
"id": "sg:person.01001332233.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001332233.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Departments of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Pinchera",
"givenName": "A.",
"id": "sg:person.01344402654.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344402654.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Departments of Endocrinology, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Marcocci",
"givenName": "C.",
"id": "sg:person.01003046263.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003046263.82"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1136/jmg.40.9.657",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002179256"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(197303)31:3<600::aid-cncr2820310316>3.0.co;2-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002393582"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf03347291",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004588470",
"https://doi.org/10.1007/bf03347291"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.pas.0000209827.39477.4f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005445922"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.pas.0000209827.39477.4f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005445922"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1359/jbmr.060702",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007375548"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199403173301105",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017191110"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s002689900567",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024370463",
"https://doi.org/10.1007/s002689900567"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2265.2004.01954.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026228254"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa031237",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039018216"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-04-0493",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040891752"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.pap.0000151319.42376.d4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046599670"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.pap.0000151319.42376.d4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046599670"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1677/erc-07-0021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050299893"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1530/eje-06-0720",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053077826"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2004-0294",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064287721"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2005-1239",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064288628"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jcem.86.2.7207",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064324142"
],
"type": "CreativeWork"
}
],
"datePublished": "2008-10",
"datePublishedReg": "2008-10-01",
"description": "HRPT2 and parafibromin studies improved the diagnostic accuracy in two patients with primary hyperparathyroidism (PHPT) referred to us after surgery, in whom the clinical data were at variance with the pathological diagnosis of adenoma and carcinoma, respectively. Patients were referred to us after parathyroidectomy. Patient #1 had had a 1.5-cm tumor easily removed with a histological diagnosis of parathyroid carcinoma and normocalcemia for 2 years. Re-examination of the histology showed no cardinal signs of parathyroid cancer. Patient #2, with severe PHPT, had had the removal of a 3.5-cm tumor described histologically as adenoma. Ten years later PHPT recurred and persisted despite removal of two mildly enlarged parathyroid glands that were histologically normal. Re-review of the initial histology showed a trabecular pattern, fibrous bands, and atypical mitoses, suggesting an atypical adenoma. Because of the suspicion that case #1 could be an atypical adenoma and case #2 a carcinoma further molecular studies were performed. No HRPT2 and parafibromin abnormalities were identified in patient #1, strongly indicating a benign lesion. In patient #2, an HRPT2 germline mutation was found (E115X in exon 4) and associated with no parafibromin staining. These data, together with the clinical features, supported the suspicion of a parathyroid carcinoma that was confirmed by histological examination of further slides of the tumor, showing capsular and vascular invasion. A lung 1.5-cm nodule detected by computed tomography was excised. Histology showed a metastasis of parathyroid carcinoma. HRPT2 gene studies improved the diagnostic accuracy in 2 parathyroid tumors that are of uncertain type.",
"genre": "research_article",
"id": "sg:pub.10.1007/bf03346439",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2492588",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1088396",
"issn": [
"0391-4097",
"1720-8386"
],
"name": "Journal of Endocrinological Investigation",
"type": "Periodical"
},
{
"issueNumber": "10",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "31"
}
],
"name": "Hyperparathyroidism 2 gene (HRPT2, CDC73) and parafibromin studies in two patients with primary hyperparathyroidism and uncertain pathological assessment",
"pagination": "900-904",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"9a77f7e099fc4a1d177e8619bbda2d4fe09c24acab22f3bcae5664363bb0114a"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"19092296"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"7806594"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/bf03346439"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1032425093"
]
}
],
"sameAs": [
"https://doi.org/10.1007/bf03346439",
"https://app.dimensions.ai/details/publication/pub.1032425093"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:47",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000513.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2FBF03346439"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf03346439'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf03346439'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf03346439'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf03346439'
This table displays all metadata directly associated to this object as RDF triples.
213 TRIPLES
21 PREDICATES
53 URIs
29 LITERALS
17 BLANK NODES