Ontology type: schema:ScholarlyArticle
2008-08
AUTHORSF. Y. Miasaki, A. Vivaldi, R. Ciampi, L. Agate, P. Collecchi, A. Capodanno, A. Pinchera, R. Elisei
ABSTRACTThe treatment of both undifferentiated and de-differentiated thyroid tumors, which are unresponsive to radioiodine, represents one of the biggest challenges for thyroidologists. The aim of the present study was to investigate in vitro the methylation status of retinoic acid receptors (RAR)beta2 promoter and the effect of the demethylating agent 5-aza-2'-deoxycytidine (5-Aza-CdR) on 5 human thyroid cancer cell lines. The methylation status of RARbeta2 promoter was analyzed by methylation-specific PCR. The effect of 5-Aza-CdR on cell growth and apoptosis was evaluated by cell counting, enzymelinked immunosorbent assay tests and fluorescence-activated cell sorting analysis, while the effect on the expression of RAR and thyroid-specific genes was measured by qualitative and quantitative RT-PCR. Methylation of RARbeta2 promoter was present only in ARO cells. 5-Aza-CdR determined growth inhibition in all cell lines, probably due to apoptosis in WRO, NPA, and ARO cells, and to inhibition of DNA synthesis in TT cells. Treatment with 5-Aza-CdR induced the expression of RARbeta mRNA in ARO and FRO cells, a slight increase of the expression of Tg, TPO and thyroid trancription factor 1 (TTF-1) mRNA and the new expression of low levels of NIS in TT cells. A significant increase of TTF-1 mRNA in FRO cells was also observed. In this study we demonstrated that RARbeta2 promoter was methylated in ARO cell line. However, the 5-Aza-CdR treatment induced RARbetamRNA expression not only in ARO but also in FRO and TT cell lines, whose RARbeta2 promoter was unmethylated. A significant reduction of cell growth, but not cell re-differentiation, was also observed after 5-Aza-CdR treatment. More... »
PAGES724-730
http://scigraph.springernature.com/pub.10.1007/bf03346422
DOIhttp://dx.doi.org/10.1007/bf03346422
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1027818843
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18852534
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antimetabolites, Antineoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Azacitidine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Proliferation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Methylation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation, Neoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Organ Specificity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Promoter Regions, Genetic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Retinoic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retinoic Acid Receptor alpha",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thyroid Gland",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thyroid Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transfection",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa no 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Miasaki",
"givenName": "F. Y.",
"id": "sg:person.01217263613.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217263613.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa no 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Vivaldi",
"givenName": "A.",
"id": "sg:person.0675072442.93",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675072442.93"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa no 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Ciampi",
"givenName": "R.",
"id": "sg:person.0727121223.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727121223.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa no 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Agate",
"givenName": "L.",
"id": "sg:person.0737401543.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737401543.39"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Oncology, Division of Pathology I, Italy"
],
"type": "Organization"
},
"familyName": "Collecchi",
"givenName": "P.",
"id": "sg:person.0640136321.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640136321.78"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Oncology, Division of Pathology I, Italy"
],
"type": "Organization"
},
"familyName": "Capodanno",
"givenName": "A.",
"id": "sg:person.01250755616.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250755616.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa no 2, 56124, Pisa, Italy",
"AMBISEN Center, High Technology Center for the Study of the Environmental Damage of the Endocrine and Nervous Systems, University of Pisa, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Pinchera",
"givenName": "A.",
"id": "sg:person.01344402654.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344402654.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pisa",
"id": "https://www.grid.ac/institutes/grid.5395.a",
"name": [
"Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa no 2, 56124, Pisa, Italy"
],
"type": "Organization"
},
"familyName": "Elisei",
"givenName": "R.",
"id": "sg:person.013417777464.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013417777464.53"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf02991580",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005067424",
"https://doi.org/10.1007/bf02991580"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s002800050740",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006017120",
"https://doi.org/10.1007/s002800050740"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/dji371",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007107318"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19940801)74:3<928::aid-cncr2820740321>3.0.co;2-e",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010323727"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.seminoncol.2005.07.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011170817"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.seminoncol.2005.07.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011170817"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/002215540305100703",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012072329"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/002215540305100703",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012072329"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1634/theoncologist.12-1-20",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019986619"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1204750",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022567684",
"https://doi.org/10.1038/sj.onc.1204750"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1204750",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022567684",
"https://doi.org/10.1038/sj.onc.1204750"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg962",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027003214",
"https://doi.org/10.1038/nrg962"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg962",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027003214",
"https://doi.org/10.1038/nrg962"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0002-9440(10)63966-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028096679"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.seminoncol.2005.07.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028788148"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.seminoncol.2005.07.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028788148"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.canlet.2004.06.044",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029553032"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/labinvest.3780202",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030018741",
"https://doi.org/10.1038/labinvest.3780202"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/labinvest.3780202",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030018741",
"https://doi.org/10.1038/labinvest.3780202"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.93.18.9821",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030175469"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-05-0218",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030954071"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199801293380506",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032016310"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncponc0354",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034769071",
"https://doi.org/10.1038/ncponc0354"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncponc0354",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034769071",
"https://doi.org/10.1038/ncponc0354"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.25.23.10591-10603.2005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035893649"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmra023075",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035903614"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19830915)52:6<1053::aid-cncr2820520621>3.0.co;2-q",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037406066"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203456",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039422578",
"https://doi.org/10.1038/sj.onc.1203456"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203456",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039422578",
"https://doi.org/10.1038/sj.onc.1203456"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.canlet.2005.01.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042404487"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0046-8177(00)80255-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043062586"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(20000701)89:1<202::aid-cncr27>3.0.co;2-a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045394739"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1209054",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046853728",
"https://doi.org/10.1038/sj.onc.1209054"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1209054",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046853728",
"https://doi.org/10.1038/sj.onc.1209054"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1209508",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048693720",
"https://doi.org/10.1038/sj.onc.1209508"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1209508",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048693720",
"https://doi.org/10.1038/sj.onc.1209508"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1207381",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049969277",
"https://doi.org/10.1038/sj.onc.1207381"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1207381",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049969277",
"https://doi.org/10.1038/sj.onc.1207381"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/92.10.826",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051189282"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg816",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053491434",
"https://doi.org/10.1038/nrg816"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg816",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053491434",
"https://doi.org/10.1038/nrg816"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2004.07.151",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064204177"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/edrv-15-1-61",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064238062"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/en.2006-0927",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064248218"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2003-030770",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064287001"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2004-0969",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064287923"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2004-2140",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064288154"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2005-2480",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064288930"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.84.7.2449",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064300883"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jcem.78.4.8157713",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064318640"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075042830",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075279959",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fasebj.10.9.8801174",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082959747"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083180899",
"type": "CreativeWork"
}
],
"datePublished": "2008-08",
"datePublishedReg": "2008-08-01",
"description": "The treatment of both undifferentiated and de-differentiated thyroid tumors, which are unresponsive to radioiodine, represents one of the biggest challenges for thyroidologists. The aim of the present study was to investigate in vitro the methylation status of retinoic acid receptors (RAR)beta2 promoter and the effect of the demethylating agent 5-aza-2'-deoxycytidine (5-Aza-CdR) on 5 human thyroid cancer cell lines. The methylation status of RARbeta2 promoter was analyzed by methylation-specific PCR. The effect of 5-Aza-CdR on cell growth and apoptosis was evaluated by cell counting, enzymelinked immunosorbent assay tests and fluorescence-activated cell sorting analysis, while the effect on the expression of RAR and thyroid-specific genes was measured by qualitative and quantitative RT-PCR. Methylation of RARbeta2 promoter was present only in ARO cells. 5-Aza-CdR determined growth inhibition in all cell lines, probably due to apoptosis in WRO, NPA, and ARO cells, and to inhibition of DNA synthesis in TT cells. Treatment with 5-Aza-CdR induced the expression of RARbeta mRNA in ARO and FRO cells, a slight increase of the expression of Tg, TPO and thyroid trancription factor 1 (TTF-1) mRNA and the new expression of low levels of NIS in TT cells. A significant increase of TTF-1 mRNA in FRO cells was also observed. In this study we demonstrated that RARbeta2 promoter was methylated in ARO cell line. However, the 5-Aza-CdR treatment induced RARbetamRNA expression not only in ARO but also in FRO and TT cell lines, whose RARbeta2 promoter was unmethylated. A significant reduction of cell growth, but not cell re-differentiation, was also observed after 5-Aza-CdR treatment.",
"genre": "research_article",
"id": "sg:pub.10.1007/bf03346422",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1088396",
"issn": [
"0391-4097",
"1720-8386"
],
"name": "Journal of Endocrinological Investigation",
"type": "Periodical"
},
{
"issueNumber": "8",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "31"
}
],
"name": "Retinoic acid receptor \u03b22 re-expression and growth inhibition in thyroid carcinoma cell lines after 5-aza-2\u2032-deoxycytidine treatment",
"pagination": "724-730",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"848576b2586c45928405dc5559f3f20e46d50f9601aa0437b8a1e34c22d348f8"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"18852534"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"7806594"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/bf03346422"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1027818843"
]
}
],
"sameAs": [
"https://doi.org/10.1007/bf03346422",
"https://app.dimensions.ai/details/publication/pub.1027818843"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T15:52",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000513.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2FBF03346422"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf03346422'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf03346422'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf03346422'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf03346422'
This table displays all metadata directly associated to this object as RDF triples.
317 TRIPLES
21 PREDICATES
86 URIs
36 LITERALS
24 BLANK NODES