Intense 18-fluorodeoxyglucose uptake by the thymus on PET scan does not necessarily herald recurrence of thyroid carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-02

AUTHORS

V. Godart, B. Weynand, E. Coche, P. De Nayer, C. Daumerie

ABSTRACT

This is the first report of intense fluorodeoxyglucose positron emission tomography (FDG-PET) uptake secondary to thymic hyperplasia during follow-up for thyroid carcinoma. A 36-yr-old woman underwent thyroidectomy for a papillary carcinoma measuring 4 cm in diameter. After two doses of radioiodine, thyroglobulin (Tg) remained detectable following recombinant human TSH (rhTSH) stimulation. A whole body scan (WBS) was negative. On computed tomography (CT) scan, a slightly lobulated thymus was visualized. PET scan showed intense thymic uptake. Following resection, anatomo-pathological analysis showed homogenous hyperplastic thymic gland without neoplastic cells. Two months later, under levothyroxin (L-T4) substitution, Tg was no longer detectable and PET scanning did not show any 18-FDG uptake. This observation suggests that thymic FDG uptake does not necessarily herald recurrence of thyroid carcinoma and must be interpreted with caution in such a setting. Other conditions associated with abnormal uptake by hyperplastic thymus must also be envisaged. More... »

PAGES

1024-1028

References to SciGraph publications

  • 1998-04. Histological verification of positive fluorine-18 fluorodeoxyglucose findings in patients with differentiated thyroid cancer in LANGENBECK'S ARCHIVES OF SURGERY
  • 1993-07. Mediastinal uptake of 131-I in patients with thyroid cancer: may it be referred to normal thymus? in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2004-06. The clinical relevance of thymic fluorodeoxyglucose uptake in pediatric patients after chemotherapy in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2000-04. How frequently is the thymus seen on whole-body iodine-131 diagnostic and post-treatment scans? in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2000-04. The human sodium-iodine symporter (NIS) as a key for specific thymic iodine-131 uptake in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1998-06. Therapeutic implications of thymic uptake of radioiodine in thyroid carcinoma in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf03345343

    DOI

    http://dx.doi.org/10.1007/bf03345343

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026533368

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16483183


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