Ontology type: schema:ScholarlyArticle
2008-06
AUTHORSMaria Antonietta Altea, Eleonora Sisti, Aldo Pinchera, Claudio Marcocci, Michele Marinò
ABSTRACTI glucocorticoidi (GC) per via endovenosa (ev) rappresentano lo strumento terapeutico più diffuso ed efficace per l’oftalmopatia basedowiana (OB). Tuttavia, l’osservazione di alcuni casi di danno epatico acuto (DEA) durante o dopo terapia con GC ev ha sollevato importanti interrogativi sulla sicurezza di questo tipo di terapia e sull’opportunità di effettuarla indiscriminatamente in tutti i pazienti con OB in cui sarebbe indicata. Un importante aspetto da considerare è se l’osservazione di DEA durante o dopo terapia con GC ev sia un evento casuale, o da mettere effettivamente in relazione con la terapia. A tale proposito, non esistono studi epidemiologici che consentano di confrontare la frequenza del DEA tra pazienti trattati con GC ev e popolazione generale. In questo articolo abbiamo analizzato in maniera retrospettiva i casi di DEA riportati in letteratura e gli studi su casistica disponibili, allo scopo di valutarne la frequenza e individuarne i possibili predisponenti. More... »
PAGES48-53
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