The free radical hypothesis of aging: An appraisal of the current status View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-02

AUTHORS

R. S. Sohal

ABSTRACT

The objective of this review article is to assess the current status of the predictions of the free radical hypothesis of aging, highlighting some of the controversies surrounding the previous assumptions. Topics for discussion include: metabolic rate and aging, oxidative stress and molecular damage during aging, antioxidants and aging, antioxidant defenses and life spans of different species, and pro-oxidant generation and aging. On the basis of currently available evidence, it is concluded that the free radical hypothesis has neither been proven nor disproven. Some of the earlier assumptions such as that antioxidant intake increases life span, or antioxidant defenses decline with age, or antioxidant defenses are positively correlated with life spans of different species, or that longer life spans are associated with lower autoxidizability, are not clearly supportable. Similarly, the assumption that oxygen free radicals govern the rate of aging via the infliction of molecular damage lacks compelling support. Enough information to lift the free radical hypothesis above the level of speculation has not yet been amassed. Clearly, further studies, some of which specifically focus on disproving this hypothesis, are needed to confirm its veracity. (Aging Clin. Exp. Res. 5: 3–17, 1993) More... »

PAGES

3-17

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03324120

DOI

http://dx.doi.org/10.1007/bf03324120

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044785744

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8386942


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology and Cognitive Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1702", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cognitive Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Free Radicals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Life Expectancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidation-Reduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Superoxides", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biological Sciences, Southern Methodist University, 75275-0376, Dallas, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.263864.d", 
          "name": [
            "Department of Biological Sciences, Southern Methodist University, 75275-0376, Dallas, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sohal", 
        "givenName": "R. S.", 
        "id": "sg:person.010622315454.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010622315454.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/196454a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013779012", 
          "https://doi.org/10.1038/196454a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/199400a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014985961", 
          "https://doi.org/10.1038/199400a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-70853-4_3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037613487", 
          "https://doi.org/10.1007/978-3-642-70853-4_3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4612-5890-2_12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021344939", 
          "https://doi.org/10.1007/978-1-4612-5890-2_12"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1993-02", 
    "datePublishedReg": "1993-02-01", 
    "description": "The objective of this review article is to assess the current status of the predictions of the free radical hypothesis of aging, highlighting some of the controversies surrounding the previous assumptions. Topics for discussion include: metabolic rate and aging, oxidative stress and molecular damage during aging, antioxidants and aging, antioxidant defenses and life spans of different species, and pro-oxidant generation and aging. On the basis of currently available evidence, it is concluded that the free radical hypothesis has neither been proven nor disproven. Some of the earlier assumptions such as that antioxidant intake increases life span, or antioxidant defenses decline with age, or antioxidant defenses are positively correlated with life spans of different species, or that longer life spans are associated with lower autoxidizability, are not clearly supportable. Similarly, the assumption that oxygen free radicals govern the rate of aging via the infliction of molecular damage lacks compelling support. Enough information to lift the free radical hypothesis above the level of speculation has not yet been amassed. Clearly, further studies, some of which specifically focus on disproving this hypothesis, are needed to confirm its veracity. (Aging Clin. Exp. Res. 5: 3\u201317, 1993)", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf03324120", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2445518", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2445373", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1030201", 
        "issn": [
          "1594-0667", 
          "1720-8319"
        ], 
        "name": "Aging Clinical and Experimental Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "molecular damage", 
      "different species", 
      "antioxidant defense", 
      "life span", 
      "free radical hypothesis", 
      "long life span", 
      "radical hypothesis", 
      "species", 
      "oxidative stress", 
      "defense", 
      "metabolic rate", 
      "compelling support", 
      "previous assumptions", 
      "hypothesis", 
      "autoxidizability", 
      "aging", 
      "current status", 
      "antioxidants", 
      "earlier assumptions", 
      "span", 
      "damage", 
      "free radicals", 
      "Further studies", 
      "stress", 
      "pro-oxidant generation", 
      "review article", 
      "basis", 
      "status", 
      "evidence", 
      "levels", 
      "generation", 
      "speculation", 
      "rate", 
      "available evidence", 
      "study", 
      "enough information", 
      "information", 
      "prediction", 
      "radicals", 
      "infliction", 
      "controversy", 
      "assumption", 
      "objective", 
      "support", 
      "topic", 
      "age", 
      "discussion", 
      "article", 
      "veracity", 
      "appraisal", 
      "level of speculation", 
      "lower autoxidizability"
    ], 
    "name": "The free radical hypothesis of aging: An appraisal of the current status", 
    "pagination": "3-17", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044785744"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf03324120"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8386942"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf03324120", 
      "https://app.dimensions.ai/details/publication/pub.1044785744"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_219.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf03324120"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf03324120'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf03324120'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf03324120'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf03324120'


 

This table displays all metadata directly associated to this object as RDF triples.

178 TRIPLES      22 PREDICATES      93 URIs      78 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf03324120 schema:about N1ce230ae9a534eed89a27917c243ef51
2 N59497f9eca994ec8a0a44823a3928ee7
3 N5a7db261b6e145f09bcd098690fbcfea
4 N5fb28b95a446490382be667fe6b278b6
5 N6bacb5f309434d2ca3416bb5cc64fc18
6 N99e94ce1ddd1451b844fe6bf98c9605a
7 Nccef79c18d5f4011aad8fcee66807c52
8 Nd7bd4199a56241978d3ad202bee07f73
9 anzsrc-for:11
10 anzsrc-for:1103
11 anzsrc-for:1117
12 anzsrc-for:17
13 anzsrc-for:1702
14 schema:author Na1b38375641b473984ed17481557d974
15 schema:citation sg:pub.10.1007/978-1-4612-5890-2_12
16 sg:pub.10.1007/978-3-642-70853-4_3
17 sg:pub.10.1038/196454a0
18 sg:pub.10.1038/199400a0
19 schema:datePublished 1993-02
20 schema:datePublishedReg 1993-02-01
21 schema:description The objective of this review article is to assess the current status of the predictions of the free radical hypothesis of aging, highlighting some of the controversies surrounding the previous assumptions. Topics for discussion include: metabolic rate and aging, oxidative stress and molecular damage during aging, antioxidants and aging, antioxidant defenses and life spans of different species, and pro-oxidant generation and aging. On the basis of currently available evidence, it is concluded that the free radical hypothesis has neither been proven nor disproven. Some of the earlier assumptions such as that antioxidant intake increases life span, or antioxidant defenses decline with age, or antioxidant defenses are positively correlated with life spans of different species, or that longer life spans are associated with lower autoxidizability, are not clearly supportable. Similarly, the assumption that oxygen free radicals govern the rate of aging via the infliction of molecular damage lacks compelling support. Enough information to lift the free radical hypothesis above the level of speculation has not yet been amassed. Clearly, further studies, some of which specifically focus on disproving this hypothesis, are needed to confirm its veracity. (Aging Clin. Exp. Res. 5: 3–17, 1993)
22 schema:genre article
23 schema:inLanguage en
24 schema:isAccessibleForFree false
25 schema:isPartOf N143fb30c838b46d298af80a7b3e18554
26 N4a27d5f18371432ab71f48f9db939fb5
27 sg:journal.1030201
28 schema:keywords Further studies
29 age
30 aging
31 antioxidant defense
32 antioxidants
33 appraisal
34 article
35 assumption
36 autoxidizability
37 available evidence
38 basis
39 compelling support
40 controversy
41 current status
42 damage
43 defense
44 different species
45 discussion
46 earlier assumptions
47 enough information
48 evidence
49 free radical hypothesis
50 free radicals
51 generation
52 hypothesis
53 infliction
54 information
55 level of speculation
56 levels
57 life span
58 long life span
59 lower autoxidizability
60 metabolic rate
61 molecular damage
62 objective
63 oxidative stress
64 prediction
65 previous assumptions
66 pro-oxidant generation
67 radical hypothesis
68 radicals
69 rate
70 review article
71 span
72 species
73 speculation
74 status
75 stress
76 study
77 support
78 topic
79 veracity
80 schema:name The free radical hypothesis of aging: An appraisal of the current status
81 schema:pagination 3-17
82 schema:productId N506b1d47138849218dd5792243fa279e
83 N721c5fee06b7450ba751974d6c4524c4
84 Nf5273988bf8941599dc91be28980bedd
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044785744
86 https://doi.org/10.1007/bf03324120
87 schema:sdDatePublished 2021-12-01T19:07
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher Nea52e52790a24175b117572daedc6e75
90 schema:url https://doi.org/10.1007/bf03324120
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N143fb30c838b46d298af80a7b3e18554 schema:volumeNumber 5
95 rdf:type schema:PublicationVolume
96 N1ce230ae9a534eed89a27917c243ef51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Life Expectancy
98 rdf:type schema:DefinedTerm
99 N4a27d5f18371432ab71f48f9db939fb5 schema:issueNumber 1
100 rdf:type schema:PublicationIssue
101 N506b1d47138849218dd5792243fa279e schema:name pubmed_id
102 schema:value 8386942
103 rdf:type schema:PropertyValue
104 N59497f9eca994ec8a0a44823a3928ee7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Humans
106 rdf:type schema:DefinedTerm
107 N5a7db261b6e145f09bcd098690fbcfea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Antioxidants
109 rdf:type schema:DefinedTerm
110 N5fb28b95a446490382be667fe6b278b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Oxidation-Reduction
112 rdf:type schema:DefinedTerm
113 N6bacb5f309434d2ca3416bb5cc64fc18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Aging
115 rdf:type schema:DefinedTerm
116 N721c5fee06b7450ba751974d6c4524c4 schema:name dimensions_id
117 schema:value pub.1044785744
118 rdf:type schema:PropertyValue
119 N99e94ce1ddd1451b844fe6bf98c9605a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Superoxides
121 rdf:type schema:DefinedTerm
122 Na1b38375641b473984ed17481557d974 rdf:first sg:person.010622315454.28
123 rdf:rest rdf:nil
124 Nccef79c18d5f4011aad8fcee66807c52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Free Radicals
126 rdf:type schema:DefinedTerm
127 Nd7bd4199a56241978d3ad202bee07f73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Animals
129 rdf:type schema:DefinedTerm
130 Nea52e52790a24175b117572daedc6e75 schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 Nf5273988bf8941599dc91be28980bedd schema:name doi
133 schema:value 10.1007/bf03324120
134 rdf:type schema:PropertyValue
135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
136 schema:name Medical and Health Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
139 schema:name Clinical Sciences
140 rdf:type schema:DefinedTerm
141 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
142 schema:name Public Health and Health Services
143 rdf:type schema:DefinedTerm
144 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
145 schema:name Psychology and Cognitive Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:1702 schema:inDefinedTermSet anzsrc-for:
148 schema:name Cognitive Sciences
149 rdf:type schema:DefinedTerm
150 sg:grant.2445373 http://pending.schema.org/fundedItem sg:pub.10.1007/bf03324120
151 rdf:type schema:MonetaryGrant
152 sg:grant.2445518 http://pending.schema.org/fundedItem sg:pub.10.1007/bf03324120
153 rdf:type schema:MonetaryGrant
154 sg:journal.1030201 schema:issn 1594-0667
155 1720-8319
156 schema:name Aging Clinical and Experimental Research
157 schema:publisher Springer Nature
158 rdf:type schema:Periodical
159 sg:person.010622315454.28 schema:affiliation grid-institutes:grid.263864.d
160 schema:familyName Sohal
161 schema:givenName R. S.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010622315454.28
163 rdf:type schema:Person
164 sg:pub.10.1007/978-1-4612-5890-2_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021344939
165 https://doi.org/10.1007/978-1-4612-5890-2_12
166 rdf:type schema:CreativeWork
167 sg:pub.10.1007/978-3-642-70853-4_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037613487
168 https://doi.org/10.1007/978-3-642-70853-4_3
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/196454a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013779012
171 https://doi.org/10.1038/196454a0
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/199400a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014985961
174 https://doi.org/10.1038/199400a0
175 rdf:type schema:CreativeWork
176 grid-institutes:grid.263864.d schema:alternateName Department of Biological Sciences, Southern Methodist University, 75275-0376, Dallas, Texas, USA
177 schema:name Department of Biological Sciences, Southern Methodist University, 75275-0376, Dallas, Texas, USA
178 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...