Immune dysfunction in the elderly: Effect of thymic hormone administration on several in vivo and in vitro immune function parameters View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-12

AUTHORS

Umberto Fagiolo, A. Amadori, F. Borghesan, R. Zamarchi, M. L. Veronese, G. De Silvestro, E. Passarella, G. Crepaldi

ABSTRACT

The effects of short- term thymic hormone administration on age- associated immune function were evaluated. Two groups of individuals > 65 years of age were treated for 30 days with thymic extracts (TP1) or placebo; before and after this treatment a panel of in vitro and in vivo parameters was determined according to a very rigorous experimental protocol. In most individuals, TP1 treatment was associated with an improvement in cutaneous delayed- type response to PPD. Moreover, an increase in a circulating T cell subpopulation bearing the CD45R surface antigen (“virgin” T cells), and in NK cell cytotoxic activity was also observed in some subjects. Finally, lymphocyte responsiveness to PHA tended to increase, while no effect on lymphocyte ability to produce IL- 2 following mitogen stimulation was observed. These findings suggest that TP1 treatment may influence age- related alterations in immune function parameters in some subjects. (Again 2: 347–355, 1990) More... »

PAGES

347-355

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03323947

DOI

http://dx.doi.org/10.1007/bf03323947

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022354191

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2094375


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