Evaluation of Temperature Gradient Capillary Electrophoresis for Detection of the Factor V Leiden Mutation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-03

AUTHORS

Kathleen M. Murphy, Michael J. Hafez, Juliet Philips, Kellie Yarnell, Kevin R. Gutshall, Karin D. Berg

ABSTRACT

AIM: The Factor V Leiden mutation (G1691A) is a clinically important polymorphism that results in an increased risk of thrombosis. The goal of this study was to compare a temperature gradient capillary electrophoresis (TGCE) platform for the detection of Factor V gene mutations to a conventional restriction fragment length polymorphism (RFLP) assay. METHODS: Three hundred and four samples were analyzed by both TGCE and a common clinical Mnl I/RFLP assay. Concordance of results between the two assays was observed for 302/304 (99.3%) of the samples. RESULTS: All of the Leiden mutants (23/23, 100%) were identified by TGCE. Of the two discrepant results, one was caused by low peak heights in the TGCE output data and was easily rectified by the addition of a minimum peak height threshold. The second discrepancy resulted from the presence of a G-->A transition 95 bp downstream of the Leiden mutation site. This polymorphism represents a previously unreported alteration of the Factor V gene. CONCLUSIONS: The TGCE assay is less labor-intensive and has a higher throughput capacity than the Mnl I/RFLP assay. TGCE is a less specific assay than the Mnl I/RFLP assay that allows for the detection of novel polymorphisms, but also creates the need for all positive TGCE results to be confirmed by an alternate method such as sequencing. Our results demonstrate that TGCE is a highly sensitive method for mutation detection and has utility for mutation discovery analysis. More... »

PAGES

35-40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03260018

DOI

http://dx.doi.org/10.1007/bf03260018

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024235108

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14529318


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis, Capillary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Factor V", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Restriction Fragment Length", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Department of Pathology, Johns Hopkins School of Medicine, Carnegie 367, 600 North Wolfe St, 21287, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murphy", 
        "givenName": "Kathleen M.", 
        "id": "sg:person.01036007147.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036007147.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Department of Pathology, Johns Hopkins School of Medicine, Carnegie 367, 600 North Wolfe St, 21287, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hafez", 
        "givenName": "Michael J.", 
        "id": "sg:person.0646157056.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646157056.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "SpectruMedix LLC, State College, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Philips", 
        "givenName": "Juliet", 
        "id": "sg:person.01140706436.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140706436.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "SpectruMedix LLC, State College, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yarnell", 
        "givenName": "Kellie", 
        "id": "sg:person.0734734000.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734734000.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "SpectruMedix LLC, State College, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gutshall", 
        "givenName": "Kevin R.", 
        "id": "sg:person.01214255604.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214255604.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins School of Medicine, Carnegie 367, 600 North Wolfe St, 21287, Baltimore, Maryland, USA", 
            "Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berg", 
        "givenName": "Karin D.", 
        "id": "sg:person.01367223175.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367223175.92"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/jcp.52.10.766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002063504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1525-1578(10)60702-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004065561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/modi.2001.24165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004595084", 
          "https://doi.org/10.1054/modi.2001.24165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000456329603300315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005121218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000456329603300315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005121218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1084-8592(99)80037-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006945499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1997.03540400055031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007568088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.1996.d01-1937.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011821607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199504063321403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022445842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1522-2683(200205)23:10<1499::aid-elps1499>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022982345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/369064a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024264501", 
          "https://doi.org/10.1038/369064a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0037-1614378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074543807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074667520", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074679779", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082552346", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0038-1649840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082863777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0038-1655917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083045321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083270579", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/98254dt08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083338413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083340501", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-03", 
    "datePublishedReg": "2003-03-01", 
    "description": "AIM: The Factor V Leiden mutation (G1691A) is a clinically important polymorphism that results in an increased risk of thrombosis. The goal of this study was to compare a temperature gradient capillary electrophoresis (TGCE) platform for the detection of Factor V gene mutations to a conventional restriction fragment length polymorphism (RFLP) assay.\nMETHODS: Three hundred and four samples were analyzed by both TGCE and a common clinical Mnl I/RFLP assay. Concordance of results between the two assays was observed for 302/304 (99.3%) of the samples.\nRESULTS: All of the Leiden mutants (23/23, 100%) were identified by TGCE. Of the two discrepant results, one was caused by low peak heights in the TGCE output data and was easily rectified by the addition of a minimum peak height threshold. The second discrepancy resulted from the presence of a G-->A transition 95 bp downstream of the Leiden mutation site. This polymorphism represents a previously unreported alteration of the Factor V gene.\nCONCLUSIONS: The TGCE assay is less labor-intensive and has a higher throughput capacity than the Mnl I/RFLP assay. TGCE is a less specific assay than the Mnl I/RFLP assay that allows for the detection of novel polymorphisms, but also creates the need for all positive TGCE results to be confirmed by an alternate method such as sequencing. Our results demonstrate that TGCE is a highly sensitive method for mutation detection and has utility for mutation discovery analysis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf03260018", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1116117", 
        "issn": [
          "1084-8592", 
          "1532-8619"
        ], 
        "name": "Molecular Diagnosis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Evaluation of Temperature Gradient Capillary Electrophoresis for Detection of the Factor V Leiden Mutation", 
    "pagination": "35-40", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "73758d23b7e8bb56e3840c78f6ac44108093e472d9cbf43667a1e56c980d1e2d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14529318"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9614965"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf03260018"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024235108"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf03260018", 
      "https://app.dimensions.ai/details/publication/pub.1024235108"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000481.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF03260018"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf03260018'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf03260018'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf03260018'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf03260018'


 

This table displays all metadata directly associated to this object as RDF triples.

196 TRIPLES      21 PREDICATES      55 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf03260018 schema:about N2ca9cf60064c4d8c8656a327a2b48dc1
2 N36a1f9c717774c1d8cc45a5aa59826a7
3 N5371c13e5f444e659d3524475fe79b01
4 N6e19923277f74013869d8ab7f95ff9e3
5 N71cfe8867f264e09805cdf114f134b49
6 N96faca9e1f8b4e16aa801f70f379dc9c
7 Nd7a2a21af7ea420897cfbbc1be331a48
8 anzsrc-for:10
9 anzsrc-for:1004
10 schema:author N94f46b735c31413590110cac8547d423
11 schema:citation sg:pub.10.1038/369064a0
12 sg:pub.10.1054/modi.2001.24165
13 https://app.dimensions.ai/details/publication/pub.1074667520
14 https://app.dimensions.ai/details/publication/pub.1074679779
15 https://app.dimensions.ai/details/publication/pub.1082552346
16 https://app.dimensions.ai/details/publication/pub.1083270579
17 https://app.dimensions.ai/details/publication/pub.1083340501
18 https://doi.org/10.1001/jama.1997.03540400055031
19 https://doi.org/10.1002/1522-2683(200205)23:10<1499::aid-elps1499>3.0.co;2-x
20 https://doi.org/10.1016/s1084-8592(99)80037-x
21 https://doi.org/10.1016/s1525-1578(10)60702-7
22 https://doi.org/10.1046/j.1365-2141.1996.d01-1937.x
23 https://doi.org/10.1055/s-0037-1614378
24 https://doi.org/10.1055/s-0038-1649840
25 https://doi.org/10.1055/s-0038-1655917
26 https://doi.org/10.1056/nejm199504063321403
27 https://doi.org/10.1136/jcp.52.10.766
28 https://doi.org/10.1177/000456329603300315
29 https://doi.org/10.2144/98254dt08
30 schema:datePublished 2003-03
31 schema:datePublishedReg 2003-03-01
32 schema:description AIM: The Factor V Leiden mutation (G1691A) is a clinically important polymorphism that results in an increased risk of thrombosis. The goal of this study was to compare a temperature gradient capillary electrophoresis (TGCE) platform for the detection of Factor V gene mutations to a conventional restriction fragment length polymorphism (RFLP) assay. METHODS: Three hundred and four samples were analyzed by both TGCE and a common clinical Mnl I/RFLP assay. Concordance of results between the two assays was observed for 302/304 (99.3%) of the samples. RESULTS: All of the Leiden mutants (23/23, 100%) were identified by TGCE. Of the two discrepant results, one was caused by low peak heights in the TGCE output data and was easily rectified by the addition of a minimum peak height threshold. The second discrepancy resulted from the presence of a G-->A transition 95 bp downstream of the Leiden mutation site. This polymorphism represents a previously unreported alteration of the Factor V gene. CONCLUSIONS: The TGCE assay is less labor-intensive and has a higher throughput capacity than the Mnl I/RFLP assay. TGCE is a less specific assay than the Mnl I/RFLP assay that allows for the detection of novel polymorphisms, but also creates the need for all positive TGCE results to be confirmed by an alternate method such as sequencing. Our results demonstrate that TGCE is a highly sensitive method for mutation detection and has utility for mutation discovery analysis.
33 schema:genre research_article
34 schema:inLanguage en
35 schema:isAccessibleForFree false
36 schema:isPartOf Nb987debe3f1649738af88e4b3c66599f
37 Nc6042a2cf58d44a583c682cb469419ce
38 sg:journal.1116117
39 schema:name Evaluation of Temperature Gradient Capillary Electrophoresis for Detection of the Factor V Leiden Mutation
40 schema:pagination 35-40
41 schema:productId N3a45d62f28734518b2fdf6ce07655156
42 N449765a03dc74612984b86d5fad3ed40
43 N7ec1a7d526454558b01ebe3aae56f939
44 Na38fd7dc257f4e57a6bdcdb9262aad83
45 Nd7db64d5e6dc47af91b7b6e8f11bebc6
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024235108
47 https://doi.org/10.1007/bf03260018
48 schema:sdDatePublished 2019-04-10T17:24
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher N760d5f44c1c44659809fc98d5682e4a2
51 schema:url http://link.springer.com/10.1007/BF03260018
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N2ca9cf60064c4d8c8656a327a2b48dc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name DNA Mutational Analysis
57 rdf:type schema:DefinedTerm
58 N36a1f9c717774c1d8cc45a5aa59826a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Mutation
60 rdf:type schema:DefinedTerm
61 N3a45d62f28734518b2fdf6ce07655156 schema:name doi
62 schema:value 10.1007/bf03260018
63 rdf:type schema:PropertyValue
64 N43d5bcd7bf2a4be3b30a33cf5d4d9414 schema:name SpectruMedix LLC, State College, Pennsylvania, USA
65 rdf:type schema:Organization
66 N449765a03dc74612984b86d5fad3ed40 schema:name pubmed_id
67 schema:value 14529318
68 rdf:type schema:PropertyValue
69 N5371c13e5f444e659d3524475fe79b01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Polymorphism, Restriction Fragment Length
71 rdf:type schema:DefinedTerm
72 N61b5b9bf45a1456e8f8ec45a92f8d376 schema:name SpectruMedix LLC, State College, Pennsylvania, USA
73 rdf:type schema:Organization
74 N6378a7aff63243cbb7df47fac1a7a88f rdf:first sg:person.01367223175.92
75 rdf:rest rdf:nil
76 N6e19923277f74013869d8ab7f95ff9e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Factor V
78 rdf:type schema:DefinedTerm
79 N7045f25db6c341d39e83822b619da7c0 rdf:first sg:person.0734734000.50
80 rdf:rest Neec37a9241c7458db916888b500d683f
81 N71cfe8867f264e09805cdf114f134b49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Electrophoresis, Capillary
83 rdf:type schema:DefinedTerm
84 N760d5f44c1c44659809fc98d5682e4a2 schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N7ec1a7d526454558b01ebe3aae56f939 schema:name readcube_id
87 schema:value 73758d23b7e8bb56e3840c78f6ac44108093e472d9cbf43667a1e56c980d1e2d
88 rdf:type schema:PropertyValue
89 N80280c1fdea64a35b08b7538828dedbc rdf:first sg:person.01140706436.71
90 rdf:rest N7045f25db6c341d39e83822b619da7c0
91 N94f46b735c31413590110cac8547d423 rdf:first sg:person.01036007147.01
92 rdf:rest Nfb9502bdc82b4481b189716d87794da2
93 N96faca9e1f8b4e16aa801f70f379dc9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Polymerase Chain Reaction
95 rdf:type schema:DefinedTerm
96 Na38fd7dc257f4e57a6bdcdb9262aad83 schema:name nlm_unique_id
97 schema:value 9614965
98 rdf:type schema:PropertyValue
99 Nb987debe3f1649738af88e4b3c66599f schema:volumeNumber 7
100 rdf:type schema:PublicationVolume
101 Nc6042a2cf58d44a583c682cb469419ce schema:issueNumber 1
102 rdf:type schema:PublicationIssue
103 Nd69d8f1aabeb41e7b5eb35ae338c7f27 schema:name SpectruMedix LLC, State College, Pennsylvania, USA
104 rdf:type schema:Organization
105 Nd7a2a21af7ea420897cfbbc1be331a48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Humans
107 rdf:type schema:DefinedTerm
108 Nd7db64d5e6dc47af91b7b6e8f11bebc6 schema:name dimensions_id
109 schema:value pub.1024235108
110 rdf:type schema:PropertyValue
111 Neec37a9241c7458db916888b500d683f rdf:first sg:person.01214255604.52
112 rdf:rest N6378a7aff63243cbb7df47fac1a7a88f
113 Nfb9502bdc82b4481b189716d87794da2 rdf:first sg:person.0646157056.96
114 rdf:rest N80280c1fdea64a35b08b7538828dedbc
115 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
116 schema:name Technology
117 rdf:type schema:DefinedTerm
118 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
119 schema:name Medical Biotechnology
120 rdf:type schema:DefinedTerm
121 sg:journal.1116117 schema:issn 1084-8592
122 1532-8619
123 schema:name Molecular Diagnosis
124 rdf:type schema:Periodical
125 sg:person.01036007147.01 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
126 schema:familyName Murphy
127 schema:givenName Kathleen M.
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036007147.01
129 rdf:type schema:Person
130 sg:person.01140706436.71 schema:affiliation N61b5b9bf45a1456e8f8ec45a92f8d376
131 schema:familyName Philips
132 schema:givenName Juliet
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140706436.71
134 rdf:type schema:Person
135 sg:person.01214255604.52 schema:affiliation N43d5bcd7bf2a4be3b30a33cf5d4d9414
136 schema:familyName Gutshall
137 schema:givenName Kevin R.
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214255604.52
139 rdf:type schema:Person
140 sg:person.01367223175.92 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
141 schema:familyName Berg
142 schema:givenName Karin D.
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367223175.92
144 rdf:type schema:Person
145 sg:person.0646157056.96 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
146 schema:familyName Hafez
147 schema:givenName Michael J.
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646157056.96
149 rdf:type schema:Person
150 sg:person.0734734000.50 schema:affiliation Nd69d8f1aabeb41e7b5eb35ae338c7f27
151 schema:familyName Yarnell
152 schema:givenName Kellie
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734734000.50
154 rdf:type schema:Person
155 sg:pub.10.1038/369064a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024264501
156 https://doi.org/10.1038/369064a0
157 rdf:type schema:CreativeWork
158 sg:pub.10.1054/modi.2001.24165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004595084
159 https://doi.org/10.1054/modi.2001.24165
160 rdf:type schema:CreativeWork
161 https://app.dimensions.ai/details/publication/pub.1074667520 schema:CreativeWork
162 https://app.dimensions.ai/details/publication/pub.1074679779 schema:CreativeWork
163 https://app.dimensions.ai/details/publication/pub.1082552346 schema:CreativeWork
164 https://app.dimensions.ai/details/publication/pub.1083270579 schema:CreativeWork
165 https://app.dimensions.ai/details/publication/pub.1083340501 schema:CreativeWork
166 https://doi.org/10.1001/jama.1997.03540400055031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007568088
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1002/1522-2683(200205)23:10<1499::aid-elps1499>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022982345
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/s1084-8592(99)80037-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006945499
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/s1525-1578(10)60702-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004065561
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1046/j.1365-2141.1996.d01-1937.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011821607
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1055/s-0037-1614378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074543807
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1055/s-0038-1649840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082863777
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1055/s-0038-1655917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083045321
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1056/nejm199504063321403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022445842
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1136/jcp.52.10.766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002063504
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1177/000456329603300315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005121218
187 rdf:type schema:CreativeWork
188 https://doi.org/10.2144/98254dt08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083338413
189 rdf:type schema:CreativeWork
190 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
191 schema:name Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
192 Department of Pathology, Johns Hopkins School of Medicine, Carnegie 367, 600 North Wolfe St, 21287, Baltimore, Maryland, USA
193 rdf:type schema:Organization
194 https://www.grid.ac/institutes/grid.21925.3d schema:alternateName University of Pittsburgh
195 schema:name Department of Pathology, Johns Hopkins School of Medicine, Carnegie 367, 600 North Wolfe St, 21287, Baltimore, Maryland, USA
196 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...