Prognostic significance of synchronous and metachronous bilateral breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-09

AUTHORS

James Kollias, Ian O. Ellis, Christopher W. Elston, Roger W. Blamey

ABSTRACT

Women previously treated for primary operable breast cancer are at increased risk of developing cancer in the contralateral breast, but the clinical significance of this development is unclear. The purpose of this study was to assess the impact of synchronous bilateral breast cancer or the development of a metachronous contralateral breast primary on the prognosis. In a series of 3210 women age < or = 70 years treated between 1975 and 1995 for primary operable breast cancer, 106 were identified to have bilateral breast cancer. Of these women, 26 were noted to have synchronous bilateral breast primaries (0.8%), and 80 developed a contralateral breast cancer after treatment for an initial primary breast cancer. Using life-tables analysis, there was a significant difference in survival between women with unilateral breast cancer, those with synchronous bilateral breast cancers, and those with metachronous contralateral breast with survivals at 16 years of 53.8%, 42.4%, and 60.1%, respectively (p < 0.0001), from the date of the diagnosis of the first primary tumor. There was no difference in survival seen between the three groups when survival was calculated from the date of diagnosis of the second primary in cases of metachronous contralateral breast cancer (p = 0.31). When contralateral breast cancer was incorporated as a time-dependent covariate in a Cox multivariate model together with the three factors used to determine the Nottingham Prognostic Index (invasive tumor size, grade, and lymph node stage), contralateral breast cancer continued to be a significant prognostic determinant (p = 0.02). The survival of women with synchronous bilateral breast cancer or metachronous breast cancers diagnosed within 2 years of the original primary was worse than those with unilateral disease. However, the time duration to metachronous contralateral breast cancer did not have prognostic significance in a multivariate model compared with the prognostic features of the original primary. More... »

PAGES

1117-1124

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03215857

DOI

http://dx.doi.org/10.1007/bf03215857

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033896298

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11571945


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Intraductal, Noninfiltrating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multivariate Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Multiple Primary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Second Primary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nottingham City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412920.c", 
          "name": [
            "Professorial Unit of Surgery, City Hospital, Hucknall Road, NG5 1PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kollias", 
        "givenName": "James", 
        "id": "sg:person.01371105147.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371105147.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412920.c", 
          "name": [
            "Department of Histopathology, City Hospital, Hucknall Road, NG5 1PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellis", 
        "givenName": "Ian O.", 
        "id": "sg:person.01054612302.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412920.c", 
          "name": [
            "Department of Histopathology, City Hospital, Hucknall Road, NG5 1PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elston", 
        "givenName": "Christopher W.", 
        "id": "sg:person.010676703014.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010676703014.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412920.c", 
          "name": [
            "Professorial Unit of Surgery, City Hospital, Hucknall Road, NG5 1PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blamey", 
        "givenName": "Roger W.", 
        "id": "sg:person.015650304144.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015650304144.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00000658-198506000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001245024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198506000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001245024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19880715)62:2<412::aid-cncr2820620228>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001796201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1982.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001864868", 
          "https://doi.org/10.1038/bjc.1982.62"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1982.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001864868", 
          "https://doi.org/10.1038/bjc.1982.62"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800670720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002915381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1992.tb01032.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003509058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19850201)55:3<643::aid-cncr2820550328>3.0.co;2-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004319770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010222506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010222506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1986.201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013915488", 
          "https://doi.org/10.1038/bjc.1986.201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1986.201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013915488", 
          "https://doi.org/10.1038/bjc.1986.201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014383278", 
          "https://doi.org/10.1007/bf00666005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014383278", 
          "https://doi.org/10.1007/bf00666005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800770216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018329109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19841215)54:12<3002::aid-cncr2820541231>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020296243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800710924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028104235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197608)38:2<931::aid-cncr2820380242>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030177243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01840834", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032983382", 
          "https://doi.org/10.1007/bf01840834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/ejso.1999.0711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036610467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19970401)79:7<1362::aid-cncr14>3.0.co;2-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038307523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9776(96)90064-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042473427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19850315)55:6<1414::aid-cncr2820550641>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044851522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1984.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045232295", 
          "https://doi.org/10.1038/bjc.1984.12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1984.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045232295", 
          "https://doi.org/10.1038/bjc.1984.12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0960-9776(93)90057-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045275533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19820915)50:6<1191::aid-cncr2820500628>3.0.co;2-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046137930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1987.230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047698959", 
          "https://doi.org/10.1038/bjc.1987.230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1987.230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047698959", 
          "https://doi.org/10.1038/bjc.1987.230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(94)90516-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049782463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19931215)72:12<3629::aid-cncr2820721213>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051509727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1988.191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056443213", 
          "https://doi.org/10.1038/bjc.1988.191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1988.191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056443213", 
          "https://doi.org/10.1038/bjc.1988.191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.aje.a116565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076582432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.aje.a116566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076582444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081436209", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082209179", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082674069", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082685987", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082752761", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1993.11.8.1545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082762683"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-09", 
    "datePublishedReg": "2001-09-01", 
    "description": "Women previously treated for primary operable breast cancer are at increased risk of developing cancer in the contralateral breast, but the clinical significance of this development is unclear. The purpose of this study was to assess the impact of synchronous bilateral breast cancer or the development of a metachronous contralateral breast primary on the prognosis. In a series of 3210 women age < or = 70 years treated between 1975 and 1995 for primary operable breast cancer, 106 were identified to have bilateral breast cancer. Of these women, 26 were noted to have synchronous bilateral breast primaries (0.8%), and 80 developed a contralateral breast cancer after treatment for an initial primary breast cancer. Using life-tables analysis, there was a significant difference in survival between women with unilateral breast cancer, those with synchronous bilateral breast cancers, and those with metachronous contralateral breast with survivals at 16 years of 53.8%, 42.4%, and 60.1%, respectively (p < 0.0001), from the date of the diagnosis of the first primary tumor. There was no difference in survival seen between the three groups when survival was calculated from the date of diagnosis of the second primary in cases of metachronous contralateral breast cancer (p = 0.31). When contralateral breast cancer was incorporated as a time-dependent covariate in a Cox multivariate model together with the three factors used to determine the Nottingham Prognostic Index (invasive tumor size, grade, and lymph node stage), contralateral breast cancer continued to be a significant prognostic determinant (p = 0.02). The survival of women with synchronous bilateral breast cancer or metachronous breast cancers diagnosed within 2 years of the original primary was worse than those with unilateral disease. However, the time duration to metachronous contralateral breast cancer did not have prognostic significance in a multivariate model compared with the prognostic features of the original primary.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf03215857", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1086446", 
        "issn": [
          "0364-2313", 
          "1432-2323"
        ], 
        "name": "World Journal of Surgery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "name": "Prognostic significance of synchronous and metachronous bilateral breast cancer", 
    "pagination": "1117-1124", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a17925ae4e6908078bc67cec71e2b987483eeb38974e4d62c391c6acb4719fab"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11571945"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7704052"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf03215857"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033896298"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf03215857", 
      "https://app.dimensions.ai/details/publication/pub.1033896298"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2FBF03215857"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf03215857'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf03215857'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf03215857'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf03215857'


 

This table displays all metadata directly associated to this object as RDF triples.

260 TRIPLES      21 PREDICATES      79 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf03215857 schema:about N027ab31cfbf44557bd713f44e2ef9c20
2 N16ca419b05de46b59560a3237ec6d717
3 N21908bb3dfa24e6caa6af4c71d46bb6d
4 N34c4e21b0e4445fca2b71ddc298ac080
5 N3bef3a8939274b7fa256d87da87bd80b
6 N411e4a7ad00144198eb1d1b3798df14d
7 N4137ddc6614f4b8cabc6090358624b9a
8 N6331721c7e4e4d51976c4a591a8261f4
9 N6643242e77b143f2ac7bf01ded92d7d3
10 N9b315a37765e41d4b3842bc941a4d83d
11 Nb1fb9c5575064bf8914bd2b0b7c9edd1
12 Nb28c3b35156f47959db34a7dc08feda5
13 Nd4c04a51b11049dcb5b541f58eb033a6
14 Nd71262c02e91443e817de41df94dffe7
15 Ndde42dd618104a18b7f2c111d1389fea
16 Ne199b75adce54775ba35e444d687629f
17 Nf35933e57523418fb197ad6f5b64e3bc
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author N7ad1ff526c09426ebbf20da38dbef65f
21 schema:citation sg:pub.10.1007/bf00666005
22 sg:pub.10.1007/bf01840834
23 sg:pub.10.1038/bjc.1982.62
24 sg:pub.10.1038/bjc.1984.12
25 sg:pub.10.1038/bjc.1986.201
26 sg:pub.10.1038/bjc.1987.230
27 sg:pub.10.1038/bjc.1988.191
28 https://app.dimensions.ai/details/publication/pub.1081436209
29 https://app.dimensions.ai/details/publication/pub.1082209179
30 https://app.dimensions.ai/details/publication/pub.1082674069
31 https://app.dimensions.ai/details/publication/pub.1082685987
32 https://app.dimensions.ai/details/publication/pub.1082752761
33 https://doi.org/10.1002/(sici)1097-0142(19970401)79:7<1362::aid-cncr14>3.0.co;2-y
34 https://doi.org/10.1002/1097-0142(197608)38:2<931::aid-cncr2820380242>3.0.co;2-o
35 https://doi.org/10.1002/1097-0142(19820915)50:6<1191::aid-cncr2820500628>3.0.co;2-f
36 https://doi.org/10.1002/1097-0142(19841215)54:12<3002::aid-cncr2820541231>3.0.co;2-v
37 https://doi.org/10.1002/1097-0142(19850201)55:3<643::aid-cncr2820550328>3.0.co;2-l
38 https://doi.org/10.1002/1097-0142(19850315)55:6<1414::aid-cncr2820550641>3.0.co;2-d
39 https://doi.org/10.1002/1097-0142(19880715)62:2<412::aid-cncr2820620228>3.0.co;2-3
40 https://doi.org/10.1002/1097-0142(19931215)72:12<3629::aid-cncr2820721213>3.0.co;2-t
41 https://doi.org/10.1002/bjs.1800670720
42 https://doi.org/10.1002/bjs.1800710924
43 https://doi.org/10.1002/bjs.1800770216
44 https://doi.org/10.1016/0360-3016(94)90516-9
45 https://doi.org/10.1016/0960-9776(93)90057-m
46 https://doi.org/10.1016/s0960-9776(96)90064-8
47 https://doi.org/10.1053/ejso.1999.0711
48 https://doi.org/10.1093/oxfordjournals.aje.a116565
49 https://doi.org/10.1093/oxfordjournals.aje.a116566
50 https://doi.org/10.1097/00000658-198506000-00001
51 https://doi.org/10.1111/j.1365-2559.1991.tb00229.x
52 https://doi.org/10.1111/j.1365-2559.1992.tb01032.x
53 https://doi.org/10.1200/jco.1993.11.8.1545
54 schema:datePublished 2001-09
55 schema:datePublishedReg 2001-09-01
56 schema:description Women previously treated for primary operable breast cancer are at increased risk of developing cancer in the contralateral breast, but the clinical significance of this development is unclear. The purpose of this study was to assess the impact of synchronous bilateral breast cancer or the development of a metachronous contralateral breast primary on the prognosis. In a series of 3210 women age < or = 70 years treated between 1975 and 1995 for primary operable breast cancer, 106 were identified to have bilateral breast cancer. Of these women, 26 were noted to have synchronous bilateral breast primaries (0.8%), and 80 developed a contralateral breast cancer after treatment for an initial primary breast cancer. Using life-tables analysis, there was a significant difference in survival between women with unilateral breast cancer, those with synchronous bilateral breast cancers, and those with metachronous contralateral breast with survivals at 16 years of 53.8%, 42.4%, and 60.1%, respectively (p < 0.0001), from the date of the diagnosis of the first primary tumor. There was no difference in survival seen between the three groups when survival was calculated from the date of diagnosis of the second primary in cases of metachronous contralateral breast cancer (p = 0.31). When contralateral breast cancer was incorporated as a time-dependent covariate in a Cox multivariate model together with the three factors used to determine the Nottingham Prognostic Index (invasive tumor size, grade, and lymph node stage), contralateral breast cancer continued to be a significant prognostic determinant (p = 0.02). The survival of women with synchronous bilateral breast cancer or metachronous breast cancers diagnosed within 2 years of the original primary was worse than those with unilateral disease. However, the time duration to metachronous contralateral breast cancer did not have prognostic significance in a multivariate model compared with the prognostic features of the original primary.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N1f1c1abd89954cfd8ace46a4fb2b84ac
61 N3e9cd3fcd4174f3fa49488b0abc2ff35
62 sg:journal.1086446
63 schema:name Prognostic significance of synchronous and metachronous bilateral breast cancer
64 schema:pagination 1117-1124
65 schema:productId N0ab83c43e32a444eaae601470f6845ee
66 N2b906c04038b4af189f9f6db62d9cc40
67 N60d737b603d84f3e8b7192f76adb5e30
68 N9c42af38f3ae481ebe18cfcbe7e9b980
69 Nfdbccac1a4ae43868a2a70dc49e21f62
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033896298
71 https://doi.org/10.1007/bf03215857
72 schema:sdDatePublished 2019-04-11T00:16
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nff3fe4a091164366a614d8df07aef9af
75 schema:url http://link.springer.com/10.1007%2FBF03215857
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N027ab31cfbf44557bd713f44e2ef9c20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Neoplasms, Multiple Primary
81 rdf:type schema:DefinedTerm
82 N0ab83c43e32a444eaae601470f6845ee schema:name readcube_id
83 schema:value a17925ae4e6908078bc67cec71e2b987483eeb38974e4d62c391c6acb4719fab
84 rdf:type schema:PropertyValue
85 N16ca419b05de46b59560a3237ec6d717 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Survival Analysis
87 rdf:type schema:DefinedTerm
88 N1f1c1abd89954cfd8ace46a4fb2b84ac schema:volumeNumber 25
89 rdf:type schema:PublicationVolume
90 N21908bb3dfa24e6caa6af4c71d46bb6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Time Factors
92 rdf:type schema:DefinedTerm
93 N2b906c04038b4af189f9f6db62d9cc40 schema:name doi
94 schema:value 10.1007/bf03215857
95 rdf:type schema:PropertyValue
96 N2edeeb97ef864fd0b581d0c8f0bafe08 rdf:first sg:person.01054612302.65
97 rdf:rest Na1a430c4c5294c0ba0d5aa45413d99c5
98 N34c4e21b0e4445fca2b71ddc298ac080 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Adult
100 rdf:type schema:DefinedTerm
101 N3bef3a8939274b7fa256d87da87bd80b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Follow-Up Studies
103 rdf:type schema:DefinedTerm
104 N3e9cd3fcd4174f3fa49488b0abc2ff35 schema:issueNumber 9
105 rdf:type schema:PublicationIssue
106 N411e4a7ad00144198eb1d1b3798df14d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Middle Aged
108 rdf:type schema:DefinedTerm
109 N4137ddc6614f4b8cabc6090358624b9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Breast Neoplasms
111 rdf:type schema:DefinedTerm
112 N60d737b603d84f3e8b7192f76adb5e30 schema:name pubmed_id
113 schema:value 11571945
114 rdf:type schema:PropertyValue
115 N62c52394ee9d4e1b84ce4a1d3f1acb6b rdf:first sg:person.015650304144.58
116 rdf:rest rdf:nil
117 N6331721c7e4e4d51976c4a591a8261f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Aged
119 rdf:type schema:DefinedTerm
120 N6643242e77b143f2ac7bf01ded92d7d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Multivariate Analysis
122 rdf:type schema:DefinedTerm
123 N7ad1ff526c09426ebbf20da38dbef65f rdf:first sg:person.01371105147.16
124 rdf:rest N2edeeb97ef864fd0b581d0c8f0bafe08
125 N9b315a37765e41d4b3842bc941a4d83d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N9c42af38f3ae481ebe18cfcbe7e9b980 schema:name dimensions_id
129 schema:value pub.1033896298
130 rdf:type schema:PropertyValue
131 Na1a430c4c5294c0ba0d5aa45413d99c5 rdf:first sg:person.010676703014.40
132 rdf:rest N62c52394ee9d4e1b84ce4a1d3f1acb6b
133 Nb1fb9c5575064bf8914bd2b0b7c9edd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Prognosis
135 rdf:type schema:DefinedTerm
136 Nb28c3b35156f47959db34a7dc08feda5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Female
138 rdf:type schema:DefinedTerm
139 Nd4c04a51b11049dcb5b541f58eb033a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Carcinoma, Intraductal, Noninfiltrating
141 rdf:type schema:DefinedTerm
142 Nd71262c02e91443e817de41df94dffe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Neoplasms, Second Primary
144 rdf:type schema:DefinedTerm
145 Ndde42dd618104a18b7f2c111d1389fea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Neoplasm Staging
147 rdf:type schema:DefinedTerm
148 Ne199b75adce54775ba35e444d687629f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Risk
150 rdf:type schema:DefinedTerm
151 Nf35933e57523418fb197ad6f5b64e3bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Survival Rate
153 rdf:type schema:DefinedTerm
154 Nfdbccac1a4ae43868a2a70dc49e21f62 schema:name nlm_unique_id
155 schema:value 7704052
156 rdf:type schema:PropertyValue
157 Nff3fe4a091164366a614d8df07aef9af schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical and Health Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
163 schema:name Oncology and Carcinogenesis
164 rdf:type schema:DefinedTerm
165 sg:journal.1086446 schema:issn 0364-2313
166 1432-2323
167 schema:name World Journal of Surgery
168 rdf:type schema:Periodical
169 sg:person.01054612302.65 schema:affiliation https://www.grid.ac/institutes/grid.412920.c
170 schema:familyName Ellis
171 schema:givenName Ian O.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65
173 rdf:type schema:Person
174 sg:person.010676703014.40 schema:affiliation https://www.grid.ac/institutes/grid.412920.c
175 schema:familyName Elston
176 schema:givenName Christopher W.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010676703014.40
178 rdf:type schema:Person
179 sg:person.01371105147.16 schema:affiliation https://www.grid.ac/institutes/grid.412920.c
180 schema:familyName Kollias
181 schema:givenName James
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371105147.16
183 rdf:type schema:Person
184 sg:person.015650304144.58 schema:affiliation https://www.grid.ac/institutes/grid.412920.c
185 schema:familyName Blamey
186 schema:givenName Roger W.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015650304144.58
188 rdf:type schema:Person
189 sg:pub.10.1007/bf00666005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014383278
190 https://doi.org/10.1007/bf00666005
191 rdf:type schema:CreativeWork
192 sg:pub.10.1007/bf01840834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032983382
193 https://doi.org/10.1007/bf01840834
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/bjc.1982.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001864868
196 https://doi.org/10.1038/bjc.1982.62
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/bjc.1984.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045232295
199 https://doi.org/10.1038/bjc.1984.12
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/bjc.1986.201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013915488
202 https://doi.org/10.1038/bjc.1986.201
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/bjc.1987.230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047698959
205 https://doi.org/10.1038/bjc.1987.230
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/bjc.1988.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056443213
208 https://doi.org/10.1038/bjc.1988.191
209 rdf:type schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1081436209 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1082209179 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1082674069 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1082685987 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1082752761 schema:CreativeWork
215 https://doi.org/10.1002/(sici)1097-0142(19970401)79:7<1362::aid-cncr14>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1038307523
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/1097-0142(197608)38:2<931::aid-cncr2820380242>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1030177243
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/1097-0142(19820915)50:6<1191::aid-cncr2820500628>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1046137930
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1002/1097-0142(19841215)54:12<3002::aid-cncr2820541231>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1020296243
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1002/1097-0142(19850201)55:3<643::aid-cncr2820550328>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1004319770
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1002/1097-0142(19850315)55:6<1414::aid-cncr2820550641>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1044851522
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1002/1097-0142(19880715)62:2<412::aid-cncr2820620228>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001796201
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1002/1097-0142(19931215)72:12<3629::aid-cncr2820721213>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1051509727
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1002/bjs.1800670720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002915381
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1002/bjs.1800710924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028104235
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/bjs.1800770216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018329109
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/0360-3016(94)90516-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049782463
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/0960-9776(93)90057-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1045275533
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0960-9776(96)90064-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042473427
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1053/ejso.1999.0711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036610467
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/oxfordjournals.aje.a116565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076582432
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1093/oxfordjournals.aje.a116566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076582444
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1097/00000658-198506000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001245024
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1111/j.1365-2559.1991.tb00229.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010222506
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1111/j.1365-2559.1992.tb01032.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003509058
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1200/jco.1993.11.8.1545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082762683
256 rdf:type schema:CreativeWork
257 https://www.grid.ac/institutes/grid.412920.c schema:alternateName Nottingham City Hospital
258 schema:name Department of Histopathology, City Hospital, Hucknall Road, NG5 1PB, Nottingham, UK
259 Professorial Unit of Surgery, City Hospital, Hucknall Road, NG5 1PB, Nottingham, UK
260 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...