Chemical enhancers for transdermal drug transport View Full Text


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Article Info

DATE

2001-03

AUTHORS

K. Bauerová, D. Matušová, Z. Kassai

ABSTRACT

In its first part, this review paper discusses skin morphology and barrier function of the stratum corneum for drug permeation after its transdermal administration or topical application. Further, the paper presents the main methods for overcoming the skin permeation barrier, which plays an important role for transdermal drug administration. Focus is on the method of chemical permeation enhancement. The chemical enhancers are categorised by their chemical structure. Examples of the most effective enhancers are given for the chemical groups of alcohols, amines and amides, polyalcohols, terpenes, fatty acids and their esters, macro cyclic compounds, sulfoxides, tensides, and others, as e.g. soft enhancers. More... »

PAGES

85-94

References to SciGraph publications

  • 1994-02. In Vivo and in Vitro Analysis of Skin Penetration Enhancement Based on a Two-Layer Diffusion Model with Polar and Nonpolar Routes in the Stratum Corneum in PHARMACEUTICAL RESEARCH
  • 1986-09. Regional variation in percutaneous absorption in man: measurement by the stripping method in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1993-07. ε-Aminocaproic Acid Esters as Transdermal Penetration Enhancing Agents in PHARMACEUTICAL RESEARCH
  • 1993-12. Disparity of in Vitro and in Vivo Oleic Acid-Enhanced β-Estradiol Percutaneous Absorption Across Human Skin in PHARMACEUTICAL RESEARCH
  • 1994-03. Comparative Analysis of Percutaneous Absorption Enhancement by d-Limonene and Oleic Acid Based on a Skin Diffusion Model in PHARMACEUTICAL RESEARCH
  • 1990-11. Transdermal Delivery of Bioactive Peptides: The Effect of n-Decylmethyl Sulfoxide, pH, and Inhibitors on Enkephalin Metabolism and Transport in PHARMACEUTICAL RESEARCH
  • 1994-05. Application of in Vivo Microdialysis to Transdermal Absorption of Methotrexate in Rats in PHARMACEUTICAL RESEARCH
  • 1990-08. Percutaneous Penetration Enhancement in Vivo Measured by Attenuated Total Reflectance Infrared Spectroscopy in PHARMACEUTICAL RESEARCH
  • 1994-06. Percutaneous Absorption of 2′,3′-Dideoxyinosine in Rats in PHARMACEUTICAL RESEARCH
  • 1992-12. Percutaneous Absorption Enhancement of Leuprolide in PHARMACEUTICAL RESEARCH
  • 1982. Skin Permeability in NONE
  • 1990-01. Percutaneous Penetration of Acyclovir Through Excised Hairless Mouse and Rat Skin: Effect of Vehicle and Percutaneous Penetration Enhancer in PHARMACEUTICAL RESEARCH
  • 1990-07. Contributions of Drug Solubilization, Partitioning, Barrier Disruption, and Solvent Permeation to the Enhancement of Skin Permeation of Various Compounds with Fatty Acids and Amines in PHARMACEUTICAL RESEARCH
  • 1990-01. Enhancement of the in Vitro Skin Permeability of Azidothymidine (AZT) via Iontophoresis and Chemical Enhancer in PHARMACEUTICAL RESEARCH
  • 1990-05. Disposition and Metabolic Profiling of the Penetration Enhancer Azone. I. In Vivo Studies: Urinary Profiles of Hamster, Rat, Monkey, and Man in PHARMACEUTICAL RESEARCH
  • 1991-01. Terpenes and the Lipid–Protein–Partitioning Theory of Skin Penetration Enhancement in PHARMACEUTICAL RESEARCH
  • 1991-03. Evidence that Oleic Acid Exists in a Separate Phase Within Stratum Corneum Lipids in PHARMACEUTICAL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf03190381

    DOI

    http://dx.doi.org/10.1007/bf03190381

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009966061

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11554439


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