A comparison of the pharmacokinetics of meropenem after intravenous administration by injection over 2, 3 and 5 minutes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-09

AUTHORS

H. K. Jones, H. C. Kelly, M. Hutchison, R. A. Yates, F. Ross, C. Lomax, S. Freestone, D. Webb

ABSTRACT

The pharmacokinetics of meropenem were determined in 9 healthy volunteers after the administration of 1 g dose by injection over 2, 3 or 5 min. Peak plasma concentrations were not significantly different across the three rates of administration and, due to the finite time required for complete mixing of the blood in the central compartment, did not always occur at the end of the injection. Overall exposure to meropenem was unchanged by the more rapid rates of administration. Plasma clearance, terminal half-life and volume of distribution were virtually unchanged. Within 10 min after the start of the injection, the plasma concentrations from all three injections were very similar indicating that dosing over 2, 3 or 5 min would result in similar antimicrobial cover and, therefore, comparable efficacy. Comparison of the data derived from the three injections indicated that rapid administration of meropenem did not appreciably alter its disposition pharmacokinetics. Tolerability of meropenem was unchanged with the more rapid administration rate. More... »

PAGES

193-199

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03189806

DOI

http://dx.doi.org/10.1007/bf03189806

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039215352

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9358198


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