Pharmacokinetics and metabolism of [35S]-Thiazolidine carboxylic acid in the rat. I Elimination and distribution View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-10

AUTHORS

M. F. Harmand, P. Blanquet

ABSTRACT

The localization and elimination of35S-Thiazolidine carboxylic acid has been studied in rats following a single oral dose (100 mg/kg) and multiple oral doses (100 mg/kg/day) over 15 days.The compound was rapidly and completely absorbed as evaluated by the time of the maximum plasma35S-concentration (140 μg eq/ml at 30 min) and the amount of radioactivity in the feces (less than 1% of the dose over 48 h). Urinary excretion seems to be the unique route of elimination.There was specific tissue accumulation of drug or metabolite, particularly in liver (29% of the dose at 3h), pancreas (7% of the dose at 3h), adrenals (320 μg eq/g at 3h), pituitary and thyroid (230 μg eq/g at 3h). Fixation of radioactivity appears significantly higher after chronic treatment than after acute treatment. More... »

PAGES

323-327

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03189636

DOI

http://dx.doi.org/10.1007/bf03189636

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006359430

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7166184


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