Effect of imipramine and amitriptyline on circadian locomotor activity rhythm in the field mouseMus booduga View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-11

AUTHORS

P Subramanian, R Subbaraj

ABSTRACT

We have performed experiments on the influence of imipramine and amitriptyline (antidepressant drugs) offered through drinking water on the period length (τ) of the circadian locomotor activity rhythm in the field mouseMus booduga under continuous darkness (DD). Ingestion of imipramine to mice under freemnning conditions caused lengthening of the activity rhythm whereas amitriptyline caused dissociation of activity components. Furthermore, the amount of activity (α) is significantly reduced (P< 0-005) during imipramine as well as amitriptyline treatment. The action of these antidepressants may be explained by their action on serotonergic terminals in the suprachiasmatic nucleus, the putative circadian pacemaker in mammals. More... »

PAGES

503-507

References to SciGraph publications

  • 1982-11. Antidepressant drugs can slow or dissociate circadian rhythms in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1976-10. A functional analysis of circadian pacemakers in nocturnal rodents in JOURNAL OF COMPARATIVE PHYSIOLOGY A
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf03186413

    DOI

    http://dx.doi.org/10.1007/bf03186413

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036020114


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