Proton therapy for tumors of the skull base View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-06

AUTHORS

John E. Munzenrider, Norbert J. Liebsch

ABSTRACT

Charged particle beams are ideal for treating skull base and cervical spine tumors: dose can be focused in the target, while achieving significant sparing of the brain, brain stem, cervical cord, and optic nerves and chiasm. For skull base tumors, 10-year local control rates with combined proton-photon therapy are highest for chondrosarcomas, intermediate for male chordomas, and lowest for female chordomas (94%, 65%, and 42%, respectively). For cervical spine tumors, 10-year local control rates are not significantly different for chordomas and chondrosarcomas (54% and 48%, respectively), nor is there any difference in local control between males and females. Observed treatment-related morbidity has been judged acceptable, in view of the major morbidity and mortality which accompany uncontrolled tumor growth. More... »

PAGES

57-63

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03038890

DOI

http://dx.doi.org/10.1007/bf03038890

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032828853

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10394399


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chondrosarcoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chordoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proton Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy Planning, Computer-Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy, Computer-Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy, Conformal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skull Base Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spinal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, X-Ray Computed", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Radiation Oncology, Massachusett General Hospital, Harvard University Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Radiation Oncology, Massachusett General Hospital, Harvard University Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Munzenrider", 
        "givenName": "John E.", 
        "id": "sg:person.0637022555.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637022555.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiation Oncology, Massachusett General Hospital, Harvard University Medical School, 02115, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Radiation Oncology, Massachusett General Hospital, Harvard University Medical School, 02115, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liebsch", 
        "givenName": "Norbert J.", 
        "id": "sg:person.01156734301.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156734301.76"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1999-06", 
    "datePublishedReg": "1999-06-01", 
    "description": "Charged particle beams are ideal for treating skull base and cervical spine tumors: dose can be focused in the target, while achieving significant sparing of the brain, brain stem, cervical cord, and optic nerves and chiasm. For skull base tumors, 10-year local control rates with combined proton-photon therapy are highest for chondrosarcomas, intermediate for male chordomas, and lowest for female chordomas (94%, 65%, and 42%, respectively). For cervical spine tumors, 10-year local control rates are not significantly different for chordomas and chondrosarcomas (54% and 48%, respectively), nor is there any difference in local control between males and females. Observed treatment-related morbidity has been judged acceptable, in view of the major morbidity and mortality which accompany uncontrolled tumor growth.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf03038890", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2435408", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1054450", 
        "issn": [
          "0179-7158", 
          "1439-099X"
        ], 
        "name": "Strahlentherapie und Onkologie", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "Suppl 2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "175"
      }
    ], 
    "keywords": [
      "cervical spine tumors", 
      "local control rate", 
      "spine tumors", 
      "control rate", 
      "skull base", 
      "treatment-related morbidity", 
      "skull base tumors", 
      "uncontrolled tumor growth", 
      "major morbidity", 
      "cervical cord", 
      "optic nerve", 
      "brain stem", 
      "significant sparing", 
      "local control", 
      "tumor growth", 
      "tumors", 
      "chordoma", 
      "morbidity", 
      "therapy", 
      "chondrosarcoma", 
      "proton therapy", 
      "nerve", 
      "chiasm", 
      "cord", 
      "mortality", 
      "sparing", 
      "dose", 
      "brain", 
      "males", 
      "females", 
      "rate", 
      "target", 
      "differences", 
      "control", 
      "stem", 
      "base", 
      "growth", 
      "view", 
      "beam", 
      "particle beams"
    ], 
    "name": "Proton therapy for tumors of the skull base", 
    "pagination": "57-63", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032828853"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf03038890"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10394399"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf03038890", 
      "https://app.dimensions.ai/details/publication/pub.1032828853"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_310.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf03038890"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf03038890'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf03038890'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf03038890'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf03038890'


 

This table displays all metadata directly associated to this object as RDF triples.

166 TRIPLES      20 PREDICATES      80 URIs      72 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf03038890 schema:about N454c8ccb4b6649a39968a2fcb50a1587
2 N45dc5df13be748c6b40ecc80187ebd48
3 N5db4b9a24bee43c488de263a1017ba2d
4 N8a4caeaf817a46a5971017f6a39cea56
5 N98fdd027dae841db82450832735580ea
6 Na6184441a5cc462ab22675b22bf9a305
7 Na93504513fbd44d7ae1431328641f8ed
8 Nbae3a63f58244d1997c57930210c0abd
9 Nbeed96e1b3f14457bc1546e14727e66a
10 Nc2b3154a164245a8a5a7f46558edc8dc
11 Nc30cfe6658ce489a81a6153a8f1baafa
12 Nd5bb37af4c6149f59ac3f4d805333efd
13 Ndbfce3fc32b14dc9a0f997c9ffd54f85
14 Nffdbe49172994ac283a8585766b0f4d1
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N8394eb915d354697aa0f7e0ebb7c7cf5
18 schema:datePublished 1999-06
19 schema:datePublishedReg 1999-06-01
20 schema:description Charged particle beams are ideal for treating skull base and cervical spine tumors: dose can be focused in the target, while achieving significant sparing of the brain, brain stem, cervical cord, and optic nerves and chiasm. For skull base tumors, 10-year local control rates with combined proton-photon therapy are highest for chondrosarcomas, intermediate for male chordomas, and lowest for female chordomas (94%, 65%, and 42%, respectively). For cervical spine tumors, 10-year local control rates are not significantly different for chordomas and chondrosarcomas (54% and 48%, respectively), nor is there any difference in local control between males and females. Observed treatment-related morbidity has been judged acceptable, in view of the major morbidity and mortality which accompany uncontrolled tumor growth.
21 schema:genre article
22 schema:isAccessibleForFree false
23 schema:isPartOf Nb648bc573f5044568c982b6005327579
24 Nd30537f93b404a88bae2e6d0ba2caf81
25 sg:journal.1054450
26 schema:keywords base
27 beam
28 brain
29 brain stem
30 cervical cord
31 cervical spine tumors
32 chiasm
33 chondrosarcoma
34 chordoma
35 control
36 control rate
37 cord
38 differences
39 dose
40 females
41 growth
42 local control
43 local control rate
44 major morbidity
45 males
46 morbidity
47 mortality
48 nerve
49 optic nerve
50 particle beams
51 proton therapy
52 rate
53 significant sparing
54 skull base
55 skull base tumors
56 sparing
57 spine tumors
58 stem
59 target
60 therapy
61 treatment-related morbidity
62 tumor growth
63 tumors
64 uncontrolled tumor growth
65 view
66 schema:name Proton therapy for tumors of the skull base
67 schema:pagination 57-63
68 schema:productId N09742f28e6aa4ce2ad096bb1589e1c88
69 Na681e02b7c7d46ddb633f83e79c36ebe
70 Nb6ad4237f89348ada676c9c7d9aa8a38
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032828853
72 https://doi.org/10.1007/bf03038890
73 schema:sdDatePublished 2022-08-04T16:53
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Nb46b9ca2f92847b2ab3db32874976440
76 schema:url https://doi.org/10.1007/bf03038890
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N09742f28e6aa4ce2ad096bb1589e1c88 schema:name dimensions_id
81 schema:value pub.1032828853
82 rdf:type schema:PropertyValue
83 N0fc9e342fe614ab89c634274aea313af rdf:first sg:person.01156734301.76
84 rdf:rest rdf:nil
85 N454c8ccb4b6649a39968a2fcb50a1587 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Skull Base Neoplasms
87 rdf:type schema:DefinedTerm
88 N45dc5df13be748c6b40ecc80187ebd48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Radiotherapy, Conformal
90 rdf:type schema:DefinedTerm
91 N5db4b9a24bee43c488de263a1017ba2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Spinal Neoplasms
93 rdf:type schema:DefinedTerm
94 N8394eb915d354697aa0f7e0ebb7c7cf5 rdf:first sg:person.0637022555.52
95 rdf:rest N0fc9e342fe614ab89c634274aea313af
96 N8a4caeaf817a46a5971017f6a39cea56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Protons
98 rdf:type schema:DefinedTerm
99 N98fdd027dae841db82450832735580ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Humans
101 rdf:type schema:DefinedTerm
102 Na6184441a5cc462ab22675b22bf9a305 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Proton Therapy
104 rdf:type schema:DefinedTerm
105 Na681e02b7c7d46ddb633f83e79c36ebe schema:name doi
106 schema:value 10.1007/bf03038890
107 rdf:type schema:PropertyValue
108 Na93504513fbd44d7ae1431328641f8ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Magnetic Resonance Imaging
110 rdf:type schema:DefinedTerm
111 Nb46b9ca2f92847b2ab3db32874976440 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 Nb648bc573f5044568c982b6005327579 schema:volumeNumber 175
114 rdf:type schema:PublicationVolume
115 Nb6ad4237f89348ada676c9c7d9aa8a38 schema:name pubmed_id
116 schema:value 10394399
117 rdf:type schema:PropertyValue
118 Nbae3a63f58244d1997c57930210c0abd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Radiotherapy Planning, Computer-Assisted
120 rdf:type schema:DefinedTerm
121 Nbeed96e1b3f14457bc1546e14727e66a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Chordoma
123 rdf:type schema:DefinedTerm
124 Nc2b3154a164245a8a5a7f46558edc8dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Chondrosarcoma
126 rdf:type schema:DefinedTerm
127 Nc30cfe6658ce489a81a6153a8f1baafa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Tomography, X-Ray Computed
129 rdf:type schema:DefinedTerm
130 Nd30537f93b404a88bae2e6d0ba2caf81 schema:issueNumber Suppl 2
131 rdf:type schema:PublicationIssue
132 Nd5bb37af4c6149f59ac3f4d805333efd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Female
134 rdf:type schema:DefinedTerm
135 Ndbfce3fc32b14dc9a0f997c9ffd54f85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Male
137 rdf:type schema:DefinedTerm
138 Nffdbe49172994ac283a8585766b0f4d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Radiotherapy, Computer-Assisted
140 rdf:type schema:DefinedTerm
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
145 schema:name Clinical Sciences
146 rdf:type schema:DefinedTerm
147 sg:grant.2435408 http://pending.schema.org/fundedItem sg:pub.10.1007/bf03038890
148 rdf:type schema:MonetaryGrant
149 sg:journal.1054450 schema:issn 0179-7158
150 1439-099X
151 schema:name Strahlentherapie und Onkologie
152 schema:publisher Springer Nature
153 rdf:type schema:Periodical
154 sg:person.01156734301.76 schema:affiliation grid-institutes:grid.38142.3c
155 schema:familyName Liebsch
156 schema:givenName Norbert J.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156734301.76
158 rdf:type schema:Person
159 sg:person.0637022555.52 schema:affiliation grid-institutes:grid.38142.3c
160 schema:familyName Munzenrider
161 schema:givenName John E.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637022555.52
163 rdf:type schema:Person
164 grid-institutes:grid.38142.3c schema:alternateName Department of Radiation Oncology, Massachusett General Hospital, Harvard University Medical School, 02115, Boston, MA, USA
165 schema:name Department of Radiation Oncology, Massachusett General Hospital, Harvard University Medical School, 02115, Boston, MA, USA
166 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...