Nitrous oxide potentiates vecuronium neuromuscular blockade in humans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1991-10

AUTHORS

P. Fiset, P. Balendran, D. R. Bevan, F. Donati

ABSTRACT

This study was designed to measure the potency of vecuronium with and without nitrous oxide. Anaesthesia was induced with thiopentone and fentanyl in 56 adult patients. The subjects were randomly assigned to receive nitrous oxide, 70%, or intermittent boluses of thiopentone and fentanyl for maintenance of anaesthesia. Train-of-four stimulation was applied to the ulnar nerve every 20 sec, and the force of contraction of the adductor pollicis muscle was measured. Vecuronium, 20, 30 or 40 μg·kg−1 was given by random allocation five minutes after induction of anaesthesia. Maximum depression of the first response (T1) in the train-of-four was measured, and dose— response curves were constructed. In the absence of nitrous oxide, the ED50 and ED95 were mean ± standard error of the mean (SEM), 29.2±1.8 and 59.3±3.6 μg·kg−, respectively. In the group receiving nitrous oxide, these values were 25.3 ±1.2 and 42.3±2.0 μg· kg−1 respectively. By analysis of covariance, the dose-response curves were shown to be shifted with respect to one another (P<0.05). Administration of nitrous oxide was associated with a 19.5% increase in potency (95% confidence limits: 1.7 to 40.4%). It is concluded that nitrous oxide has a slight potentiating effect on neuromuscular blockade, and that this effect occurs within five to ten minutes after the beginning of its administration. More... »

PAGES

866-869

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03036961

DOI

http://dx.doi.org/10.1007/bf03036961

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030787929

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1683819


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