Génotoxicité des chimiothérapies et radiothérapies: Quelles sont les conséquences pour le spermatozoïde humain? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-09

AUTHORS

Louis Bujan, Philippe De Mas

ABSTRACT

Le pronostic des cancers de l’homme jeune en âge de procréer s’est considérablement amélioré ces dernières décades grâce aux progrès thérapeutiques. Les chimiothérapies et radiothérapies ont des effets bien connus sur la spermatogenèse. Au dela de l’atteinte quantative et qualitative de la spermatogenèse, des études réalisées chez l’animal ont pu mettre en évidence des atteintes nucléaires (aneuploïdie, présence d’adduits, fragmentation de l’ADN…) et parfois des atteintes au niveau des générations F1 et F2. Chez l’homme, l’étude des chromosomes des spermatozoïdes après radiothérapie a mis en évidence une augmentation de la fréquence des anomalies chromosomiques. Concernant la chimiothérapie, les premières études utilisaient la technique de fécondation hétérospécifique pour mettre en évidence les anomalies chromosomiques du spermatozoïde. Plus récemment, la technique d’hybridation de sondes chromosomiques fluorescentes (FISH) permet d’étudier plusieurs chromosomes sur un grand nombre de spermatozoides. Les résultats des différentes études portant sur des effectifs réduits sont variables en fonction du protocole thérapeutique administré et de la durée séparant le prélèvement de la fin du traitement. Nous avons étudié 5 patients ayant fait un prélèvement de sperme 6 à 17 mois après le protocole de chimiothérapie BEP (Bléomycin, Etoposide, Cisplatin). Nous avons mis en évidence une augmentation du taux de spermatozoïdes présentant une aneuploïdie et une diploïdie. Les résultats de notre étude et de celles du groupe de R. Martin [45, 47] évoquent la possibilité d’un effet transitoire de la chimiothérapie sur les chromosomes gamétiques. Dans le cadre de la maladie de Hodgkin d’autres études ont mis en évidence l’aspect transitoire de l’effet sur l’aneuploïdie. Au dela de l’atteinte chromosomique, l’action délétère des traitements pourrait avoir pour cible l’ADN du spermatozoïde. Ainsi des études sur des effectifs importants, utilisant d’autres métodes d’analyse nous parraissent nécessaires. Dans l’attente, il paraît souhaitable de toujours conseiller l’autoconservation de sperme avant les traitements et d’adopter une grande prudence lors du conseil apporté aux patients désirant une grossesse, précocément, après la fin des traitements. More... »

PAGES

284-294

Journal

TITLE

Andrologia

ISSUE

3

VOLUME

12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03035141

DOI

http://dx.doi.org/10.1007/bf03035141

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031970743


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