Chimiothérapie anticancéreuse et fertilité masculine View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1995-12

AUTHORS

C. Chevreau, F. Huguet

ABSTRACT

Parmi les agents anti-cancéreux, ceux qui interagissent directement avec l'ADN sont les plus toxiques pour les cellules de la lignée germinale. L'atteinte de ces cellules est essentiellement le fait des agents alkylants dont la toxicité est dose-dépendante. La rapidité et la qualité de récupération de la spermatogénèse est essentiellement fonction de la sévérité de l'atteinte des spermatogonies souches. Les études expérimentales conduites chez la souris et le rat ont permis de progresser dans la connaissance des mécanismes de la toxicité germinale des agents cytotoxiques, mais ces données ne sont pas toujours superposables à celles observées en clinique. Les études ont essentiellement été conduites chez les patients porteurs de tumeurs germinales du testicule ou de maladie de Hodgkin. Du fait de leur curabilité potentielle et de leur fréquente survenue chez le sujet jeune, elles représentent en effet les situations cliniques dans lesquelles il est essentiel d'essayer de préserver la fertilité du sujet. Le choix des protocoles chimiothérapiques les moins toxiques pour la lignée germinale, à résultat thérapeutique équivalent, est actuellement un moyen de réduire au maximum le risque d'azoospermie définitive. Ce risque n'est cependant jamais nul justifiant le recours systématique à l'auto-conservation de gamètes avant toute chimiothérapie chez un sujet susceptible de développer un projet de paternité. More... »

PAGES

458-464

References to SciGraph publications

  • 1992-05. Effects of carboplatin on the testis in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1987-05. Reproductive and endocrine gonadal capacity in patients treated with COPP chemotherapy for Hodgkin's disease in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Journal

    TITLE

    Andrologia

    ISSUE

    4

    VOLUME

    5

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf03034529

    DOI

    http://dx.doi.org/10.1007/bf03034529

    DIMENSIONS

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