Comparative toxicity of isoflurane, halothane, fluroxene and diethyl ether in human volunteers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1973-05

AUTHORS

Wendell C. Stevens, E. I. Eger, Thomas A. Joas, Thomas H. Cromwell, Anne White, William M. Dolan

ABSTRACT

Comparisons of toxic effects of isoflurane, halothane, fluroxene and diethyl ether were made in human volunteers not undergoing surgical procedures. Comparisons were made of effects on bromsulpthalein retention, serum glutamic oxaloacetic and pyruvic transaminases, lactic dehydrogenase, alkaline phosphatase, serum cholesterol, total serum protein and albumin, serum sodium, chloride, potassium, carbon dioxide content, uric acid, calcium, phosphorus, glucose, creatinine, fluoride, blood urea nitrogen, urine and plasma lysozymes, haematocrit, white blood cells, polymorphonuclear leukocytes and urinalysis. We found greater increases in BSP after halothane and fluroxene than after isoflurane. Concomitant hypercapnia or hypotension did not influence the results. Serum glutamic oxaloacetic transaminase increased only after fluroxene. We found elevated polymorphonuclear leukocytes after all anaesthetics. No serious toxicity occurred after any of the anaesthetics. More... »

PAGES

357-368

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03027173

DOI

http://dx.doi.org/10.1007/bf03027173

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030525870

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4145114


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