Ontology type: schema:ScholarlyArticle
2002-07
AUTHORSC. Senore, Paola Armaroli, N. Segnan
ABSTRACTEndoscopic screening represents a promising approach to secondary prevention of colorectal cancer in the general population. Accumulated evidence concerning the role of the sequence adenoma-carcinoma in the development of colorectal cancer supports the hypothesis that endoscopic excision of adenomas might result in the prevention of cancer. Observational studies consistently showed a substantial reduction of incidence and mortality for colorectal cancer among subjects who reported having performed previous endoscopic exams. Two tests have been proposed: sigmoidoscopy and colonoscopy. We discuss a series of issues, related to the performance of the tests, side effects, neoplasia yield and compliance, which might influence the feasibility of a mass screening intervention. We conclude that the proposed tests are not equivalent. The expected increase in the protective effect which can be achieved using colonoscopy should be balanced with the higher complication rate, as well as with the increase in the need of resources, in terms of monetary costs, manpower and expertise. More... »
PAGES593-621
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