Successful treatment using recombinant factor VIIa for severe bleeding post cardiopulmonary bypass View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-06

AUTHORS

Viren N. Naik, C. David Mazer, David A. Latter, Jerome M. Teitel, Gregory M. T. Hare

ABSTRACT

PURPOSE: To describe a case of persistent and excessive bleeding following an aortic valve and ascending aorta replacement that was successfully managed with recombinant factor VIIa (rFVIIa). The postulated mechanisms for rFVIIa are discussed. CLINICAL FEATURES: A 75-yr-old female with no preoperative coagulopathy underwent a tissue aortic valve replacement and supracoronary ascending aorta replacement for severe aortic stenosis and an ascending aortic aneurysm. Following surgery, she bled in excess of 200 mL x hr(-1) despite a nearly normal platelet count and nearly normal coagulation parameters. The patient was surgically re-explored twice in seven hours, and despite the presence of near normal in vitro coagulation parameters, the patient continued to bleed. Multiple units of fresh frozen plasma, platelets and cryoprecipitate were administered empirically. We then administered a single 6-mg (107 microg x kg(-1)) iv dose of rFVIIa. Following the administration of rFVIIa, blood loss decreased to a total of 440 mL over the next 12 hr. CONCLUSIONS: This case describes the use of rFVIIa for intractable bleeding postcardiovascular surgery in the presence of nearly normal laboratory markers of coagulation. Further controlled laboratory and clinical studies are required to define the role of rFVIIa in patients undergoing cardiovascular surgery. More... »

PAGES

599-602

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03018648

DOI

http://dx.doi.org/10.1007/bf03018648

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047554272

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12826554


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