Five percent, 7.5% or 10% hypertonic saline prevents delayed neuronal death in gerbils View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-08

AUTHORS

Shinsuke Hamaguchi, Yasuhisa Okuda, Toshimitsu Kitajima, Nobuhide Masawa

ABSTRACT

PurposeTo clarify the appropriate concentration and dose of hypertonic saline solution (HSS) for preventing delayed neuronal death in the hippocampal CAI subfield after transient forebrain ischemia in gerbils.MethodsThirty gerbils were randomly assigned to five groups: physiological saline solution (PSS) group, ischemia/reperfusion treated with PSS 2 mL·kg−1; 5% HSS group, treated with 5% HSS 2 mL·kg−1; 7.5% HSS group, treated with 7.5% HSS 2 mL·kg−1; 10% HSS group, treated with 10% HSS 2 mL·kg−1; 20% HSS group, treated with 20% HSS 2 mL·kg−1. Transient forebrain ischemia was induced by occluding the bilateral common carotid arteries for four minutes. Five days later, histopathological changes in the hippocampal area were examined, and the degenerative ratio of the pyramidal cells were measured according to the following formula: (number of degenerative pyramidal cells/total number of pyramidal cells per 1 mm of hippocampal CAI subfield) × 100.ResultsIn PSS and 20% groups, neuronal cell damage was observed five days after ischemia. In the other three groups, these changes were not observed. The degenerative ratios of pyramidal cells were as follows; PSS group: 9 1.6 ± 5.6%, 5% HSS group: 7.2 ± 1.6%, 7.5% group: 8.3 ± 1.4%, 10% HSS group: 6.2 ± 1.1%, 20% HSS group: 85.8 ± 8.7% (P < 0.05; PSS and 20% HSSvs three other groups).ConclusionThis study demonstrates that 5, 7.5 or 10% HSS 2 mL·kg−1 may prevent delayed neuronal death in the hippocampal CAI subfield after cerebral ischemia/reperfusion in gerbils. More... »

PAGES

745-748

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03017456

DOI

http://dx.doi.org/10.1007/bf03017456

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038030112

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12193496


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