RETRACTED ARTICLE: Urapidil does not prevent postanesthetic shivering: a dose-ranging study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-09

AUTHORS

Swen N. Piper, Moritz T. Fent, Kerstin D. Röhm, Wolfgang H. Maleck, Stefan W. Suttner, Joachim Boldt

ABSTRACT

PURPOSE: To investigate the effect of 0.2 mg x kg(-1), 0.3 mg x kg(-1) and 0.4 mg x kg(-1) urapidil on the incidence and severity of postanesthetic shivering. METHODS: One hundred and fifty patients (ASA I-III) scheduled for elective abdominal, urologic or orthopedic surgery under standardized general anesthesia were randomly allocated to one of five groups (each group n=30) using a double-blind protocol: group A received 0.2 mg x kg(-1) urapidil, group B: 0.3 mg x kg(-1) urapidil, group C: 0.4 mg x kg(-1) urapidil, group D: 3 microg x kg(-1) clonidine (positive control group), and group E: saline 0.9% as placebo (negative control group). Postanesthetic shivering was scored using a five-point scale. RESULTS: Twelve patients of group A, 11 of group B, nine of group C, three of group D and 14 of group E showed signs of postanesthetic shivering. Postanesthetic shivering was significantly decreased in the clonidine group compared to the three urapidil groups and the placebo group. Significantly less patients treated with clonidine needed anti-shivering therapy. There were no significant differences between the urapidil and placebo groups. Therapeutic interventions for hemodynamic effects were not required in any group. Time to extubation, but not time to discharge, was prolonged in the clonidine group. CONCLUSION: Urapidil showed no beneficial effect on shivering in any of the doses evaluated, whereas prophylactic administration of clonidine was effective in preventing postanesthetic shivering. More... »

PAGES

742-747

References to SciGraph publications

  • 1997-03. Clonidine at induction reduces shivering after general anaesthesia in JOURNAL CANADIEN D'ANESTHÉSIE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf03016688

    DOI

    http://dx.doi.org/10.1007/bf03016688

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005265143

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11546713


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