Analgésie, l’importance du polymorphisme génétique du cytochrome P450 2D6 dans l’individualisation thérapeutique View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-06

AUTHORS

C. F. Samer, V. Piguet, P. Dayer, J. A. Desmeules

ABSTRACT

Most currently used analgesics are metabolised by polymorphic cytochromes P450 (CYP) isoenzymes, among others CYP2D6. Clinical consequences of administering standard drug regimen metabolised by these isoenzymes could range from drug toxicity to lack of therapeutic effect, depending on the drug and polymorphism. By screening such polymorphisms through genotyping and phenotyping, pharmacogenetic will enable to anticipate analgesic drug approach. It could consequently improve the safety and efficiency of individualized drug prescriptions. More... »

PAGES

63

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03012809

DOI

http://dx.doi.org/10.1007/bf03012809

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030181830


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