Advances in oral anti arrhythmic therapy: implications for the anaesthetist View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-01

AUTHORS

Warner J. Lucas, Gerald A. Maccioli, Robert A. Mueller

ABSTRACT

Surgical patients often are receiving antiarrhythmic therapy. Thus, because anaesthetic agents can affect cardiac function and may interact with concurrent antiarrhythmic medications, the anaesthetist should be aware of the electrophysiology associated with dysrhythmias and their management. Tocainide, flecainide, mexiletine, encainide and amiodarone have been introduced recently and each has an unique pattern of bioavailability, metabolism and toxicity. Patients treated with these drugs need special concern as they have abnormal cardiovascular systems and may be at increased risk for perioperative morbidity. In addition, unexpected untoward reactions and toxicity can result from interactions of anaesthetic agents and these drugs. This review discusses normal cardiac electrophysiology, common dysrhythmias and the electrophysiological effects of the newer oral antiarrhythmic drugs. More... »

PAGES

94-101

References to SciGraph publications

  • 1985-06. Mexiletine kinetics in healthy subjects taking cimetidine in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1978-11. The absorption of oral mexiletine in coronary care patients in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1983-08. Tocainide in DRUGS
  • 1985-05. Long Term Use of Flecainide in Patients with Supraventricular Tachycardia in DRUGS
  • 1985-01. Flecainide in DRUGS
  • 1984-04. Clinical Pharmacokinetics of Amiodarone in CLINICAL PHARMACOKINETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf03007489

    DOI

    http://dx.doi.org/10.1007/bf03007489

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2403852


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