Cell-mediated immune suppression due to alfathesin in short-term anaesthesia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1983-09

AUTHORS

A. Rosenfeld, Z. T. Handzel, S. Konichezky, S. Levin, D. Soroker

ABSTRACT

The immunosuppressive effects on cell-mediated immunity of alfathesin, when used as the sole agent for short-term anaesthesia, were investigated in ten women undergoing pregnancy termination. Cell-mediated immunity was evaluated by E rosette formation in peripheral blood (reflecting the percentage of T lymphocytes) and by proliferative responses to the mitogens concanavalin A and phyto-haemagglutinin in various concentrations. Measurements were made before alfathesin was administered, and again after 60 minutes, two days and seven days. Significant reductions in the percentage of E rosettes in peripheral blood and in mitogenic responses to concanavalin A were observed 60 minutes after administration of alfathesin. A model is proposed in which alfathesin binds to lymphocytic membrane receptors, thus affecting in vitro cell-mediated immune reactions. More... »

PAGES

522-525

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf03007088

DOI

http://dx.doi.org/10.1007/bf03007088

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018960862

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6627071


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