In vivo nephrotoxicity induced in mice by chromium(VI) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-10

AUTHORS

Yasuji Hojo, Yoshiko Satomi

ABSTRACT

The role of glutathione (GSH) and chromium (V) in chromium (VI)-induced nephrotoxicity in mice was investigated at 24 h after K2Cr(VI)2O7 ip injection. Nephrotoxicity was assessed by measurements of relative kidney weight and serum urea nitrogen. Cr(VI) nephrotoxicity was accompanied by decreased renal GSH and glutathione reductase (GSSG-R) levels. Pretreatment with buthionine sulfoximine, an inhibitor of GSH biosynthesis, enhanced Cr(VI)-induced nephrotoxicity, and remarkably diminished kidney GSH and GSSG-R levels. In contrast, pretreatment with glutathione methyl ester, a GSH-supplying agent, prevented Cr(VI) from exerting a harmful effect on mouse kidney and restored kidney GSH level. Administration of a Cr(V) compound, K3Cr(V)O8, induced much higher toxicity in mouse kidney than Cr(VI), but it failed to diminish renal GSH level. Another Cr(V) compound, Cr(V)-GSH complex, and Cr(III) nitrate did not cause a nephrotoxic effect in mice. The mechanism of Cr(VI)-induced nephrotoxicity was explained using GSH and Cr(V). More... »

PAGES

21-31

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02990356

DOI

http://dx.doi.org/10.1007/bf02990356

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027894577

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1724173


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electron Spin Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutathione", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutathione Reductase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidation-Reduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peroxides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Potassium Dichromate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfhydryl Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urea", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratory of Environmental Health and Toxicology, Department of Food Science and Nutrition, Kyoto Prefectural University, 606, Shimogamo, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258797.6", 
          "name": [
            "Laboratory of Environmental Health and Toxicology, Department of Food Science and Nutrition, Kyoto Prefectural University, 606, Shimogamo, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hojo", 
        "givenName": "Yasuji", 
        "id": "sg:person.01173546402.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173546402.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Environmental Health and Toxicology, Department of Food Science and Nutrition, Kyoto Prefectural University, 606, Shimogamo, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258797.6", 
          "name": [
            "Laboratory of Environmental Health and Toxicology, Department of Food Science and Nutrition, Kyoto Prefectural University, 606, Shimogamo, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Satomi", 
        "givenName": "Yoshiko", 
        "type": "Person"
      }
    ], 
    "datePublished": "1991-10", 
    "datePublishedReg": "1991-10-01", 
    "description": "The role of glutathione (GSH) and chromium (V) in chromium (VI)-induced nephrotoxicity in mice was investigated at 24 h after K2Cr(VI)2O7 ip injection. Nephrotoxicity was assessed by measurements of relative kidney weight and serum urea nitrogen. Cr(VI) nephrotoxicity was accompanied by decreased renal GSH and glutathione reductase (GSSG-R) levels. Pretreatment with buthionine sulfoximine, an inhibitor of GSH biosynthesis, enhanced Cr(VI)-induced nephrotoxicity, and remarkably diminished kidney GSH and GSSG-R levels. In contrast, pretreatment with glutathione methyl ester, a GSH-supplying agent, prevented Cr(VI) from exerting a harmful effect on mouse kidney and restored kidney GSH level. Administration of a Cr(V) compound, K3Cr(V)O8, induced much higher toxicity in mouse kidney than Cr(VI), but it failed to diminish renal GSH level. Another Cr(V) compound, Cr(V)-GSH complex, and Cr(III) nitrate did not cause a nephrotoxic effect in mice. The mechanism of Cr(VI)-induced nephrotoxicity was explained using GSH and Cr(V).", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf02990356", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1090652", 
        "issn": [
          "0163-4984", 
          "1559-0720"
        ], 
        "name": "Biological Trace Element Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "keywords": [
      "mouse kidney", 
      "relative kidney weight", 
      "GSH levels", 
      "kidney GSH levels", 
      "serum urea nitrogen", 
      "renal GSH levels", 
      "glutathione reductase levels", 
      "kidney weight", 
      "kidney GSH", 
      "nephrotoxic effects", 
      "renal GSH", 
      "ip injection", 
      "nephrotoxicity", 
      "urea nitrogen", 
      "vivo nephrotoxicity", 
      "role of glutathione", 
      "mice", 
      "buthionine sulfoximine", 
      "kidney", 
      "reductase levels", 
      "harmful effects", 
      "GSH", 
      "pretreatment", 
      "levels", 
      "administration", 
      "injection", 
      "methyl ester", 
      "inhibitors", 
      "toxicity", 
      "GSH biosynthesis", 
      "high toxicity", 
      "effect", 
      "glutathione", 
      "sulfoximine", 
      "agents", 
      "GSSG", 
      "weight", 
      "role", 
      "contrast", 
      "mechanism", 
      "compounds", 
      "esters", 
      "biosynthesis", 
      "measurements", 
      "complexes", 
      "chromium", 
      "nitrate", 
      "nitrogen", 
      "glutathione methyl ester"
    ], 
    "name": "In vivo nephrotoxicity induced in mice by chromium(VI)", 
    "pagination": "21-31", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027894577"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02990356"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1724173"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02990356", 
      "https://app.dimensions.ai/details/publication/pub.1027894577"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_244.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf02990356"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02990356'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02990356'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02990356'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02990356'


 

This table displays all metadata directly associated to this object as RDF triples.

185 TRIPLES      21 PREDICATES      93 URIs      85 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf02990356 schema:about N06dfcc4e08ed4971b8411fc679f6ff63
2 N20c26e99f44f49419532b51b9fb83f69
3 N23203939f2624c1d847f32a5667bb842
4 N23fc4371a9694fea8cade86e09d9d8b4
5 N40c3dda24bc047a79b3ca42a5ea53673
6 N44a81b3924e14a3a96e4d7a7dc9ea820
7 N60cf4f1bbcd04a91aa56119d04c9c321
8 N7b76371b76a24d469f218f80a2e7d8f9
9 N8381a493af10449bbb11e93c27075b96
10 N8e2c532d289e417ea83cffd49a90e632
11 N902ebd266b964a638c6cc598c73bdae8
12 N93d635d2cb37439bb8973d3c3c046988
13 N95eec3e30ef349f98415cfee8bd00211
14 Na495d7690853445ab02cbb0d158ecb93
15 Nbd46ae5bb06e4d199514403399e1e339
16 Ne817aa1f512248c9bc89b003ef4f003a
17 Necc330c1d4a749b381baf69b2ae11375
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N0617aec5e1b54972819a5f3587cefca3
21 schema:datePublished 1991-10
22 schema:datePublishedReg 1991-10-01
23 schema:description The role of glutathione (GSH) and chromium (V) in chromium (VI)-induced nephrotoxicity in mice was investigated at 24 h after K2Cr(VI)2O7 ip injection. Nephrotoxicity was assessed by measurements of relative kidney weight and serum urea nitrogen. Cr(VI) nephrotoxicity was accompanied by decreased renal GSH and glutathione reductase (GSSG-R) levels. Pretreatment with buthionine sulfoximine, an inhibitor of GSH biosynthesis, enhanced Cr(VI)-induced nephrotoxicity, and remarkably diminished kidney GSH and GSSG-R levels. In contrast, pretreatment with glutathione methyl ester, a GSH-supplying agent, prevented Cr(VI) from exerting a harmful effect on mouse kidney and restored kidney GSH level. Administration of a Cr(V) compound, K3Cr(V)O8, induced much higher toxicity in mouse kidney than Cr(VI), but it failed to diminish renal GSH level. Another Cr(V) compound, Cr(V)-GSH complex, and Cr(III) nitrate did not cause a nephrotoxic effect in mice. The mechanism of Cr(VI)-induced nephrotoxicity was explained using GSH and Cr(V).
24 schema:genre article
25 schema:inLanguage en
26 schema:isAccessibleForFree false
27 schema:isPartOf N18a38f4d51234b63a7a5c3d99a2ef522
28 N8a8e247e75134d5384ab0695c4370947
29 sg:journal.1090652
30 schema:keywords GSH
31 GSH biosynthesis
32 GSH levels
33 GSSG
34 administration
35 agents
36 biosynthesis
37 buthionine sulfoximine
38 chromium
39 complexes
40 compounds
41 contrast
42 effect
43 esters
44 glutathione
45 glutathione methyl ester
46 glutathione reductase levels
47 harmful effects
48 high toxicity
49 inhibitors
50 injection
51 ip injection
52 kidney
53 kidney GSH
54 kidney GSH levels
55 kidney weight
56 levels
57 measurements
58 mechanism
59 methyl ester
60 mice
61 mouse kidney
62 nephrotoxic effects
63 nephrotoxicity
64 nitrate
65 nitrogen
66 pretreatment
67 reductase levels
68 relative kidney weight
69 renal GSH
70 renal GSH levels
71 role
72 role of glutathione
73 serum urea nitrogen
74 sulfoximine
75 toxicity
76 urea nitrogen
77 vivo nephrotoxicity
78 weight
79 schema:name In vivo nephrotoxicity induced in mice by chromium(VI)
80 schema:pagination 21-31
81 schema:productId N38b59b6ccfa34095baefa9468814e928
82 N3ddd39f6fda246f2845f1b1d571d8653
83 Na024607b0f66486db65ca6c54d9b73c5
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027894577
85 https://doi.org/10.1007/bf02990356
86 schema:sdDatePublished 2022-01-01T18:06
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher Na72174d744f242028548fd894fe19443
89 schema:url https://doi.org/10.1007/bf02990356
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N0617aec5e1b54972819a5f3587cefca3 rdf:first sg:person.01173546402.09
94 rdf:rest N1dbacaa533ea475eb9bdb3295681119b
95 N06dfcc4e08ed4971b8411fc679f6ff63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Kidney
97 rdf:type schema:DefinedTerm
98 N18a38f4d51234b63a7a5c3d99a2ef522 schema:volumeNumber 31
99 rdf:type schema:PublicationVolume
100 N1dbacaa533ea475eb9bdb3295681119b rdf:first N3314eafed5a0463cbd353e809cc76d64
101 rdf:rest rdf:nil
102 N20c26e99f44f49419532b51b9fb83f69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Urea
104 rdf:type schema:DefinedTerm
105 N23203939f2624c1d847f32a5667bb842 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Peroxides
107 rdf:type schema:DefinedTerm
108 N23fc4371a9694fea8cade86e09d9d8b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Electron Spin Resonance Spectroscopy
110 rdf:type schema:DefinedTerm
111 N3314eafed5a0463cbd353e809cc76d64 schema:affiliation grid-institutes:grid.258797.6
112 schema:familyName Satomi
113 schema:givenName Yoshiko
114 rdf:type schema:Person
115 N38b59b6ccfa34095baefa9468814e928 schema:name dimensions_id
116 schema:value pub.1027894577
117 rdf:type schema:PropertyValue
118 N3ddd39f6fda246f2845f1b1d571d8653 schema:name doi
119 schema:value 10.1007/bf02990356
120 rdf:type schema:PropertyValue
121 N40c3dda24bc047a79b3ca42a5ea53673 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Body Weight
123 rdf:type schema:DefinedTerm
124 N44a81b3924e14a3a96e4d7a7dc9ea820 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Male
126 rdf:type schema:DefinedTerm
127 N60cf4f1bbcd04a91aa56119d04c9c321 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Chromates
129 rdf:type schema:DefinedTerm
130 N7b76371b76a24d469f218f80a2e7d8f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Potassium Dichromate
132 rdf:type schema:DefinedTerm
133 N8381a493af10449bbb11e93c27075b96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Chromium
135 rdf:type schema:DefinedTerm
136 N8a8e247e75134d5384ab0695c4370947 schema:issueNumber 1
137 rdf:type schema:PublicationIssue
138 N8e2c532d289e417ea83cffd49a90e632 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Organ Size
140 rdf:type schema:DefinedTerm
141 N902ebd266b964a638c6cc598c73bdae8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Glutathione
143 rdf:type schema:DefinedTerm
144 N93d635d2cb37439bb8973d3c3c046988 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Animals
146 rdf:type schema:DefinedTerm
147 N95eec3e30ef349f98415cfee8bd00211 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Oxidation-Reduction
149 rdf:type schema:DefinedTerm
150 Na024607b0f66486db65ca6c54d9b73c5 schema:name pubmed_id
151 schema:value 1724173
152 rdf:type schema:PropertyValue
153 Na495d7690853445ab02cbb0d158ecb93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Kidney Diseases
155 rdf:type schema:DefinedTerm
156 Na72174d744f242028548fd894fe19443 schema:name Springer Nature - SN SciGraph project
157 rdf:type schema:Organization
158 Nbd46ae5bb06e4d199514403399e1e339 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Sulfhydryl Compounds
160 rdf:type schema:DefinedTerm
161 Ne817aa1f512248c9bc89b003ef4f003a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Glutathione Reductase
163 rdf:type schema:DefinedTerm
164 Necc330c1d4a749b381baf69b2ae11375 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Mice
166 rdf:type schema:DefinedTerm
167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
168 schema:name Medical and Health Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
171 schema:name Clinical Sciences
172 rdf:type schema:DefinedTerm
173 sg:journal.1090652 schema:issn 0163-4984
174 1559-0720
175 schema:name Biological Trace Element Research
176 schema:publisher Springer Nature
177 rdf:type schema:Periodical
178 sg:person.01173546402.09 schema:affiliation grid-institutes:grid.258797.6
179 schema:familyName Hojo
180 schema:givenName Yasuji
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173546402.09
182 rdf:type schema:Person
183 grid-institutes:grid.258797.6 schema:alternateName Laboratory of Environmental Health and Toxicology, Department of Food Science and Nutrition, Kyoto Prefectural University, 606, Shimogamo, Kyoto, Japan
184 schema:name Laboratory of Environmental Health and Toxicology, Department of Food Science and Nutrition, Kyoto Prefectural University, 606, Shimogamo, Kyoto, Japan
185 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...