Parenteral supplementation with zinc in surgical patients corrects postoperative serum-zinc drop View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-07

AUTHORS

Henri Faure, Jean-Claude Peyrin, Marie-Jeanne Richard, Alain Favier

ABSTRACT

Zinc has been known for a long time to facilitate wound healing. But, so far, supplementation trials in patients treated by major severity surgery gave either partial or controversial results. In a double-blind, randomized study including 30 patients, we show that zinc supplements (30 mg/d for 3 d) administered by a drip correct postoperative drop of serum zinc, that this correction concerns the available part of serum zinc (i.e., zinc that is bound to compounds other than alpha-2 macroglobulin in serum), and that this supplementation can improve clinical wound healing. Possible influence of increased urinary output after the intervention is discussed, and we found that serum cortisol remains stable when zinc/albumin ratio is stable, and increases sharply when the same ratio drops. Cortisol, therefore, seems to play a major role in zinc redistribution after surgery. More... »

PAGES

37-45

References to SciGraph publications

  • 1989. Putative Therapeutic Roles for Zinc in ZINC IN HUMAN BIOLOGY
  • 1990-01. Determination of the major zinc fractions in human serum by ultrafiltration in BIOLOGICAL TRACE ELEMENT RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02990340

    DOI

    http://dx.doi.org/10.1007/bf02990340

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005380413

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1718367


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