Methotrexate, vinblastine, epidoxorubicin and cisplatin (M-VEC) in patients with locally advanced transitional bladder cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-06

AUTHORS

A. Frassoldati, M. Federico, F. Barbieri, M. Brausi, C. Pollastri, G. Berri, G. Castagnetti, P. P. Palladini, V. Silingardi

ABSTRACT

M-VEC (methotrexate, vinblastine, epidoxorubicin and cisplatin), a new combined drug regimen in which epidoxorubicin has been substituted to adriamycin to reduce the toxicity of the original M-VAC chemotherapy, has been tested in 23 patients with locally advanced transitional cell bladder cancer (TCBC) (stage T2-T4 No Mo). After two to four courses, an objective response was observed in 19 patients, with 13 clinical complete responses. Seven patients underwent cystectomy after chemotherapy: one patient had no residual tumor on bladder specimens, five patients had a surgical eradication of the disease, while one patient had only a partial resection. Eight relapses of bladder carcinoma were observed, three among the surgically treated patients and five among patients who did not undergo cystectomy, with a median time-to-relapse of 9.7 months. Progression-free survival at 24 months was 52.3%. M-VEC regimen appears to be effective in locally advanced TCBC, with acceptable toxicity. More... »

PAGES

99-103

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02988861

DOI

http://dx.doi.org/10.1007/bf02988861

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1077416518

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1749307


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