From tumor biology to clinical PET: A review of positron emission tomography (PET) in oncology View Full Text


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Article Info

DATE

2001-12

AUTHORS

Kazuo Kubota

ABSTRACT

Cancer cells show increased metabolism of both glucose and amino acids, which can be monitored with18F-2-deoxy-2-fluoro-d-glucose (FDG), a glucose analogue, and11C-l-methionine (Met), respectively. FDG uptake is higher in fast-growing than in slow-growing tumors. FDG uptake is considered to be a good marker of the grade of malignancy. Several studies have indicated that the degree of FDG uptake in primary lung cancer can be used as a prognostic indicator. Differential diagnosis of lung tumors has been studied extensively with both computed tomography (CT) and positron emission tomography (PET). It has been established that FDG-PET is clinically very useful and that its diagnostic accuracy is higher than that of CT. Detection of lymph node or distant metastases in known cancer patients using a whole-body imaging technique with FDG-PET has become a good indication for PET. FDG uptake may be seen in a variety of tissues due to physiological glucose consumption. Also FDG uptake is not specific for cancer. Various types of active inflammation showed FDG uptake to a certain high level. Understanding of the physiological and benign causes of FDG uptake is important for accurate interpretation of FDG-PET.In monitoring radio/chemotherapy, changes in FDG uptake correlate with the number of viable cancer cells, whereas Met is a marker of proliferation. Reduction of FDG uptake is a sensitive marker of viable tissue, preceding necrotic extension and volumetric shrinkage. FDG-PET is useful for the detection of recurrence and for monitoring the therapeutic response of tumor tissues in various cancers, including those of the lung, colon, and head and neck. Thus, PET, particularly with FDG, is effective in monitoring cancer cell viability, and is clinically very useful for the diagnosis and detection of recurrence of lung and other cancers. More... »

PAGES

471-486

References to SciGraph publications

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  • 1999-09. Normal variants, artefacts and interpretative pitfalls in PET imaging with 18-fluoro-2-deoxyglucose and carbon-11 methionine in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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  • 1993-11. Fluorodeoxyglucose cell incorporation as an index of cell proliferation: evaluation of accuracy in cell culture in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1997-04. Rapid rise in FDG uptake in an irradiated human tumour xenograft in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1993-04. Carbon-11-methionine and PET in evaluation of treatment response of breast cancer in BRITISH JOURNAL OF CANCER
  • 1982-05. Methionine dependence in cancer cells — A review in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY
  • 2001-06. Physiological FDG uptake in the palatine tonsils in ANNALS OF NUCLEAR MEDICINE
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    http://scigraph.springernature.com/pub.10.1007/bf02988499

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    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11831394


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