The relative importance of principal and modifying genes in determining some human diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1941-01

AUTHORS

J. B. S. Haldane

ABSTRACT

Bell’s data on the age of onset of some human hereditary diseases are discussed. In glaucoma, peroneal atrophy, Friedreich’s ataxia, spastic ataxia, and spastic paraplegia, the age of onset in all affected members of a pedigree is nearly the same, while different pedigress differ widely. Thus a number of different main genes must be responsible for the clinically indistinguishable diseases in different families. In optic atrophy and Huntington’s chorea the differences of age of onset within a pedigree are nearly as large as those between different pedigrees. So the same main gene may be responsible for all cases, while modifying genes account for much of the difference in age of onset. The bearing of these facts on evolutionary theories is discussed. More... »

PAGES

149-157

Journal

TITLE

Journal of Genetics

ISSUE

2-3

VOLUME

41

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02983018

DOI

http://dx.doi.org/10.1007/bf02983018

DIMENSIONS

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