Transcriptional Regulation of Myelopoiesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-06

AUTHORS

Alan D. Friedman

ABSTRACT

A common myeloid progenitor gives rise to both granulocytes and monocytes. The early stages of granulopoiesis are mediated by the C/EBPalpha, PU.1, RAR, CBF, and c-Myb transcription factors, and the later stages require C/EBPepsilon, PU.1, and CDP. Monocyte development requires PU.1 and interferon consensus sequence binding protein and can be induced by Maf-B, c-Jun, or Egr-1. Cytokine receptor signals modulate transcription factor activities but do not determine cell fates. Several mechanisms orchestrate the myeloid developmental program, including cooperative gene regulation, protein:protein interactions, regulation of factor levels, and induction of cell cycle arrest. More... »

PAGES

466-472

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02982108

DOI

http://dx.doi.org/10.1007/bf02982108

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004483240

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12095145


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