Tratamiento adyuvante postoperatorio (braquiterapia +/- radioterapia externa) en pacientes con adenocarcinoma de endometrio. Análisis de 208 pacientes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-01

AUTHORS

J. López Torrecilla, P. Martínez, M. L. Chust, P. Carrasco, V. Crispín, L. Arribas, E. García

ABSTRACT

Valorar el control locorregional, supervivencia y complicaciones del tratamiento adyuvante postoperatorio en el adenocarcinoma de endometrio. Entre marzo de 1985 y diciembre de 1994, 208 pacientes con estadios I, II y III fueron tratadas después de la cirugía con braquiterapia en los estadios I de buen pronóstico, con radioterapia externa pélvica y braquiterapia en el resto de los estadios I y II, y con radioterapia abdóminopélvica y braquiterapia los estadios III. El seguimiento mínimo ha sido de 3 años. La supervivencia global y libre de enfermedad (SLE) a los 5 años fue del 88 y 89,6%, respectivamente. El grupo de pacientes con estadio IB (G1-G2) (46 pacientes) tratados con sólo braquiterapia después de la cirugía alcanzó una SLE del 97,8% a los 5 años, y un control locorregional del 100%. En el grupo tratado con radioterapia pélvica y braquiterapia la SLE a los 5 años fue del 86,9%, con una tasa de recidivas locorregionales del 3% (3/99). La SLE en el estadio IIIA llegó al 80% y la incidencia de fracasos abdominales fue del 19% (8/42). En el análisis multivariante la edad, el estadio y el grado de diferenciación fueron los factores que predijeron la SLE. Ocurrieron complicaciones en 28 pacientes (13,5%), siendo un 82,3% de ellas grado I. La braquiterapia postoperatoria es un tratamiento efectivo en la prevention de las recidivas locales en el grupo de pacientes con estadio I de buen pronóstico. La braquiterapia asociada a la radioterapia externa en los estadios I de mal pronóstico y II reduce la tasa de fracasos locorregionales al 3%. La SLE en el estadio IIIA tratado con radioterapia abdominopélvica alcanza el 80% a los 5 años. More... »

PAGES

23-32

Journal

TITLE

Clinical and Translational Oncology

ISSUE

1

VOLUME

2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02978298

DOI

http://dx.doi.org/10.1007/bf02978298

DIMENSIONS

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