Bioactive prenylated flavonoids from the stem bark ofartocarpus kemando View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-02

AUTHORS

Seo Eun-Kyoung, Lee Dongho, Shin Young Geun, Chai Hee-Byung, Hernan A. Navarro, Leonardus B. S. Kardono, Ismail Rahman, Geoffrey A. Cordell, Norman R. Farnsworth, John M. Pezzuto, A. Douglas Kinghorn, Mansukh C. Wani, Monroe E. Wall

ABSTRACT

Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic. More... »

PAGES

124

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02976656

DOI

http://dx.doi.org/10.1007/bf02976656

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035468006

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12643587


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