Cytotoxicity of a novel biphenolic compound, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane against human tumor cellsin vitro View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-08

AUTHORS

Sang Un Choi, Kwang Hee Kim, Nam Young Kim, Eun Jung Choi, Chong Ock Lee, Kwang Hee Son, Sung Uk Kim, Song Hae Bok, Young Kook Kim

ABSTRACT

Phenolic compounds are prevalent as toxins or environmental pollutants, but they are also widely used as drugs for various purpose including anticancer agent. A novel biphenolic compound, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane (GERI-BP002-A) was isolated from the fermentation broth ofAspergillus fumigatus F93 previously, and it has revealed cytotoxicity against human solid tumor cells. Its effective doses that cause 50% inhibition of cell growthin vitro against non-small cell lung cancer cell A549, ovarian cancer cell SK-OV-3, skin cancer cell SK-MEL-2 and central nerve system cancer cell XF498 were 8.24, 10.60, 8.83, 9.85 μg/ml respectively. GERI-BP002-A has also revealed cytotoxicity against P-glycoprotein-expressed human colon cancer cell HCT15 and its multidrug-resistant subline HCT15/CL02, and its cytotoxicity was not affected by P-glycoprotein. We have also tested cytotoxicities of structurally related compounds of GERI-BP002-A such as diphenylmethane, 1,1-bis(3,4-dimethylphenyl)ethane, 2,2-diphenylpropane, 2-benzylpyridine, 3-benzylpyridine, 4,4′-di-tert-butylphenyl, bibenzyl, 2,2′-dimethylbibenzyl,cis-stilbene,trans-stilbene, 3-tert-butyl-4-hydroxy-5-methylphenylsulfide, sulfadiazine and sulfisomidine for studying of structure and activity relationship, and from these data we could suppose that hydroxyl group of GERI-BP002-A conducted important role in its cytotoxicity. More... »

PAGES

286

References to SciGraph publications

  • 1995-04. Hydrolysable tannins and related compound having cytotoxic activity from the fruits ofTerminalia chebula in ARCHIVES OF PHARMACAL RESEARCH
  • 1996-02. Cytotoxicity of trichothecenes to human solid tumor cellsin vitro in ARCHIVES OF PHARMACAL RESEARCH
  • 1992-12. Antitumor activity ofPsoralea corylifolia in ARCHIVES OF PHARMACAL RESEARCH
  • 1994-02. Antitumor activity of some phenolic components in plants in ARCHIVES OF PHARMACAL RESEARCH
  • 1978-06. New natural products of interest under development at the National Cancer Institute in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1992-09. P-glycoprotein expression in brain tumors in JOURNAL OF NEURO-ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02976242

    DOI

    http://dx.doi.org/10.1007/bf02976242

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028972534


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Korea Research Institute of Chemical Technology", 
              "id": "https://www.grid.ac/institutes/grid.29869.3c", 
              "name": [
                "Pharmaceutical Screening Team, Korea Research Institute of Chemical Technology, Daedeog-Danji, Yusung, P.O. Box 107, 305-606, Taejeon, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choi", 
            "givenName": "Sang Un", 
            "id": "sg:person.01011104111.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011104111.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Korea Research Institute of Chemical Technology", 
              "id": "https://www.grid.ac/institutes/grid.29869.3c", 
              "name": [
                "Pharmaceutical Screening Team, Korea Research Institute of Chemical Technology, Daedeog-Danji, Yusung, P.O. Box 107, 305-606, Taejeon, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Kwang Hee", 
            "id": "sg:person.01152525264.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152525264.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Korea Research Institute of Chemical Technology", 
              "id": "https://www.grid.ac/institutes/grid.29869.3c", 
              "name": [
                "Pharmaceutical Screening Team, Korea Research Institute of Chemical Technology, Daedeog-Danji, Yusung, P.O. Box 107, 305-606, Taejeon, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Nam Young", 
            "id": "sg:person.016534206011.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016534206011.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Korea Research Institute of Chemical Technology", 
              "id": "https://www.grid.ac/institutes/grid.29869.3c", 
              "name": [
                "Pharmaceutical Screening Team, Korea Research Institute of Chemical Technology, Daedeog-Danji, Yusung, P.O. Box 107, 305-606, Taejeon, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choi", 
            "givenName": "Eun Jung", 
            "id": "sg:person.010626515211.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010626515211.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Korea Research Institute of Chemical Technology", 
              "id": "https://www.grid.ac/institutes/grid.29869.3c", 
              "name": [
                "Pharmaceutical Screening Team, Korea Research Institute of Chemical Technology, Daedeog-Danji, Yusung, P.O. Box 107, 305-606, Taejeon, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Chong Ock", 
            "id": "sg:person.01206344566.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206344566.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Bioproducts Research Group, Korea Research Institute of Bioscience & Technology, KIST, Yusung, P.O. Box 115, 305-600, Taejeon, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Son", 
            "givenName": "Kwang Hee", 
            "id": "sg:person.01301404425.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301404425.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Bioproducts Research Group, Korea Research Institute of Bioscience & Technology, KIST, Yusung, P.O. Box 115, 305-600, Taejeon, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Sung Uk", 
            "id": "sg:person.01367657322.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367657322.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Bioproducts Research Group, Korea Research Institute of Bioscience & Technology, KIST, Yusung, P.O. Box 115, 305-600, Taejeon, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bok", 
            "givenName": "Song Hae", 
            "id": "sg:person.01047235257.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047235257.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Bioproducts Research Group, Korea Research Institute of Bioscience & Technology, KIST, Yusung, P.O. Box 115, 305-600, Taejeon, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Young Kook", 
            "id": "sg:person.01303266233.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303266233.12"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0165-1218(91)90125-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000193041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-1218(91)90125-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000193041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02979144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005304550", 
              "https://doi.org/10.1007/bf02979144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02979144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005304550", 
              "https://doi.org/10.1007/bf02979144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910490511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006089776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s8755-9668(86)80030-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006676923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0277-5379(98)90039-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007424627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02976812", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012531809", 
              "https://doi.org/10.1007/bf02976812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02976812", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012531809", 
              "https://doi.org/10.1007/bf02976812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(93)90004-g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022840072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(93)90004-g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022840072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.84.1.265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026888068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02974112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033927245", 
              "https://doi.org/10.1007/bf02974112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02974112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033927245", 
              "https://doi.org/10.1007/bf02974112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00170943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034998526", 
              "https://doi.org/10.1007/bf00170943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00170943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034998526", 
              "https://doi.org/10.1007/bf00170943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910490512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035398241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bi.58.070189.001033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039747073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0009-2797(91)90029-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044764532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0009-2797(91)90029-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044764532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00254042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047077877", 
              "https://doi.org/10.1007/bf00254042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00254042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047077877", 
              "https://doi.org/10.1007/bf00254042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02978247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048701918", 
              "https://doi.org/10.1007/bf02978247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02978247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048701918", 
              "https://doi.org/10.1007/bf02978247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.1993.tb02822.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049921966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.1993.tb02822.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049921966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/81.2.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059815391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/82.13.1107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059815881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/86.9.700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059819236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.6137059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062634856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7164/antibiotics.49.31", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073635387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077260515", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077340248", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078913487", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078927514", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079049795", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/52.4.1101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080620056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082123611", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.1994.267.5.c1351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082399064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082668284", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1996-08", 
        "datePublishedReg": "1996-08-01", 
        "description": "Phenolic compounds are prevalent as toxins or environmental pollutants, but they are also widely used as drugs for various purpose including anticancer agent. A novel biphenolic compound, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane (GERI-BP002-A) was isolated from the fermentation broth ofAspergillus fumigatus F93 previously, and it has revealed cytotoxicity against human solid tumor cells. Its effective doses that cause 50% inhibition of cell growthin vitro against non-small cell lung cancer cell A549, ovarian cancer cell SK-OV-3, skin cancer cell SK-MEL-2 and central nerve system cancer cell XF498 were 8.24, 10.60, 8.83, 9.85 \u03bcg/ml respectively. GERI-BP002-A has also revealed cytotoxicity against P-glycoprotein-expressed human colon cancer cell HCT15 and its multidrug-resistant subline HCT15/CL02, and its cytotoxicity was not affected by P-glycoprotein. We have also tested cytotoxicities of structurally related compounds of GERI-BP002-A such as diphenylmethane, 1,1-bis(3,4-dimethylphenyl)ethane, 2,2-diphenylpropane, 2-benzylpyridine, 3-benzylpyridine, 4,4\u2032-di-tert-butylphenyl, bibenzyl, 2,2\u2032-dimethylbibenzyl,cis-stilbene,trans-stilbene, 3-tert-butyl-4-hydroxy-5-methylphenylsulfide, sulfadiazine and sulfisomidine for studying of structure and activity relationship, and from these data we could suppose that hydroxyl group of GERI-BP002-A conducted important role in its cytotoxicity.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/bf02976242", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1090680", 
            "issn": [
              "0253-6269", 
              "1976-3786"
            ], 
            "name": "Archives of Pharmacal Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "name": "Cytotoxicity of a novel biphenolic compound, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane against human tumor cellsin vitro", 
        "pagination": "286", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "8a04e31a5b10f734ce8e1909bbe152ddfaa77da96cb3474d434bf3dcb97596fe"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf02976242"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1028972534"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf02976242", 
          "https://app.dimensions.ai/details/publication/pub.1028972534"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T14:27", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13073_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2FBF02976242"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02976242'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02976242'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02976242'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02976242'


     

    This table displays all metadata directly associated to this object as RDF triples.

    214 TRIPLES      21 PREDICATES      57 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf02976242 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N55992322d22447ec9e79579d1bb02d8a
    4 schema:citation sg:pub.10.1007/bf00170943
    5 sg:pub.10.1007/bf00254042
    6 sg:pub.10.1007/bf02974112
    7 sg:pub.10.1007/bf02976812
    8 sg:pub.10.1007/bf02978247
    9 sg:pub.10.1007/bf02979144
    10 https://app.dimensions.ai/details/publication/pub.1077260515
    11 https://app.dimensions.ai/details/publication/pub.1077340248
    12 https://app.dimensions.ai/details/publication/pub.1078913487
    13 https://app.dimensions.ai/details/publication/pub.1078927514
    14 https://app.dimensions.ai/details/publication/pub.1079049795
    15 https://app.dimensions.ai/details/publication/pub.1082123611
    16 https://app.dimensions.ai/details/publication/pub.1082668284
    17 https://doi.org/10.1002/ijc.2910490511
    18 https://doi.org/10.1002/ijc.2910490512
    19 https://doi.org/10.1016/0006-2952(93)90004-g
    20 https://doi.org/10.1016/0009-2797(91)90029-7
    21 https://doi.org/10.1016/0165-1218(91)90125-6
    22 https://doi.org/10.1016/s0277-5379(98)90039-6
    23 https://doi.org/10.1016/s8755-9668(86)80030-8
    24 https://doi.org/10.1073/pnas.84.1.265
    25 https://doi.org/10.1093/jnci/52.4.1101
    26 https://doi.org/10.1093/jnci/81.2.116
    27 https://doi.org/10.1093/jnci/82.13.1107
    28 https://doi.org/10.1093/jnci/86.9.700
    29 https://doi.org/10.1111/j.1349-7006.1993.tb02822.x
    30 https://doi.org/10.1126/science.6137059
    31 https://doi.org/10.1146/annurev.bi.58.070189.001033
    32 https://doi.org/10.1152/ajpcell.1994.267.5.c1351
    33 https://doi.org/10.7164/antibiotics.49.31
    34 schema:datePublished 1996-08
    35 schema:datePublishedReg 1996-08-01
    36 schema:description Phenolic compounds are prevalent as toxins or environmental pollutants, but they are also widely used as drugs for various purpose including anticancer agent. A novel biphenolic compound, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane (GERI-BP002-A) was isolated from the fermentation broth ofAspergillus fumigatus F93 previously, and it has revealed cytotoxicity against human solid tumor cells. Its effective doses that cause 50% inhibition of cell growthin vitro against non-small cell lung cancer cell A549, ovarian cancer cell SK-OV-3, skin cancer cell SK-MEL-2 and central nerve system cancer cell XF498 were 8.24, 10.60, 8.83, 9.85 μg/ml respectively. GERI-BP002-A has also revealed cytotoxicity against P-glycoprotein-expressed human colon cancer cell HCT15 and its multidrug-resistant subline HCT15/CL02, and its cytotoxicity was not affected by P-glycoprotein. We have also tested cytotoxicities of structurally related compounds of GERI-BP002-A such as diphenylmethane, 1,1-bis(3,4-dimethylphenyl)ethane, 2,2-diphenylpropane, 2-benzylpyridine, 3-benzylpyridine, 4,4′-di-tert-butylphenyl, bibenzyl, 2,2′-dimethylbibenzyl,cis-stilbene,trans-stilbene, 3-tert-butyl-4-hydroxy-5-methylphenylsulfide, sulfadiazine and sulfisomidine for studying of structure and activity relationship, and from these data we could suppose that hydroxyl group of GERI-BP002-A conducted important role in its cytotoxicity.
    37 schema:genre research_article
    38 schema:inLanguage en
    39 schema:isAccessibleForFree false
    40 schema:isPartOf Naececb178a2c4e8eb9ca829eeef654e0
    41 Nd450577c7fe249dbb974423417d9d9eb
    42 sg:journal.1090680
    43 schema:name Cytotoxicity of a novel biphenolic compound, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane against human tumor cellsin vitro
    44 schema:pagination 286
    45 schema:productId Nc804924020934bfe9ae1b1684e634517
    46 Nd9ceb820f20042b28d3d995d5ed15869
    47 Ne685a16248bc4931a0ee42fe31014e6d
    48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028972534
    49 https://doi.org/10.1007/bf02976242
    50 schema:sdDatePublished 2019-04-11T14:27
    51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    52 schema:sdPublisher Ne3a528cc324f46349afbfec1016552e0
    53 schema:url http://link.springer.com/10.1007%2FBF02976242
    54 sgo:license sg:explorer/license/
    55 sgo:sdDataset articles
    56 rdf:type schema:ScholarlyArticle
    57 N0b353bcb7d33450da5471b84b310fcea rdf:first sg:person.01152525264.31
    58 rdf:rest Nd84be13206ab46d394826a3c21fd6225
    59 N327cd735bb9241faa0fde2711cbe8223 schema:name Bioproducts Research Group, Korea Research Institute of Bioscience & Technology, KIST, Yusung, P.O. Box 115, 305-600, Taejeon, Korea
    60 rdf:type schema:Organization
    61 N3880193a6ff743f0bcee71052a4c01eb rdf:first sg:person.01206344566.61
    62 rdf:rest Nbcbb9b2a915a42849e70dc95fc6bc0e4
    63 N3e520dc7a09649a98b0d065d23ae2f79 schema:name Bioproducts Research Group, Korea Research Institute of Bioscience & Technology, KIST, Yusung, P.O. Box 115, 305-600, Taejeon, Korea
    64 rdf:type schema:Organization
    65 N4d6d64839f9e493892c69ab37a466ee8 schema:name Bioproducts Research Group, Korea Research Institute of Bioscience & Technology, KIST, Yusung, P.O. Box 115, 305-600, Taejeon, Korea
    66 rdf:type schema:Organization
    67 N55992322d22447ec9e79579d1bb02d8a rdf:first sg:person.01011104111.66
    68 rdf:rest N0b353bcb7d33450da5471b84b310fcea
    69 N696a7d948d90493ba5406e9448c45636 rdf:first sg:person.010626515211.34
    70 rdf:rest N3880193a6ff743f0bcee71052a4c01eb
    71 N8e74d99874484ef4bab080aca5e03496 schema:name Bioproducts Research Group, Korea Research Institute of Bioscience & Technology, KIST, Yusung, P.O. Box 115, 305-600, Taejeon, Korea
    72 rdf:type schema:Organization
    73 Na3b7e90c43094952ac18b574f1d3dab7 rdf:first sg:person.01367657322.13
    74 rdf:rest Nba0948e3626945568f37307a915251a0
    75 Naececb178a2c4e8eb9ca829eeef654e0 schema:volumeNumber 19
    76 rdf:type schema:PublicationVolume
    77 Nba0948e3626945568f37307a915251a0 rdf:first sg:person.01047235257.15
    78 rdf:rest Ne0ef24627ed14cb3a08d9b9ef0e5f0cd
    79 Nbcbb9b2a915a42849e70dc95fc6bc0e4 rdf:first sg:person.01301404425.18
    80 rdf:rest Na3b7e90c43094952ac18b574f1d3dab7
    81 Nc804924020934bfe9ae1b1684e634517 schema:name dimensions_id
    82 schema:value pub.1028972534
    83 rdf:type schema:PropertyValue
    84 Nd450577c7fe249dbb974423417d9d9eb schema:issueNumber 4
    85 rdf:type schema:PublicationIssue
    86 Nd84be13206ab46d394826a3c21fd6225 rdf:first sg:person.016534206011.50
    87 rdf:rest N696a7d948d90493ba5406e9448c45636
    88 Nd9ceb820f20042b28d3d995d5ed15869 schema:name readcube_id
    89 schema:value 8a04e31a5b10f734ce8e1909bbe152ddfaa77da96cb3474d434bf3dcb97596fe
    90 rdf:type schema:PropertyValue
    91 Ne0ef24627ed14cb3a08d9b9ef0e5f0cd rdf:first sg:person.01303266233.12
    92 rdf:rest rdf:nil
    93 Ne3a528cc324f46349afbfec1016552e0 schema:name Springer Nature - SN SciGraph project
    94 rdf:type schema:Organization
    95 Ne685a16248bc4931a0ee42fe31014e6d schema:name doi
    96 schema:value 10.1007/bf02976242
    97 rdf:type schema:PropertyValue
    98 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    99 schema:name Medical and Health Sciences
    100 rdf:type schema:DefinedTerm
    101 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    102 schema:name Oncology and Carcinogenesis
    103 rdf:type schema:DefinedTerm
    104 sg:journal.1090680 schema:issn 0253-6269
    105 1976-3786
    106 schema:name Archives of Pharmacal Research
    107 rdf:type schema:Periodical
    108 sg:person.01011104111.66 schema:affiliation https://www.grid.ac/institutes/grid.29869.3c
    109 schema:familyName Choi
    110 schema:givenName Sang Un
    111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011104111.66
    112 rdf:type schema:Person
    113 sg:person.01047235257.15 schema:affiliation N4d6d64839f9e493892c69ab37a466ee8
    114 schema:familyName Bok
    115 schema:givenName Song Hae
    116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047235257.15
    117 rdf:type schema:Person
    118 sg:person.010626515211.34 schema:affiliation https://www.grid.ac/institutes/grid.29869.3c
    119 schema:familyName Choi
    120 schema:givenName Eun Jung
    121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010626515211.34
    122 rdf:type schema:Person
    123 sg:person.01152525264.31 schema:affiliation https://www.grid.ac/institutes/grid.29869.3c
    124 schema:familyName Kim
    125 schema:givenName Kwang Hee
    126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152525264.31
    127 rdf:type schema:Person
    128 sg:person.01206344566.61 schema:affiliation https://www.grid.ac/institutes/grid.29869.3c
    129 schema:familyName Lee
    130 schema:givenName Chong Ock
    131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206344566.61
    132 rdf:type schema:Person
    133 sg:person.01301404425.18 schema:affiliation N3e520dc7a09649a98b0d065d23ae2f79
    134 schema:familyName Son
    135 schema:givenName Kwang Hee
    136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301404425.18
    137 rdf:type schema:Person
    138 sg:person.01303266233.12 schema:affiliation N327cd735bb9241faa0fde2711cbe8223
    139 schema:familyName Kim
    140 schema:givenName Young Kook
    141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303266233.12
    142 rdf:type schema:Person
    143 sg:person.01367657322.13 schema:affiliation N8e74d99874484ef4bab080aca5e03496
    144 schema:familyName Kim
    145 schema:givenName Sung Uk
    146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367657322.13
    147 rdf:type schema:Person
    148 sg:person.016534206011.50 schema:affiliation https://www.grid.ac/institutes/grid.29869.3c
    149 schema:familyName Kim
    150 schema:givenName Nam Young
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016534206011.50
    152 rdf:type schema:Person
    153 sg:pub.10.1007/bf00170943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034998526
    154 https://doi.org/10.1007/bf00170943
    155 rdf:type schema:CreativeWork
    156 sg:pub.10.1007/bf00254042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047077877
    157 https://doi.org/10.1007/bf00254042
    158 rdf:type schema:CreativeWork
    159 sg:pub.10.1007/bf02974112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033927245
    160 https://doi.org/10.1007/bf02974112
    161 rdf:type schema:CreativeWork
    162 sg:pub.10.1007/bf02976812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012531809
    163 https://doi.org/10.1007/bf02976812
    164 rdf:type schema:CreativeWork
    165 sg:pub.10.1007/bf02978247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048701918
    166 https://doi.org/10.1007/bf02978247
    167 rdf:type schema:CreativeWork
    168 sg:pub.10.1007/bf02979144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005304550
    169 https://doi.org/10.1007/bf02979144
    170 rdf:type schema:CreativeWork
    171 https://app.dimensions.ai/details/publication/pub.1077260515 schema:CreativeWork
    172 https://app.dimensions.ai/details/publication/pub.1077340248 schema:CreativeWork
    173 https://app.dimensions.ai/details/publication/pub.1078913487 schema:CreativeWork
    174 https://app.dimensions.ai/details/publication/pub.1078927514 schema:CreativeWork
    175 https://app.dimensions.ai/details/publication/pub.1079049795 schema:CreativeWork
    176 https://app.dimensions.ai/details/publication/pub.1082123611 schema:CreativeWork
    177 https://app.dimensions.ai/details/publication/pub.1082668284 schema:CreativeWork
    178 https://doi.org/10.1002/ijc.2910490511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006089776
    179 rdf:type schema:CreativeWork
    180 https://doi.org/10.1002/ijc.2910490512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035398241
    181 rdf:type schema:CreativeWork
    182 https://doi.org/10.1016/0006-2952(93)90004-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1022840072
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1016/0009-2797(91)90029-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044764532
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1016/0165-1218(91)90125-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000193041
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1016/s0277-5379(98)90039-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007424627
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1016/s8755-9668(86)80030-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006676923
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1073/pnas.84.1.265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026888068
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1093/jnci/52.4.1101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080620056
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1093/jnci/81.2.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059815391
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1093/jnci/82.13.1107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059815881
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1093/jnci/86.9.700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059819236
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1111/j.1349-7006.1993.tb02822.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049921966
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1126/science.6137059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062634856
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1146/annurev.bi.58.070189.001033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039747073
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1152/ajpcell.1994.267.5.c1351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082399064
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.7164/antibiotics.49.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073635387
    211 rdf:type schema:CreativeWork
    212 https://www.grid.ac/institutes/grid.29869.3c schema:alternateName Korea Research Institute of Chemical Technology
    213 schema:name Pharmaceutical Screening Team, Korea Research Institute of Chemical Technology, Daedeog-Danji, Yusung, P.O. Box 107, 305-606, Taejeon, Korea
    214 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...