Intestinal bacterial β-glucuronidase activity of patients with colon cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-12

AUTHORS

Dong-Hyun Kim, Young-Ho Jin

ABSTRACT

The fecal β-glucuronidase activity of patients with colon cancer and healthy controls were measured to determine the relationship between the fluctuation of intestinal bacterial β-glucuronidase and colon cancer. The fecal β-glucuronidase activity of patients with colon cancer was 1.7 times higher than that of the healthy controls. However, when these fecal specimens were sonicated, the enzyme activity of patients with colon cancer was 12.1 times higher than that of the healthy controls. The fecal β-glucuronidase activity of human intestinal bacteria was drastically induced by its substrate or the bile secreted after a subcutaneous injection of 1,2-dimethylhydrazine (DMH) and benzo[a]pyrene into rats. DMH-and benzo[a]pyrene-treated biles induced β-glucuronidase activity in the human intestinal microflora by approximately 1.5- and 2.3-fold, respectively. They also induced β-glucuronidase inE. coli HGU-3, which is a β-glucuronidase-producing bacterium from the human intestine. D-saccharic acid 1,4-lactone similarly inhibited fecal β-glucuronidase in several patients with colon cancer in addition to the healthy controls. This suggests that potent β-glucuronidase activity is a prime factor in the etiology of colon cancer. More... »

PAGES

564

References to SciGraph publications

  • 1995-04. Protective roles of mushrooms in experimental colon carcinogenesis in ARCHIVES OF PHARMACAL RESEARCH
  • Journal

    TITLE

    Archives of Pharmacal Research

    ISSUE

    6

    VOLUME

    24

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02975166

    DOI

    http://dx.doi.org/10.1007/bf02975166

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041341388

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11794536


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